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Page 1
Structural insights into an atypical histone binding mechanism by a PHD finger.
Grégoire S, Grégoire J, Yang Y, Capitani S, Joshi M, Sarvan S, Zaker A, Ning Z, Figeys D, Ulrich K, Brunzelle JS, Mer A, Couture JF. Grégoire S, et al. Structure. 2024 Sep 5;32(9):1498-1506.e4. doi: 10.1016/j.str.2024.06.017. Epub 2024 Jul 18. Structure. 2024. PMID: 39029460 Free article.
The structure of Cfp1(PHD) in complex with H3K4me3 shows unique features such as non-canonical coordination of the first zinc atom and a disulfide bond forcing the reorientation of Cfp1(PHD) N-terminus, thereby leading to an atypical H3K4me3 binding pocket. This configurat …
The structure of Cfp1(PHD) in complex with H3K4me3 shows unique features such as non-canonical coordination of the first zinc atom and a dis …
Inhibitor in Congenital Factor VII Deficiency; a Rare but Serious Therapeutic Challenge-A Systematic Literature Review.
Ramezanpour N, Zaker F, Biswas A, Dorgalaleh A. Ramezanpour N, et al. J Clin Med. 2021 Jan 8;10(2):211. doi: 10.3390/jcm10020211. J Clin Med. 2021. PMID: 33435610 Free PMC article. Review.
All patients had severe FVII deficiency (FVII:C < 10%), and the majority received recombinant FVII prior to inhibitor development (N: 24, 89%). Among ten patients with a detected mutation, three subjects had a common non-sense (30%), and two had a deletion (20%). ...

All patients had severe FVII deficiency (FVII:C < 10%), and the majority received recombinant FVII prior to inhibitor development (N

…
Apoptosis in field and experimental cases of avian influenza H(9)N(2) infection in broiler chickens in Iran.
Zaker SR, Nili H, Asasi K. Zaker SR, et al. Vet Res Forum. 2022 Sep;13(3):439-441. doi: 10.30466/vrf.2020.119136.2818. Epub 2022 Sep 15. Vet Res Forum. 2022. PMID: 36320299 Free PMC article.
Avian influenza virus subtype H(9)N(2) is widely circulating around the globe affecting many species of animal including mammals and birds as well as human beings. ...Ultra-structural features of apoptosis in field and experimental infection of H(9)N(2) avian influe …
Avian influenza virus subtype H(9)N(2) is widely circulating around the globe affecting many species of animal including mammals and …
Prognostic impact of systemic inflammatory diseases in elderly patients with congestive heart failure.
Burkard T, Pfister O, Rickli H, Follath F, Hack D, Zaker R, Pittl U, Handschin R, Pfisterer M, Brunner-La Rocca HP; Time-CHF Investigators. Burkard T, et al. QJM. 2014 Feb;107(2):131-8. doi: 10.1093/qjmed/hct205. Epub 2013 Oct 15. QJM. 2014. PMID: 24131549 Free article.
At baseline, 38 patients had history of SID (6.1%). These patients had higher N-terminal pro brain natriuretic peptide and worse renal function than patients without SID. ...
At baseline, 38 patients had history of SID (6.1%). These patients had higher N-terminal pro brain natriuretic peptide and worse rena …
BNP-guided vs symptom-guided heart failure therapy: the Trial of Intensified vs Standard Medical Therapy in Elderly Patients With Congestive Heart Failure (TIME-CHF) randomized trial.
Pfisterer M, Buser P, Rickli H, Gutmann M, Erne P, Rickenbacher P, Vuillomenet A, Jeker U, Dubach P, Beer H, Yoon SI, Suter T, Osterhues HH, Schieber MM, Hilti P, Schindler R, Brunner-La Rocca HP; TIME-CHF Investigators. Pfisterer M, et al. JAMA. 2009 Jan 28;301(4):383-92. doi: 10.1001/jama.2009.2. JAMA. 2009. PMID: 19176440 Clinical Trial.
CONTEXT: It is uncertain whether intensified heart failure therapy guided by N-terminal brain natriuretic peptide (BNP) is superior to symptom-guided therapy. OBJECTIVE: To compare 18-month outcomes of N-terminal BNP-guided vs symptom-guided heart failure therapy. . …
CONTEXT: It is uncertain whether intensified heart failure therapy guided by N-terminal brain natriuretic peptide (BNP) is superior t …
Molecular and clinical profile of congenital fibrinogen disorders in Iran, identification of two novel mutations.
Tavasoli B, Safa M, Dorgalaleh A, Ghasemi JB, Rezaei Makhouri F, Rezvani MR, Ahmadi A, Tabibian S, Jazebi M, Baghaipour MR, Zaker F. Tavasoli B, et al. Int J Lab Hematol. 2020 Oct;42(5):619-627. doi: 10.1111/ijlh.13258. Epub 2020 Jul 8. Int J Lab Hematol. 2020. PMID: 32639687
Umbilical cord bleeding was the most common clinical presentation (n: 9, ~70%) which led to the diagnosis of afibrinogenemia, while menorrhagia led to the diagnosis of dysfibrinogenemia. ...
Umbilical cord bleeding was the most common clinical presentation (n: 9, ~70%) which led to the diagnosis of afibrinogenemia, while m …
Microwave regeneration of granular activated carbon saturated with PFAS.
Gagliano E, Falciglia PP, Zaker Y, Karanfil T, Roccaro P. Gagliano E, et al. Water Res. 2021 Jun 15;198:117121. doi: 10.1016/j.watres.2021.117121. Epub 2021 Apr 5. Water Res. 2021. PMID: 33910144
Moreover, the effect of MW irradiation on GAC textural properties (e.g., surface area and pore volume) was examined through N(2) adsorption isotherms. Additionally, five successive adsorption/regeneration cycles were carried out at the MW operational condition that allowed …
Moreover, the effect of MW irradiation on GAC textural properties (e.g., surface area and pore volume) was examined through N(2) adso …
Relationship Between Single-Nucleotide Polymorphisms of Tumor Necrosis Factor Alpha, Interleukin-10, Factor II and Factor V with Risk of Inhibitor Development in Patients with Severe Hemophilia A.
Soori S, Dadashizadeh G, Dorgalaleh A, Tabibian S, Keramati MR, Alizadeh S, Hosseini MS, Zaker F, Shams M. Soori S, et al. Cardiovasc Hematol Disord Drug Targets. 2019;19(3):228-232. doi: 10.2174/1871529X19666190206152315. Cardiovasc Hematol Disord Drug Targets. 2019. PMID: 30727925
METHODS: We divided 39 patients with severe HA in two groups of case (n: 19) and control (n: 20). Genotyping was performed by multiplex amplification tetra arms refractory mutation systempolymerase chain reaction (ARMS-PCR) and PCR-restriction fragment-length polymo …
METHODS: We divided 39 patients with severe HA in two groups of case (n: 19) and control (n: 20). Genotyping was performed by …
Oncogenic RAS genes impair erythroid differentiation of erythroleukaemia cells.
Zaker F, Darley RL, al Sabah A, Burnett AK. Zaker F, et al. Leuk Res. 1997 Jul;21(7):635-40. doi: 10.1016/s0145-2126(97)00022-2. Leuk Res. 1997. PMID: 9301684
We show here, for the first time, that both N-RAS and H-RAS can impair erythroid differentiation of erythroleukaemia cells induced with hexamethylene bisacetamide. ...
We show here, for the first time, that both N-RAS and H-RAS can impair erythroid differentiation of erythroleukaemia cells induced wi …