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Common low-density lipoprotein receptor p.G116S variant has a large effect on plasma low-density lipoprotein cholesterol in circumpolar inuit populations.
Dubé JB, Wang J, Cao H, McIntyre AD, Johansen CT, Hopkins SE, Stringer R, Hosseinzadeh S, Kennedy BA, Ban MR, Young TK, Connelly PW, Dewailly E, Bjerregaard P, Boyer BB, Hegele RA. Dubé JB, et al. Circ Cardiovasc Genet. 2015 Feb;8(1):100-5. doi: 10.1161/CIRCGENETICS.114.000646. Epub 2014 Nov 20. Circ Cardiovasc Genet. 2015. PMID: 25414273 Free PMC article. Clinical Trial.