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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1801 1
1825 1
1827 1
1830 1
1838 1
1844 3
1845 1
1848 1
1852 2
1856 1
1857 3
1858 2
1859 1
1860 1
1863 1
1866 1
1873 1
1885 1
1886 2
1887 1
1888 3
1890 2
1891 1
1892 2
1893 1
1894 2
1895 2
1896 1
1897 1
1898 1
1899 1
1900 1
1901 2
1904 1
1905 2
1906 3
1909 2
1911 1
1912 2
1914 2
1919 1
1921 2
1922 3
1923 2
1924 2
1925 4
1926 3
1927 2
1928 3
1930 2
1931 3
1932 3
1933 8
1934 6
1935 3
1936 8
1937 2
1938 3
1939 2
1940 2
1941 9
1942 3
1943 6
1944 4
1945 10
1946 32
1947 33
1948 33
1949 16
1950 25
1951 26
1952 36
1953 52
1954 29
1955 36
1956 32
1957 43
1958 39
1959 32
1960 51
1961 58
1962 57
1963 86
1964 77
1965 80
1966 96
1967 123
1968 124
1969 152
1970 156
1971 131
1972 140
1973 201
1974 210
1975 221
1976 239
1977 256
1978 267
1979 285
1980 268
1981 349
1982 332
1983 374
1984 396
1985 476
1986 513
1987 555
1988 724
1989 710
1990 808
1991 930
1992 969
1993 1053
1994 1247
1995 1401
1996 1616
1997 1827
1998 2092
1999 2390
2000 2783
2001 3103
2002 3721
2003 4152
2004 4704
2005 5670
2006 6123
2007 6653
2008 7111
2009 7786
2010 8795
2011 9922
2012 11118
2013 12411
2014 13670
2015 14883
2016 15795
2017 16932
2018 17745
2019 19563
2020 23903
2021 28027
2022 29411
2023 27463
2024 28413
2025 4918

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313,804 results

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Page 1
COX 2-inhibitors; a thorough and updated survey into combinational therapies in cancers.
Rodrigues P, Bangali H, Hammoud A, Mustafa YF, Al-Hetty HRAK, Alkhafaji AT, Deorari MM, Al-Taee MM, Zabibah RS, Alsalamy A. Rodrigues P, et al. Med Oncol. 2024 Jan 2;41(1):41. doi: 10.1007/s12032-023-02256-7. Med Oncol. 2024. PMID: 38165473 Review.
Cyclooxygenase (COX) enzymes are pivotal in inflammation and cancer development. COX-2, in particular, has been implicated in tumor growth, angiogenesis, and immune evasion. ...In this study, a literature search of all major academic databases was conducted (PubMed, …
Cyclooxygenase (COX) enzymes are pivotal in inflammation and cancer development. COX-2, in particular, has been implicated in …
Natural Product Inhibitors of Cyclooxygenase (COX) Enzyme: A Review on Current Status and Future Perspectives.
Ambati GG, Jachak SM. Ambati GG, et al. Curr Med Chem. 2021;28(10):1877-1905. doi: 10.2174/0929867327666200602131100. Curr Med Chem. 2021. PMID: 32484764 Review.
BACKGROUND: Several clinically used COX-1 and COX-2 inhibitor drugs were reported to possess severe side effects like GI ulcers and cardiovascular disturbances, respectively. ...METHODS: Various in vitro, in vivo and in silico standardized methods were used to evalu …
BACKGROUND: Several clinically used COX-1 and COX-2 inhibitor drugs were reported to possess severe side effects like GI ulcer …
Cyclooxygenase-1 (COX-1) and COX-1 Inhibitors in Cancer: A Review of Oncology and Medicinal Chemistry Literature.
Pannunzio A, Coluccia M. Pannunzio A, et al. Pharmaceuticals (Basel). 2018 Oct 11;11(4):101. doi: 10.3390/ph11040101. Pharmaceuticals (Basel). 2018. PMID: 30314310 Free PMC article. Review.
Prostaglandins and thromboxane are lipid signaling molecules deriving from arachidonic acid by the action of the cyclooxygenase isoenzymes COX-1 and COX-2. The role of cyclooxygenases (particularly COX-2) and prostaglandins (particularly PGE2) in cancer-relat …
Prostaglandins and thromboxane are lipid signaling molecules deriving from arachidonic acid by the action of the cyclooxygenase isoenzymes …
The role of COX expression in the prognostication of overall survival of canine and feline cancer: A systematic review.
Gregório H, Magalhães TR, Pires I, Prada J, Carvalho MI, Queiroga FL. Gregório H, et al. Vet Med Sci. 2021 Jul;7(4):1107-1119. doi: 10.1002/vms3.460. Epub 2021 Mar 10. Vet Med Sci. 2021. PMID: 33751829 Free PMC article.
Cyclooxygenase (COX) isoforms-1 and -2 have been extensively investigated in cancer. Although COX-2 is the isoform most studied and has been described in several malignancies associated with histologic criteria of malignancy and worse prognosis, COX-1 has als …
Cyclooxygenase (COX) isoforms-1 and -2 have been extensively investigated in cancer. Although COX-2 is the isoform most studie …
Lessons from 20 years with COX-2 inhibitors: Importance of dose-response considerations and fair play in comparative trials.
Stiller CO, Hjemdahl P. Stiller CO, et al. J Intern Med. 2022 Oct;292(4):557-574. doi: 10.1111/joim.13505. Epub 2022 May 31. J Intern Med. 2022. PMID: 35585779 Free article. Review.
Identification of two isoforms of COX, COX-1 and COX-2, led to the development of selective COX-2 inhibitors, which were launched as having fewer gastrointestinal side effects since gastroprotective prostaglandins produced via COX-1 are spared. …
Identification of two isoforms of COX, COX-1 and COX-2, led to the development of selective COX-2 inhibitors, wh …
A mechanistic perspective on the specificity and extent of COX-2 inhibition in pregnancy.
Chan VS. Chan VS. Drug Saf. 2004;27(7):421-6. doi: 10.2165/00002018-200427070-00001. Drug Saf. 2004. PMID: 15141994 Review.
Despite the known reproductive toxicity of NSAIDs, which are nonspecific COX inhibitors, little is known about the differential role between COX-1 and COX-2 inhibition on reproduction. ...There is growing evidence to suggest that the inducible COX-2, r …
Despite the known reproductive toxicity of NSAIDs, which are nonspecific COX inhibitors, little is known about the differential role …
Is COX-2 a 'collateral' target in cancer prevention?
Kashfi K, Rigas B. Kashfi K, et al. Biochem Soc Trans. 2005 Aug;33(Pt 4):724-7. doi: 10.1042/BST0330724. Biochem Soc Trans. 2005. PMID: 16042585 Review.
Evidence suggests that COX-2 may not be the only, or the ideal, target for cancer prevention; for example, COX-2 is not expressed in human aberrant crypt foci, the earliest recognizable pre-malignant lesion in the colon; COX-2 is expressed in less than half o …
Evidence suggests that COX-2 may not be the only, or the ideal, target for cancer prevention; for example, COX-2 is not expres …
Role and regulation of cyclooxygenase-2 during inflammation.
Simon LS. Simon LS. Am J Med. 1999 May 31;106(5B):37S-42S. doi: 10.1016/s0002-9343(99)00115-1. Am J Med. 1999. PMID: 10390126 Review.
Prostaglandins are formed from arachidonic acid by the action of cyclooxygenase (COX) and subsequent downstream synthetases. Recently, it has been found that there are two closely related forms of COX, which are now known as COX-1 and COX-2. ...All con …
Prostaglandins are formed from arachidonic acid by the action of cyclooxygenase (COX) and subsequent downstream synthetases. Recently …
Is COX-2 inhibition a panacea for cancer prevention?
Vainio H. Vainio H. Int J Cancer. 2001 Dec 1;94(5):613-4. doi: 10.1002/ijc.1518. Int J Cancer. 2001. PMID: 11745453 Review.
The epidemiologic evidence and rodent studies suggest strongly that nonselective inhibitors of cyclooxygenase (COX) enzymes such as aspirin, inhibiting both COX-1 and COX-2 isoforms, reduce the incidence of and mortality from intestinal tumors. Genetically ma …
The epidemiologic evidence and rodent studies suggest strongly that nonselective inhibitors of cyclooxygenase (COX) enzymes such as a …
Colorectal Carcinoma, Cyclooxygenases, and COX Inhibitors.
Ganduri V, Rajasekaran K, Duraiyarasan S, Adefuye MA, Manjunatha N. Ganduri V, et al. Cureus. 2022 Aug 30;14(8):e28579. doi: 10.7759/cureus.28579. eCollection 2022 Aug. Cureus. 2022. PMID: 36185863 Free PMC article. Review.
Therefore, COX inhibition by non-steroidal anti-inflammatory drugs (NSAIDs) targeted against both the isoforms COX-1 and COX-2 have been studied for decades in anticipation of preventing the occurrence of colorectal carcinoma in high-risk populations. This ar …
Therefore, COX inhibition by non-steroidal anti-inflammatory drugs (NSAIDs) targeted against both the isoforms COX-1 and CO
313,804 results
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