Quantitative assessment of cell fate decision between autophagy and apoptosis.
Liu B, Oltvai ZN, Bayır H, Silverman GA, Pak SC, Perlmutter DH, Bahar I.
Liu B, et al.
Sci Rep. 2017 Dec 14;7(1):17605. doi: 10.1038/s41598-017-18001-w.
Sci Rep. 2017.
PMID: 29242632
Free PMC article.
The model reveals that cytoplasmic Ca(2+) acts as a rheostat that fine-tunes autophagic and apoptotic responses. A G-protein signaling-mediated feedback loop maintains cytoplasmic Ca(2+) level, which in turn governs autophagic response through an AMP-activated prote …
The model reveals that cytoplasmic Ca(2+) acts as a rheostat that fine-tunes autophagic and apoptotic responses. A G-protein s …