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Page 1
Design and statistical principles of the SHIVA trial.
Paoletti X, Asselain B, Kamal M, Servant N, Huppé P, Bieche I, Le Tourneau C. Paoletti X, et al. Chin Clin Oncol. 2015 Sep;4(3):32. doi: 10.3978/j.issn.2304-3865.2015.02.02. Chin Clin Oncol. 2015. PMID: 26408299 Free article. Review.
However, clinical development is generally carried out according to tumor type. The SHIVA randomized trial on the contrary has been set up to investigate which of tumor biology or tumor location and histology is the most important to select treatment in patients with cance …
However, clinical development is generally carried out according to tumor type. The SHIVA randomized trial on the contrary has been s …
ShIVA: a user-friendly and interactive interface giving biologists control over their single-cell RNA-seq data.
Aussel R, Asif M, Chenag S, Jaeger S, Milpied P, Spinelli L. Aussel R, et al. Sci Rep. 2023 Sep 1;13(1):14377. doi: 10.1038/s41598-023-40959-z. Sci Rep. 2023. PMID: 37658061 Free PMC article.
For biologists lacking expert data analysis resources, the problem is even more crucial, even for the simplest single-cell transcriptomics datasets. We propose ShIVA, an interface for the analysis of single-cell RNA-seq and CITE-seq data specifically dedicated to biologist …
For biologists lacking expert data analysis resources, the problem is even more crucial, even for the simplest single-cell transcriptomics d …
SHIVA-CMB: a deep-learning-based robust cerebral microbleed segmentation tool trained on multi-source T2*GRE- and susceptibility-weighted MRI.
Tsuchida A, Goubet M, Boutinaud P, Astafeva I, Nozais V, Hervé PY, Tourdias T, Debette S, Joliot M. Tsuchida A, et al. Sci Rep. 2024 Dec 28;14(1):30901. doi: 10.1038/s41598-024-81870-5. Sci Rep. 2024. PMID: 39730628 Free PMC article.
Yet, the lack of open sharing of pre-trained models hampers the practical application and evaluation of these methods beyond specific data sources used in each study. Here, we present the SHIVA-CMB detector, a 3D Unet-based tool trained on 450 scans taken from seven acquis …
Yet, the lack of open sharing of pre-trained models hampers the practical application and evaluation of these methods beyond specific data s …
Intratumoral microbiome is driven by metastatic site and associated with immune histopathological parameters: An ancillary study of the SHIVA clinical trial.
Hilmi M, Kamal M, Vacher S, Dupain C, Ibadioune S, Halladjian M, Sablin MP, Marret G, Ajgal ZC, Nijnikoff M, Salomon A, El Beaino Z, Servant N, Dureau S, Sokol H, Nicolle R, Le Tourneau C, Bieche I, Neuzillet C. Hilmi M, et al. Eur J Cancer. 2023 Apr;183:152-161. doi: 10.1016/j.ejca.2023.01.024. Epub 2023 Feb 8. Eur J Cancer. 2023. PMID: 36868056
Molecularly targeted therapy based on tumour molecular profiling versus conventional therapy for advanced cancer (SHIVA): a multicentre, open-label, proof-of-concept, randomised, controlled phase 2 trial.
Le Tourneau C, Delord JP, Gonçalves A, Gavoille C, Dubot C, Isambert N, Campone M, Trédan O, Massiani MA, Mauborgne C, Armanet S, Servant N, Bièche I, Bernard V, Gentien D, Jezequel P, Attignon V, Boyault S, Vincent-Salomon A, Servois V, Sablin MP, Kamal M, Paoletti X; SHIVA investigators. Le Tourneau C, et al. Lancet Oncol. 2015 Oct;16(13):1324-34. doi: 10.1016/S1470-2045(15)00188-6. Epub 2015 Sep 3. Lancet Oncol. 2015. PMID: 26342236 Clinical Trial.
METHODS: The open-label, randomised, controlled phase 2 SHIVA trial was done at eight French academic centres. We included adult patients with any kind of metastatic solid tumour refractory to standard of care, provided they had an Eastern Cooperative Oncology Group perfor …
METHODS: The open-label, randomised, controlled phase 2 SHIVA trial was done at eight French academic centres. We included adult pati …
[The breakthrough of personalized medicine, new hopes and new challenges].
Flippot R, Massard C, Auclin E, Azria D, Bourien H, Rochigneux P, Schernberg A, Verlingue L, Zafrani L, Vignot S. Flippot R, et al. Bull Cancer. 2017 Sep;104(9):735-743. doi: 10.1016/j.bulcan.2017.07.003. Epub 2017 Aug 12. Bull Cancer. 2017. PMID: 28807365 Review. French.
The onset of molecular biology led to new paradigms in drug development, with efficacy data reported in early clinical trials and accelerated approvals. Multiple clinical trials, including SHIVA, SAFIR-01 and MOSCATO-01, have been developed to evaluate the interest of trea …
The onset of molecular biology led to new paradigms in drug development, with efficacy data reported in early clinical trials and accelerate …
14 results