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Identification of a phorbol ester-repressible v-src-inducible gene.
Simmons DL, Levy DB, Yannoni Y, Erikson RL. Simmons DL, et al. Proc Natl Acad Sci U S A. 1989 Feb;86(4):1178-82. doi: 10.1073/pnas.86.4.1178. Proc Natl Acad Sci U S A. 1989. PMID: 2537491 Free PMC article.
By subtractive and differential screening, we have cloned 12 of these sequences, 2 of which were c-fos and krox-24. Serum induced all the v-src-inducible genes tested, suggesting that these genes serve roles in normal cell division and are not specific to transformation pe …
By subtractive and differential screening, we have cloned 12 of these sequences, 2 of which were c-fos and krox-24. Serum induced all the …
Inherited human RelB deficiency impairs innate and adaptive immunity to infection.
Le Voyer T, Maglorius Renkilaraj MRL, Moriya K, Pérez Lorenzo M, Nguyen T, Gao L, Rubin T, Cederholm A, Ogishi M, Arango-Franco CA, Béziat V, Lévy R, Migaud M, Rapaport F, Itan Y, Deenick EK, Cortese I, Lisco A, Boztug K, Abel L, Boisson-Dupuis S, Boisson B, Frosk P, Ma CS, Landegren N, Celmeli F, Casanova JL, Tangye SG, Puel A. Le Voyer T, et al. Proc Natl Acad Sci U S A. 2024 Sep 10;121(37):e2321794121. doi: 10.1073/pnas.2321794121. Epub 2024 Sep 4. Proc Natl Acad Sci U S A. 2024. PMID: 39231201 Free PMC article.
We report two unrelated adults with homozygous (P1) or compound heterozygous (P2) private loss-of-function variants of V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB). The resulting deficiency of functional RelB impairs the induction of NFKB2 mRNA and NF-kappaB …
We report two unrelated adults with homozygous (P1) or compound heterozygous (P2) private loss-of-function variants of V-Rel Reticulo …
Marek's disease virus Meq transforms chicken cells via the v-Jun transcriptional cascade: a converging transforming pathway for avian oncoviruses.
Levy AM, Gilad O, Xia L, Izumiya Y, Choi J, Tsalenko A, Yakhini Z, Witter R, Lee L, Cardona CJ, Kung HJ. Levy AM, et al. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14831-6. doi: 10.1073/pnas.0506849102. Epub 2005 Oct 3. Proc Natl Acad Sci U S A. 2005. PMID: 16203997 Free PMC article.
We found that Meq transforms DF-1, with a cell morphology akin to v-Jun and v-Ski transformed cells, and protects DF-1 from apoptosis, and the transformed cells are tumorigenic in chorioallantoic membrane assay. Significantly, using microarray and RT-PCR analyses, w …
We found that Meq transforms DF-1, with a cell morphology akin to v-Jun and v-Ski transformed cells, and protects DF-1 from ap …
A domain of human immunodeficiency virus type 1 Vpr containing repeated H(S/F)RIG amino acid motifs causes cell growth arrest and structural defects.
Macreadie IG, Castelli LA, Hewish DR, Kirkpatrick A, Ward AC, Azad AA. Macreadie IG, et al. Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2770-4. doi: 10.1073/pnas.92.7.2770. Proc Natl Acad Sci U S A. 1995. PMID: 7708721 Free PMC article.
A protein with functions relating to the yeast cytoskeleton, Sac1p [Cleves, A. E., Novick, P.J. & Bankaitis, V.A. (1989) J. Cell Biol. 109, 2939-2950], shows sequence similarity to Vpr, and Vpr's effect in yeast may be to disrupt normal Sac1p functions. The Sac1p equiv …
A protein with functions relating to the yeast cytoskeleton, Sac1p [Cleves, A. E., Novick, P.J. & Bankaitis, V.A. (1989) J. Cell …
Mutation in a reporter gene depends on proximity to and transcription of immunoglobulin variable transgenes.
Umar A, Schweitzer PA, Levy NS, Gearhart JD, Gearhart PJ. Umar A, et al. Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4902-6. doi: 10.1073/pnas.88.11.4902. Proc Natl Acad Sci U S A. 1991. PMID: 1905016 Free PMC article.
Somatic mutation in immunoglobulin genes is localized to a 2-kilobase region of DNA surrounding and including rearranged variable (V), diversity, and joining (J) gene segments encoding heavy and light chains. To examine the structural basis for targeted mutation, we develo …
Somatic mutation in immunoglobulin genes is localized to a 2-kilobase region of DNA surrounding and including rearranged variable (V) …
Sporadicity: Between periodic and chaotic dynamical behaviors.
Gaspard P, Wang XJ. Gaspard P, et al. Proc Natl Acad Sci U S A. 1988 Jul;85(13):4591-5. doi: 10.1073/pnas.85.13.4591. Proc Natl Acad Sci U S A. 1988. PMID: 16593949 Free PMC article.

Press, Cambridge, U.K.)] as well as the logarithm of separation of initially nearby trajectories grow as n(v(0) )(log n)(v(1) ) with 0 < v(0) < 1 or v(0) = 1 and v(1) < 0 as time n --> infinity. These systems present a behavior inter

…
Press, Cambridge, U.K.)] as well as the logarithm of separation of initially nearby trajectories grow as n(v(0) )(log n)(v(1) …
mRNA vaccination with charge-altering releasable transporters elicits human T cell responses and cures established tumors in mice.
Haabeth OAW, Blake TR, McKinlay CJ, Waymouth RM, Wender PA, Levy R. Haabeth OAW, et al. Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9153-E9161. doi: 10.1073/pnas.1810002115. Epub 2018 Sep 10. Proc Natl Acad Sci U S A. 2018. PMID: 30201728 Free PMC article.
In an established mouse model, we demonstrate that CARTs preferentially target professional APCs in secondary lymphoid organs upon i.v. injections and target local APCs upon s.c. injection. Finally, we show that CARTs coformulated with mRNA and a Toll-like receptor ligand …
In an established mouse model, we demonstrate that CARTs preferentially target professional APCs in secondary lymphoid organs upon i.v …
Fronts in anomalous diffusion-reaction systems.
Volpert VA, Nec Y, Nepomnyashchy AA. Volpert VA, et al. Philos Trans A Math Phys Eng Sci. 2013 Jan 13;371(1982):20120179. doi: 10.1098/rsta.2012.0179. Philos Trans A Math Phys Eng Sci. 2013. PMID: 23185056 Review.
A number of models of anomalous diffusion with reaction are discussed, including models with Levy flights, truncated Levy flights, subdiffusion-limited reactions and models with intertwined subdiffusion and reaction operators....
A number of models of anomalous diffusion with reaction are discussed, including models with Levy flights, truncated Levy flig …
Macrophage migration inhibitory factor (MIF) is a critical mediator of the innate immune response to Mycobacterium tuberculosis.
Das R, Koo MS, Kim BH, Jacob ST, Subbian S, Yao J, Leng L, Levy R, Murchison C, Burman WJ, Moore CC, Scheld WM, David JR, Kaplan G, MacMicking JD, Bucala R. Das R, et al. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):E2997-3006. doi: 10.1073/pnas.1301128110. Epub 2013 Jul 23. Proc Natl Acad Sci U S A. 2013. PMID: 23882081 Free PMC article.
To determine mechanisms for MIF's protective role, we studied both aerosolized and i.v. models of mycobacterial infection and observed MIF-deficient mice to succumb more quickly with higher organism burden, increased lung pathology, and decreased innate cytokine production …
To determine mechanisms for MIF's protective role, we studied both aerosolized and i.v. models of mycobacterial infection and observe …
An inherited LMNA gene mutation in atypical Progeria syndrome.
Doubaj Y, De Sandre-Giovannoli A, Vera EV, Navarro CL, Elalaoui SC, Tajir M, Lévy N, Sefiani A. Doubaj Y, et al. Am J Med Genet A. 2012 Nov;158A(11):2881-7. doi: 10.1002/ajmg.a.35557. Epub 2012 Sep 18. Am J Med Genet A. 2012. PMID: 22991222
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