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Understanding paralogous epilepsy-associated GABAA receptor variants: Clinical implications, mechanisms, and potential pitfalls.
Kan ASH, Kusay AS, Mohammadi NA, Lin SXN, Liao VWY, Lesca G, Souci S, Milh M, Christophersen P, Chebib M, Møller RS, Absalom NL, Jensen AA, Ahring PK. Kan ASH, et al. Proc Natl Acad Sci U S A. 2024 Dec 10;121(50):e2413011121. doi: 10.1073/pnas.2413011121. Epub 2024 Dec 6. Proc Natl Acad Sci U S A. 2024. PMID: 39642202 Free PMC article.
These findings establish that paralogous variants affecting the 100% conserved proline residue in the M1 transmembrane helix of GABA(A)R subunits all lead to overall GOF traits. The unexpected asymmetric and mixed effects on receptor function have broader implications for …
These findings establish that paralogous variants affecting the 100% conserved proline residue in the M1 transmembrane helix of GABA(A)R …
Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
GBD 2023 Disease and Injury and Risk Factor Collaborators. GBD 2023 Disease and Injury and Risk Factor Collaborators. Lancet. 2025 Oct 18;406(10513):1873-1922. doi: 10.1016/S0140-6736(25)01637-X. Epub 2025 Oct 12. Lancet. 2025. PMID: 41092926 Free PMC article.
Association of Endothelial Dysfunction With Chronic Marijuana Smoking and THC-Edible Use.
Mohammadi L, Navabzadeh M, Jiménez-Téllez N, Han DD, Reagan E, Naughton J, Zhou LY, Almeida R, Castaneda LM, Abdelaal SA, Park KS, Uyemura K, Cheung CP, Onder MN, Goyal N, Rao P, Hellman J, Cheng J, Wu JC, Marcus GM, Springer ML. Mohammadi L, et al. JAMA Cardiol. 2025 Aug 1;10(8):851-855. doi: 10.1001/jamacardio.2025.1399. JAMA Cardiol. 2025. PMID: 40434782 Free PMC article.
FMD was inversely correlated with smoking frequency (r = -0.7; P < .001) and the amount of THC ingested (r = -0.7; P = .03). Other vascular properties showed no differences. ...

FMD was inversely correlated with smoking frequency (r = -0.7; P < .001) and the amount of THC ingested (r = -0.7; P = .03)

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GDF8 and activin A are the key negative regulators of muscle mass in postmenopausal females: a randomized phase I trial.
Gonzalez Trotter D, Donahue S, Wynne C, Ali S, Parasoglou P, Boyapati A, Mohammadi K, Musser BJ, Meier P, Mastaitis J, Sleeman MW, Glass DJ, Gasparino E, Trejos J, Davis JD, Hirshberg B, Pordy R, Yancopoulos GD, Herman GA. Gonzalez Trotter D, et al. Nat Commun. 2025 May 13;16(1):4376. doi: 10.1038/s41467-025-59380-3. Nat Commun. 2025. PMID: 40360471 Free PMC article. Clinical Trial.
Global burden of enteric infectious diseases, diarrhoeal diseases, and corresponding aetiologies, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
GBD 2023 Diarrhoeal Disease and Enteric Infectious Diseases Collaborators. GBD 2023 Diarrhoeal Disease and Enteric Infectious Diseases Collaborators. Lancet Infect Dis. 2026 Jun 2:S1473-3099(26)00194-5. doi: 10.1016/S1473-3099(26)00194-5. Online ahead of print. Lancet Infect Dis. 2026. PMID: 42229499
34 results