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SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration.
Figley MD, Gu W, Nanson JD, Shi Y, Sasaki Y, Cunnea K, Malde AK, Jia X, Luo Z, Saikot FK, Mosaiab T, Masic V, Holt S, Hartley-Tassell L, McGuinness HY, Manik MK, Bosanac T, Landsberg MJ, Kerry PS, Mobli M, Hughes RO, Milbrandt J, Kobe B, DiAntonio A, Ve T. Figley MD, et al. Neuron. 2021 Apr 7;109(7):1118-1136.e11. doi: 10.1016/j.neuron.2021.02.009. Epub 2021 Mar 2. Neuron. 2021. PMID: 33657413 Free PMC article.
Dravet Syndrome: A Developmental and Epileptic Encephalopathy.
Lopez-Santiago L, Isom LL. Lopez-Santiago L, et al. Epilepsy Curr. 2019 Jan;19(1):51-53. doi: 10.1177/1535759718822038. Epub 2019 Jan 30. Epilepsy Curr. 2019. PMID: 30838929 Free PMC article.
Selective Nav1.1 Activation Rescues Dravet Syndrome Mice From Seizures and Premature Death Richards KL, Milligan CJ, Richardson RJ, Jancovski N, Grunnet M, Jacobson LH, Undheim EAB, Mobli M, Chow CY, Herzig V, Csoti A, Panyi G, Reid CA, King GF, Petrou S. ... …
Selective Nav1.1 Activation Rescues Dravet Syndrome Mice From Seizures and Premature Death Richards KL, Milligan CJ, Richardson RJ, Jancovsk …
Suppressive effects of increasing mungbean density on growth and reproduction of junglerice and feather fingergrass.
Matloob A, Mobli A, Chauhan BS. Matloob A, et al. Sci Rep. 2023 Apr 3;13(1):5451. doi: 10.1038/s41598-023-32320-1. Sci Rep. 2023. PMID: 37012305 Free PMC article.
Wilczek] densities (0, 82, 164, 242, and 328 plants m(-2)). A target-neighbourhood study was conducted using a completely randomized design with five replications, and there were two experimental runs in 2016-2017. ...An increase in mungbean density from 82 to 328 plants …
Wilczek] densities (0, 82, 164, 242, and 328 plants m(-2)). A target-neighbourhood study was conducted using a completely randomized …
Solution structure and peptide binding of the PTB domain from the AIDA1 postsynaptic signaling scaffolding protein.
Smirnova E, Shanbhag R, Kurabi A, Mobli M, Kwan JJ, Donaldson LW. Smirnova E, et al. PLoS One. 2013 Jun 14;8(6):e65605. doi: 10.1371/journal.pone.0065605. Print 2013. PLoS One. 2013. PMID: 23799029 Free PMC article.
Using peptide arrays and fluorescence based assays, we determined that the AIDA1 PTB domain binds amyloid protein precursor (APP) in a similar manner to the X11/Mint PTB domain, albeit at reduced affinity (10 M) that may allow AIDA1 to effectively sample APP, as well as ot …
Using peptide arrays and fluorescence based assays, we determined that the AIDA1 PTB domain binds amyloid protein precursor (APP) in a simil …
An NMR, IR and theoretical investigation of (1)H chemical shifts and hydrogen bonding in phenols.
Abraham RJ, Mobli M. Abraham RJ, et al. Magn Reson Chem. 2007 Oct;45(10):865-77. doi: 10.1002/mrc.2060. Magn Reson Chem. 2007. PMID: 17729232
The plots were all linear with concentration, the gradients varying from 0.940 (phenol) to 7.85 (4-cyanophenol) ppm/M because of competing inter- and intramolecular hydrogen bonding. Ab initio calculations of a model acetone/phenol system showed that the OH shielding was l …
The plots were all linear with concentration, the gradients varying from 0.940 (phenol) to 7.85 (4-cyanophenol) ppm/M because of comp …
Rational Engineering Defines a Molecular Switch That Is Essential for Activity of Spider-Venom Peptides against the Analgesics Target NaV1.7.
Klint JK, Chin YK, Mobli M. Klint JK, et al. Mol Pharmacol. 2015 Dec;88(6):1002-10. doi: 10.1124/mol.115.100784. Epub 2015 Oct 1. Mol Pharmacol. 2015. PMID: 26429937
However, one member of this family [-TRTX-Hhn2b (Hhn2b)] does not inhibit mammalian NaV channels expressed in dorsal root ganglia at concentrations up to 100 M. This peptide is classified as a NaSpTx1 member by virtue of its cysteine spacing and sequence conservation over …
However, one member of this family [-TRTX-Hhn2b (Hhn2b)] does not inhibit mammalian NaV channels expressed in dorsal root ganglia at concent …
Three-dimensional 13C-detected CH3-TOCSY using selectively protonated proteins: facile methyl resonance assignment and protein structure determination.
Jordan JB, Kovacs H, Wang Y, Mobli M, Luo R, Anklin C, Hoch JC, Kriwacki RW. Jordan JB, et al. J Am Chem Soc. 2006 Jul 19;128(28):9119-28. doi: 10.1021/ja058587a. J Am Chem Soc. 2006. PMID: 16834385
Selective methyl protonation, originally developed by Kay and co-workers (Rosen, M. K.; Gardner, K. H.; Willis, R. C.; Parris, W. E.; Pawson, T.; Kay, L. E. J. Mol. ...
Selective methyl protonation, originally developed by Kay and co-workers (Rosen, M. K.; Gardner, K. H.; Willis, R. C.; Parris, W. E.; …
1H chemical shifts in NMR. Part 20--anisotropic and steric effects in halogen substituent chemical shifts (SCS), a modelling and ab initio investigation.
Abraham RJ, Mobli M, Smith RJ. Abraham RJ, et al. Magn Reson Chem. 2004 May;42(5):436-44. doi: 10.1002/mrc.1369. Magn Reson Chem. 2004. PMID: 15095379
These different prediction methods were compared by pie charts, scatter plots and r.m.s. errors and the CHARGE program was shown to be more accurate for the compounds considered here than the other two methods. ...
These different prediction methods were compared by pie charts, scatter plots and r.m.s. errors and the CHARGE program was shown to b …
1H chemical shifts in NMR. Part 21--prediction of the 1H chemical shifts of molecules containing the ester group: a modelling and ab initio investigation.
Abraham RJ, Bardsley B, Mobli M, Smith RJ. Abraham RJ, et al. Magn Reson Chem. 2005 Jan;43(1):3-15. doi: 10.1002/mrc.1491. Magn Reson Chem. 2005. PMID: 15390026
For the 24 compounds investigated with 150 1H chemical shifts spanning a range of ca 10 ppm, the CHARGE model gave an excellent r.m.s. error (obs - calc) of <0.1 ppm. The GIAO calculations gave a very reasonable r.m.s. error of ca 0.2 ppm although larger deviatio …
For the 24 compounds investigated with 150 1H chemical shifts spanning a range of ca 10 ppm, the CHARGE model gave an excellent r.m.s …