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Empagliflozin in Patients with Chronic Kidney Disease.
The EMPA-KIDNEY Collaborative Group; Herrington WG, Staplin N, Wanner C, Green JB, Hauske SJ, Emberson JR, Preiss D, Judge P, Mayne KJ, Ng SYA, Sammons E, Zhu D, Hill M, Stevens W, Wallendszus K, Brenner S, Cheung AK, Liu ZH, Li J, Hooi LS, Liu W, Kadowaki T, Nangaku M, Levin A, Cherney D, Maggioni AP, Pontremoli R, Deo R, Goto S, Rossello X, Tuttle KR, Steubl D, Petrini M, Massey D, Eilbracht J, Brueckmann M, Landray MJ, Baigent C, Haynes R. The EMPA-KIDNEY Collaborative Group, et al. N Engl J Med. 2023 Jan 12;388(2):117-127. doi: 10.1056/NEJMoa2204233. Epub 2022 Nov 4. N Engl J Med. 2023. PMID: 36331190 Free PMC article. Clinical Trial.
METHODS: We enrolled patients with chronic kidney disease who had an estimated glomerular filtration rate (eGFR) of at least 20 but less than 45 ml per minute per 1.73 m(2) of body-surface area, or who had an eGFR of at least 45 but less than 90 ml per minute per 1.73 m
METHODS: We enrolled patients with chronic kidney disease who had an estimated glomerular filtration rate (eGFR) of at least 20 but less tha …
Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.
Salloway S, Sperling R, Fox NC, Blennow K, Klunk W, Raskind M, Sabbagh M, Honig LS, Porsteinsson AP, Ferris S, Reichert M, Ketter N, Nejadnik B, Guenzler V, Miloslavsky M, Wang D, Lu Y, Lull J, Tudor IC, Liu E, Grundman M, Yuen E, Black R, Brashear HR; Bapineuzumab 301 and 302 Clinical Trial Investigators. Salloway S, et al. N Engl J Med. 2014 Jan 23;370(4):322-33. doi: 10.1056/NEJMoa1304839. N Engl J Med. 2014. PMID: 24450891 Free PMC article. Clinical Trial.
Polymer-based or Polymer-free Stents in Patients at High Bleeding Risk.
Windecker S, Latib A, Kedhi E, Kirtane AJ, Kandzari DE, Mehran R, Price MJ, Abizaid A, Simon DI, Worthley SG, Zaman A, Hudec M, Poliacikova P, Abdul Ghapar AKB, Selvaraj K, Petrov I, Mylotte D, Pinar E, Moreno R, Fabbiocchi F, Pasupati S, Kim HS, Aminian A, Tie C, Wlodarczak A, Hur SH, Marx SO, Jankovic I, Brar S, Bousquette L, Liu M, Stone GW; ONYX ONE Investigators. Windecker S, et al. N Engl J Med. 2020 Mar 26;382(13):1208-1218. doi: 10.1056/NEJMoa1910021. Epub 2020 Feb 12. N Engl J Med. 2020. PMID: 32050061 Free article. Clinical Trial.
Prospective Multicenter Randomized All-Comers Trial to Assess the Safety and Effectiveness of the Ultra-Thin Strut Sirolimus-Eluting Coronary Stent Supraflex: Two-Year Outcomes of the TALENT Trial.
Gao C, Kogame N, Sharif F, Smits PC, Tonino P, Hofma S, Moreno R, Choudhury A, Petrov I, Cequier A, Colombo A, Kaul U, Zaman A, de Winter RJ, Onuma Y, Serruys PW. Gao C, et al. Circ Cardiovasc Interv. 2021 Mar;14(3):e010312. doi: 10.1161/CIRCINTERVENTIONS.120.010312. Epub 2021 Mar 9. Circ Cardiovasc Interv. 2021. PMID: 33685213 No abstract available.
Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women.
Baeten JM, Palanee-Phillips T, Brown ER, Schwartz K, Soto-Torres LE, Govender V, Mgodi NM, Matovu Kiweewa F, Nair G, Mhlanga F, Siva S, Bekker LG, Jeenarain N, Gaffoor Z, Martinson F, Makanani B, Pather A, Naidoo L, Husnik M, Richardson BA, Parikh UM, Mellors JW, Marzinke MA, Hendrix CW, van der Straten A, Ramjee G, Chirenje ZM, Nakabiito C, Taha TE, Jones J, Mayo A, Scheckter R, Berthiaume J, Livant E, Jacobson C, Ndase P, White R, Patterson K, Germuga D, Galaska B, Bunge K, Singh D, Szydlo DW, Montgomery ET, Mensch BS, Torjesen K, Grossman CI, Chakhtoura N, Nel A, Rosenberg Z, McGowan I, Hillier S; MTN-020–ASPIRE Study Team. Baeten JM, et al. N Engl J Med. 2016 Dec 1;375(22):2121-2132. doi: 10.1056/NEJMoa1506110. Epub 2016 Feb 22. N Engl J Med. 2016. PMID: 26900902 Free PMC article. Clinical Trial.
Prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors.
Patel A, Göbel K, Ille S, Hinz F, Schoebe N, Bogumil H, Meyer J, Brehm M, Kardo H, Schrimpf D, Lomakin A, Ritter M, Göller P, Kerbs P, Pfeifer L, Hamelmann S, Blume C, Ippen FM, Berghaus N, Euskirchen P, Schweizer L, Hultschig C, Van Roy N, Van Dorpe J, Van der Meulen J, Loontiens S, Dedeurwaerdere F, Leske H, Halldórsson S, Fox G, Deacon S, Cahyani I, Holmes N, Wibowo S, Munro R, Martin D, Sharif A, Housley M, Goldspring R, Brandner S, Roy S, Hench J, Frank S, Unterberg A, Goidts V, Jäger N, Paine S, Smith S, Herold-Mende C, Wick W, Pfister SM, Vik-Mo EO, von Deimling A, Krieg S, Jones DT, Loose M, Schlesner M, Sill M, Sahm F. Patel A, et al. Nat Med. 2025 Mar 25. doi: 10.1038/s41591-025-03562-5. Online ahead of print. Nat Med. 2025. PMID: 40133526
Sulfhydryl groups in receptor binding of thyrotropin-releasing hormone to rat amygdala.
Sharif NA, Burt DR. Sharif NA, et al. J Neurochem. 1984 Jan;42(1):209-14. doi: 10.1111/j.1471-4159.1984.tb09719.x. J Neurochem. 1984. PMID: 6315888
Heavy metals (Cd2+, Hg2+), which complex with reactive -SH residues, also potently inhibited binding. The pharmacological specificity of residual [3H]MeTRH binding in chemically modified amygdala membranes was the same as that in control preparations. ...Pretreatment of me …
Heavy metals (Cd2+, Hg2+), which complex with reactive -SH residues, also potently inhibited binding. The pharmacological specificity …