Immune Modulation with RANKL Blockade through Denosumab Treatment in Patients with Cancer.
Chang H, Marquez J, Chen BK, Kim DM, Cheng ML, Liu EV, Yang H, Zhang L, Sinha M, Cheung A, Kwek SS, Chow ED, Bridge M, Aggarwal RR, Friedlander TW, Small EJ, Anderson M, Fong L.
Chang H, et al.
Cancer Immunol Res. 2024 Apr 2;12(4):453-461. doi: 10.1158/2326-6066.CIR-23-0184.
Cancer Immunol Res. 2024.
PMID: 38276989
Free PMC article.
These findings suggest that denosumab treatment by itself has modest immunomodulatory effects, but when combined with conventional cancer treatments, can lead to the induction of immunologic checkpoints. See related Spotlight by Nasrollahi and Davar, p. 383....
These findings suggest that denosumab treatment by itself has modest immunomodulatory effects, but when combined with conventional cancer tr …