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Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19.
Hammond J, Leister-Tebbe H, Gardner A, Abreu P, Bao W, Wisemandle W, Baniecki M, Hendrick VM, Damle B, Simón-Campos A, Pypstra R, Rusnak JM; EPIC-HR Investigators. Hammond J, et al. N Engl J Med. 2022 Apr 14;386(15):1397-1408. doi: 10.1056/NEJMoa2118542. Epub 2022 Feb 16. N Engl J Med. 2022. PMID: 35172054 Free PMC article. Clinical Trial.
BACKGROUND: Nirmatrelvir is an orally administered severe acute respiratory syndrome coronavirus 2 main protease (M(pro)) inhibitor with potent pan-human-coronavirus activity in vitro. METHODS: We conducted a phase 2-3 double-blind, randomized, controlled trial in which sy …
BACKGROUND: Nirmatrelvir is an orally administered severe acute respiratory syndrome coronavirus 2 main protease (M(pro)) inhibitor w …
Corrigendum to: Prevalence and incidence of type 1 diabetes in the world: a systematic review and meta-analysis Mobasseri M, Shirmohammadi M, Amiri T, Vahed N, Hosseini Fard H, Ghojazadeh M. Health Promot Perspect. 2020 Mar 30;10(2):98-115. doi: 10.34172/hpp.2020.18.
Mobasseri M, Shirmohammadi M, Amiri T, Vahed N, Hosseini Fard H, Ghojazadeh M. Mobasseri M, et al. Health Promot Perspect. 2024 Jul 29;14(2):202-205. doi: 10.34172/hpp.43143. eCollection 2024. Health Promot Perspect. 2024. PMID: 39291043 Free PMC article.
A CD38-directed, single-chain T-cell engager targets leukemia stem cells through IFN-γ-induced CD38 expression.
Murtadha M, Park M, Zhu Y, Caserta E, Napolitano O, Tandoh T, Moloudizargari M, Pozhitkov A, Singer M, Dona AA, Vahed H, Gonzalez A, Ly K, Ouyang C, Sanchez JF, Nigam L, Duplan A, Chowdhury A, Ghoda L, Li L, Zhang B, Krishnan A, Marcucci G, Williams JC, Pichiorri F. Murtadha M, et al. Blood. 2024 Apr 18;143(16):1599-1615. doi: 10.1182/blood.2023021570. Blood. 2024. PMID: 38394668 Free PMC article.
Neutralizing and binding antibodies are a correlate of risk of COVID-19 in the CoVPN 3008 study in people with HIV.
Mkhize NN, Zhang B, Brackett C, Elyanu PJ, Tapley A, Dadabhai S, Hu J, Do BTN, Schuster DJ, Heptinstall J, Sawant S, Seaton K, Sarzotti-Kelsoe M, Hudson A, Jin Y, Bhebhe S, Kaldine H, Kgagudi P, Modise T, Mgodi NM, Andriesen J, Randhawa AK, Fisher LH, Kee JJ, Magaret CA, Peng J, Kenny A, Carpp LN, Chen Z, Heng S, Villaran M, Takalani A, Le Roux B, Wilkinson E, Odhiambo J, Shah P, Polakowski L, Yacovone M, Samandari T, Chirenje Z, Makhema J, Kamuti E, Njekwa K, Nuwagaba-Biribonwoha H, Baguma A, Badal-Faesen S, Brumskine W, Coetzer S, Dawson R, Delany-Moretlwe S, Diacon AH, Fry S, Gill K, Madikida A, Hoosain ZAE, Hosseinipour MC, Inambao M, Innes C, Innes S, Kalonji D, Mwape H, Kassim P, Kamanga MC, Kilembe W, Laher F, Malahleha M, Maluleke VL, Mboya G, Madiega PA, McHarry K, Mitha E, Duki Y, Mda P, Moerane M, Moloantoa T, Nuwamanya S, Mahomed S, Naicker V, Nana A, Nanvubya A, Kawoozo B, Nchabeleng M, Otieno W, Potgieter EL, Potloane D, Punt Z, Said J, Singh Y, Kassim S, van der Vendt D, Tayob MS, Vahed Y, Wabwire DO, Kublin JG, Bekker LG, Corey L, Gray GE, Huang Y, Kotze P, Garrett N, Hural J, Ferrari G, Andersen-Nissen E, Montefiori D, Moore PL, McElrath MJ, Tomaras GD, Gilbert PB… See abstract for full author list ➔ Mkhize NN, et al. Nat Commun. 2025 Oct 6;16(1):8876. doi: 10.1038/s41467-025-63948-4. Nat Commun. 2025. PMID: 41053137 Free PMC article.
Hybrid versus vaccine immunity of mRNA-1273 among people living with HIV in East and Southern Africa: a prospective cohort analysis from the multicentre CoVPN 3008 (Ubuntu) study.
Garrett N, Tapley A, Hudson A, Dadabhai S, Zhang B, Mgodi NM, Andriesen J, Takalani A, Fisher LH, Kee JJ, Magaret CA, Villaran M, Hural J, Andersen-Nissen E, Ferarri G, Miner MD, Le Roux B, Wilkinson E, Lessells R, de Oliveira T, Odhiambo J, Shah P, Polakowski L, Yacovone M, Samandari T, Chirenje Z, Elyanu PJ, Makhema J, Kamuti E, Nuwagaba-Biribonwoha H, Badal-Faesen S, Brumskine W, Coetzer S, Dawson R, Delany-Moretlwe S, Diacon AH, Fry S, Gill KM, Ebrahim Hoosain ZA, Hosseinipour MC, Inambao M, Innes C, Innes S, Kalonji D, Kasaro M, Kassim P, Kayange N, Kilembe W, Laher F, Malahleha M, Maluleke VL, Mboya G, McHarry K, Mitha E, Mngadi K, Mda P, Moloantoa T, Mutuluuza CK, Naicker N, Naicker V, Nana A, Nanvubya A, Nchabeleng M, Otieno W, Potgieter EL, Potloane D, Punt Z, Said J, Singh Y, Tayob MS, Vahed Y, Wabwire DO, McElrath MJ, Kublin JG, Bekker LG, Gilbert PB, Corey L, Gray GE, Huang Y, Kotze P; CoVPN 3008 Ubuntu Study Team. Garrett N, et al. EClinicalMedicine. 2025 Jan 20;80:103054. doi: 10.1016/j.eclinm.2024.103054. eCollection 2025 Feb. EClinicalMedicine. 2025. PMID: 39902315 Free PMC article.
A multi-epitope/CXCL11 prime/pull coronavirus mucosal vaccine boosts the frequency and the function of lung-resident memory CD4+ and CD8+ T cells and enhanced protection against COVID-19-like symptoms and death caused by SARS-CoV-2 infection.
Zayou L, Prakash S, Dhanushkodi NR, Quadiri A, Ibraim IC, Singer M, Salem A, Shaik AM, Suzer B, Chilukuri A, Tran J, Nguyen PC, Sun M, Hormi-Carver KK, Belmouden A, Vahed H, Gil D, Ulmer JB, BenMohamed L. Zayou L, et al. J Virol. 2023 Dec 21;97(12):e0109623. doi: 10.1128/jvi.01096-23. Epub 2023 Dec 1. J Virol. 2023. PMID: 38038432 Free PMC article.
CCL113, a novel sulfonamide, induces selective mitotic arrest and apoptosis in HeLa and HepG2 cells.
Yi R, Ohno Y, Tian Z, Guo S, Chen W, Ma X, Win NN, Li Q, Vahed M, Saito K, Nakamoto S, Suganami A, Isegawa N, Yoshida K, Harada S, Tamura Y, Nishida A, Shirasawa H. Yi R, et al. Oncol Rep. 2020 Dec;44(6):2770-2782. doi: 10.3892/or.2020.7805. Epub 2020 Oct 13. Oncol Rep. 2020. PMID: 33125152
FACS analyses showed that CCL113 treatment increased the proportion of cancerous and noncancerous cells in the G2/M phase. Analyses of cell cycle regulatory proteins showed that CCL113 treatment inhibited the activity of CDK1 in HeLa cells, possibly due to the decrease in …
FACS analyses showed that CCL113 treatment increased the proportion of cancerous and noncancerous cells in the G2/M phase. Analyses o …
Efficacy and Safety of Adintrevimab (ADG20) for the Treatment of High-Risk Ambulatory Patients With Mild or Moderate Coronavirus Disease 2019: Results From a Phase 2/3, Randomized, Placebo-Controlled Trial (STAMP) Conducted During Delta Predominance and Early Emergence of Omicron.
Ison MG, Popejoy M, Evgeniev N, Tzekova M, Mahoney K, Betancourt N, Li Y, Gupta D, Narayan K, Hershberger E, Connolly LE, Yalcin I, Das AF, Genge J, Smith M, Campanaro E, Hawn P, Schmidt P; STAMP Study Group. Ison MG, et al. Open Forum Infect Dis. 2023 May 24;10(6):ofad279. doi: 10.1093/ofid/ofad279. eCollection 2023 Jun. Open Forum Infect Dis. 2023. PMID: 37351456 Free PMC article.
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