Inhibitory effect of UDP-glucose on cAMP generation and insulin secretion.
Parandeh F, Amisten S, Verma G, Mohammed Al-Amily I, Dunér P, Salehi A.
Parandeh F, et al.
J Biol Chem. 2020 Nov 6;295(45):15245-15252. doi: 10.1074/jbc.RA120.012929. Epub 2020 Aug 27.
J Biol Chem. 2020.
PMID: 32855238
Free PMC article.
Dose-dependent activation of P2Y14 by UDP-G suppressed glucose-stimulated insulin secretion (GSIS) and knockdown of P2Y14 abolished the UDP-G effect. 12-h pretreatment of human islets with pertussis-toxin (PTX) improved GSIS and prevented the inhibitory effect of UDP-G on …
Dose-dependent activation of P2Y14 by UDP-G suppressed glucose-stimulated insulin secretion (GSIS) and knockdown of P2Y14 abolished the UDP- …