Structure of 5-hydroxymethylcytosine-specific restriction enzyme, AbaSI, in complex with DNA.
Horton JR, Borgaro JG, Griggs RM, Quimby A, Guan S, Zhang X, Wilson GG, Zheng Y, Zhu Z, Cheng X.
Horton JR, et al.
Nucleic Acids Res. 2014 Jul;42(12):7947-59. doi: 10.1093/nar/gku497. Epub 2014 Jun 3.
Nucleic Acids Res. 2014.
PMID: 24895434
Free PMC article.
AbaSI has been used as a tool for mapping the genomic locations of 5hmC, an important epigenetic modification in the DNA of higher organisms. ...AbaSI appears to be mainly a homodimer in solution, but interacts with DNA in our structures as a homotetramer. ...
AbaSI has been used as a tool for mapping the genomic locations of 5hmC, an important epigenetic modification in the DNA of higher or …