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Page 1
The NIH Somatic Cell Genome Editing program.
Saha K, Sontheimer EJ, Brooks PJ, Dwinell MR, Gersbach CA, Liu DR, Murray SA, Tsai SQ, Wilson RC, Anderson DG, Asokan A, Banfield JF, Bankiewicz KS, Bao G, Bulte JWM, Bursac N, Campbell JM, Carlson DF, Chaikof EL, Chen ZY, Cheng RH, Clark KJ, Curiel DT, Dahlman JE, Deverman BE, Dickinson ME, Doudna JA, Ekker SC, Emborg ME, Feng G, Freedman BS, Gamm DM, Gao G, Ghiran IC, Glazer PM, Gong S, Heaney JD, Hennebold JD, Hinson JT, Khvorova A, Kiani S, Lagor WR, Lam KS, Leong KW, Levine JE, Lewis JA, Lutz CM, Ly DH, Maragh S, McCray PB Jr, McDevitt TC, Mirochnitchenko O, Morizane R, Murthy N, Prather RS, Ronald JA, Roy S, Roy S, Sabbisetti V, Saltzman WM, Santangelo PJ, Segal DJ, Shimoyama M, Skala MC, Tarantal AF, Tilton JC, Truskey GA, Vandsburger M, Watts JK, Wells KD, Wolfe SA, Xu Q, Xue W, Yi G, Zhou J; SCGE Consortium. Saha K, et al. Nature. 2021 Apr;592(7853):195-204. doi: 10.1038/s41586-021-03191-1. Epub 2021 Apr 7. Nature. 2021. PMID: 33828315 Free PMC article. Review.
Activities and polymorphisms of MMP-2 and MMP-9, smoking, diabetes and risk of prostate cancer.
Kiani A, Kamankesh M, Vaisi-Raygani A, Moradi MR, Tanhapour M, Rahimi Z, Elahi-Rad S, Bahrehmand F, Aliyari M, Aghaz F, Mozafari H, Rezvani N, Haghnazari L, Pourmotabbed T. Kiani A, et al. Mol Biol Rep. 2020 Dec;47(12):9373-9383. doi: 10.1007/s11033-020-05968-5. Epub 2020 Nov 9. Mol Biol Rep. 2020. PMID: 33165815
Covariates were considered as age, status of cigarette smoking, and a possible history of diabetes mellitus (DM). The frequency of -1575 MMP-2 A/A + A/G and -1562 MMP-9 C/T + T/T genotypes were higher in PCa-patients with DM (74.3%,p = 0.003) and with smoking …
Covariates were considered as age, status of cigarette smoking, and a possible history of diabetes mellitus (DM). The frequency of -1575 MMP …
Paraoxonase 1 (PON1) 55 polymorphism, lipid profiles and psoriasis.
Asefi M, Vaisi-Raygani A, Bahrehmand F, Kiani A, Rahimi Z, Nomani H, Ebrahimi A, Tavilani H, Pourmotabbed T. Asefi M, et al. Br J Dermatol. 2012 Dec;167(6):1279-86. doi: 10.1111/j.1365-2133.2012.11170.x. Br J Dermatol. 2012. PMID: 22835076
CONCLUSIONS: The PON1 55 M allele is a risk factor for psoriasis. Carriers of this allele have high levels of MDA, APOB and LP(a), a high APOB/APOA1 ratio and low ARE activity. These results indicate that oxidative stress, impairment of the antioxidant system and ab …
CONCLUSIONS: The PON1 55 M allele is a risk factor for psoriasis. Carriers of this allele have high levels of MDA, APOB and LP(a), …
The role of caveolin-1 and endothelial nitric oxide synthase polymorphisms in susceptibility to prostate cancer.
Aliyari M, Elieh Ali Komi D, Kiani A, Moradi M, Tanhapour M, Rahimi Z, Mozafari H, Mohammadi-Noori E, Pourmotabbed T, Vaisi-Raygani A, Bahrehmand F. Aliyari M, et al. Int J Exp Pathol. 2021 Dec;102(6):260-267. doi: 10.1111/iep.12394. Epub 2021 May 8. Int J Exp Pathol. 2021. PMID: 33964050 Free PMC article.
Serum levels of NO2- and NO3- were measured using spectrophotometry, and serum levels of testosterone and PSA were measured by ELISA. The frequencies of CAV1 genotypes A/T vs. A/A according to the dominant model AT + TT vs. AA genotype and T allele were significantl …
Serum levels of NO2- and NO3- were measured using spectrophotometry, and serum levels of testosterone and PSA were measured by ELISA. The fr …
Cytotoxic T Lymphocyte Antigen-4 Gene Variants in Type 2 Diabetic Patients with or without Neuropathy.
Kiani J, Khadempar S, Hajilooi M, Rezaei H, Keshavarzi F, Solgi G. Kiani J, et al. Iran J Allergy Asthma Immunol. 2016 Jun;15(3):220-8. Iran J Allergy Asthma Immunol. 2016. PMID: 27424137 Free article. Clinical Trial.
The dimorphisms at -1722 (C/T), -318 (C/T) and +49 (A/G) for CTLA-4 gene were determined using ARMS-PCR. The CTLA-4 (+49 G/G) and (+49 A/A) genotypes were found to be positively and negatively associated with T2D, respectively (p=0.03). ...Genotypes distribution amo …
The dimorphisms at -1722 (C/T), -318 (C/T) and +49 (A/G) for CTLA-4 gene were determined using ARMS-PCR. The CTLA-4 (+49 G/G) and (+49 A …
Matrix metalloproteinase-2 functional promoter polymorphism G1575A is associated with elevated circulatory MMP-2 levels and increased risk of cardiovascular disease in systemic lupus erythematosus patients.
Bahrehmand F, Vaisi-Raygani A, Kiani A, Rahimi Z, Tavilani H, Navabi SJ, Shakiba E, Hassanzadeh N, Pourmotabbed T. Bahrehmand F, et al. Lupus. 2012 May;21(6):616-24. doi: 10.1177/0961203312436857. Epub 2012 Feb 9. Lupus. 2012. PMID: 22323339
The presence of MMP-2 G1575A allele was found to be associated with SLE and developed CVD (OR = 1.78, p = 0.029 and OR = 3.43, p = 0.025, respectively). The SLE patients with MMP-2 A (G/A + A/A) allele had higher MMP-2 activity (301 166 vs. 194 35.5, p = 0.00 …
The presence of MMP-2 G1575A allele was found to be associated with SLE and developed CVD (OR = 1.78, p = 0.029 and OR = 3.43, p = 0.025, re …