FRET binding antenna reports spatiotemporal dynamics of GDI-Cdc42 GTPase interactions.
Hodgson L, Spiering D, Sabouri-Ghomi M, Dagliyan O, DerMardirossian C, Danuser G, Hahn KM.
Hodgson L, et al. Among authors: sabouri ghomi m.
Nat Chem Biol. 2016 Oct;12(10):802-809. doi: 10.1038/nchembio.2145. Epub 2016 Aug 8.
Nat Chem Biol. 2016.
PMID: 27501396
Free PMC article.
This revealed remarkably tight coordination of GTPase release and activation on a time scale of 10 s, suggesting that GDI-Cdc42 interactions are a critical component of the spatiotemporal regulation of Cdc42 activity, and not merely a mechanism for global sequestration of …
This revealed remarkably tight coordination of GTPase release and activation on a time scale of 10 s, suggesting that GDI-Cdc42 inter …