Knockdown of the mitochondria-localized protein p13 protects against experimental parkinsonism.
Inoue N, Ogura S, Kasai A, Nakazawa T, Ikeda K, Higashi S, Isotani A, Baba K, Mochizuki H, Fujimura H, Ago Y, Hayata-Takano A, Seiriki K, Shintani Y, Shintani N, Hashimoto H.
Inoue N, et al.
EMBO Rep. 2018 Mar;19(3):e44860. doi: 10.15252/embr.201744860. Epub 2018 Jan 25.
EMBO Rep. 2018.
PMID: 29371327
Free PMC article.
We show that p13 overexpression induces mitochondrial dysfunction and apoptosis. p13 knockdown attenuates toxin-induced mitochondrial dysfunction and apoptosis in dopaminergic SH-SY5Y cells via the regulation of complex I. Importantly, we generate p13-deficient mice using …
We show that p13 overexpression induces mitochondrial dysfunction and apoptosis. p13 knockdown attenuates toxin-induced mitochondrial dysfun …