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Tension induces a base-paired overstretched DNA conformation.
Bosaeus N, El-Sagheer AH, Brown T, Smith SB, Akerman B, Bustamante C, Nordén B. Bosaeus N, et al. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15179-84. doi: 10.1073/pnas.1213172109. Epub 2012 Sep 4. Proc Natl Acad Sci U S A. 2012. PMID: 22949705 Free PMC article.
Since its initial discovery 15 y ago, a debate has arisen as to whether the molecule adopts a new form [Cluzel P, et al. (1996) Science 271:792-794; Smith SB, Cui Y, Bustamante C (1996) Science 271:795-799], or simply denatures under tension [van Mameren J, et al. (2009) P …
Since its initial discovery 15 y ago, a debate has arisen as to whether the molecule adopts a new form [Cluzel P, et al. (1996) Science 271: …