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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1812 1
1880 2
1887 1
1890 1
1891 1
1897 1
1902 1
1912 1
1914 1
1918 1
1919 1
1921 1
1922 2
1926 1
1927 1
1932 1
1939 1
1940 1
1941 1
1942 1
1943 1
1944 1
1946 1
1947 4
1948 1
1950 4
1951 3
1952 3
1953 9
1954 4
1956 2
1957 6
1958 6
1959 7
1960 10
1961 5
1962 9
1963 36
1964 31
1965 27
1966 24
1967 40
1968 34
1969 46
1970 34
1971 26
1972 23
1973 18
1974 12
1975 25
1976 29
1977 32
1978 19
1979 39
1980 42
1981 55
1982 57
1983 55
1984 51
1985 53
1986 56
1987 80
1988 81
1989 109
1990 111
1991 112
1992 105
1993 104
1994 114
1995 117
1996 124
1997 141
1998 137
1999 137
2000 182
2001 212
2002 228
2003 216
2004 234
2005 260
2006 282
2007 323
2008 333
2009 369
2010 380
2011 424
2012 483
2013 507
2014 907
2015 1092
2016 1165
2017 1213
2018 1295
2019 1496
2020 1897
2021 2132
2022 2200
2023 2253
2024 2573
2025 1087

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23,571 results

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The following term was not found in PubMed: Gharighoran
Page 1
Nonsedating anxiolytics.
Cerne R, Smith JL, Chrzanowska A, Lippa A. Cerne R, et al. Pharmacol Biochem Behav. 2024 Dec;245:173895. doi: 10.1016/j.pbb.2024.173895. Epub 2024 Oct 24. Pharmacol Biochem Behav. 2024. PMID: 39461622 Review.
While the GABA(A)R PAMs possess remarkable anxiolytic efficacy, they have fallen out of favor due to a host of adverse effects including sedation, motor impairment, addictive potential and tolerance development. ...Thus, KRM-II-81 is a newly discovered, non- BZD anx …
While the GABA(A)R PAMs possess remarkable anxiolytic efficacy, they have fallen out of favor due to a host of adverse effects …
The TMEM132B-GABAA receptor complex controls alcohol actions in the brain.
Wang G, Peng S, Reyes Mendez M, Keramidas A, Castellano D, Wu K, Han W, Tian Q, Dong L, Li Y, Lu W. Wang G, et al. Cell. 2024 Nov 14;187(23):6649-6668.e35. doi: 10.1016/j.cell.2024.09.006. Epub 2024 Oct 1. Cell. 2024. PMID: 39357522 Free article.
Here, we have discovered a transmembrane protein TMEM132B that is a GABA(A) receptor (GABA(A)R) auxiliary subunit. Functionally, TMEM132B promotes GABA(A)R expression at the cell surface, slows receptor deactivation, and enhances the allosteric effects …
Here, we have discovered a transmembrane protein TMEM132B that is a GABA(A) receptor (GABA(A)R) auxiliary subunit. Functionall …
gamma2 GABA(A)R Trafficking and the Consequences of Human Genetic Variation.
Lorenz-Guertin JM, Bambino MJ, Jacob TC. Lorenz-Guertin JM, et al. Front Cell Neurosci. 2018 Aug 23;12:265. doi: 10.3389/fncel.2018.00265. eCollection 2018. Front Cell Neurosci. 2018. PMID: 30190672 Free PMC article. Review.
Fundamental structure-function studies and cellular pathology investigations have revealed dynamic GABA(A)R trafficking and synaptic scaffolding as critical regulators of GABAergic inhibition. ...We then examine gamma2 subunit human genetic variation and assess dise …
Fundamental structure-function studies and cellular pathology investigations have revealed dynamic GABA(A)R trafficking and sy …
Cy5.5-3-Benzo[1,3]dioxol-5-yl-5-hydroxy-5-(4-methoxyphenyl)-4-(3,4,5-trimethoxybenzyl)-5H-furan-2-one).
Leung K. Leung K. 2009 Aug 12 [updated 2009 Sep 30]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. 2009 Aug 12 [updated 2009 Sep 30]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641539 Free Books & Documents. Review.
Positron emission tomography (13) is a sensitive imaging technique for investigation of the ETRs in a small animal model (12, 14-16). (18)F-Labeled ET-1 was among the first ligands developed for in vivo PET study of these receptors (14, 17). ET(A)R has been found to …
Positron emission tomography (13) is a sensitive imaging technique for investigation of the ETRs in a small animal model (12, 14-16). (18)F- …
Targeting the Endothelin A Receptor in IgA Nephropathy.
Kohan DE, Barratt J, Heerspink HJL, Campbell KN, Camargo M, Ogbaa I, Haile-Meskale R, Rizk DV, King A. Kohan DE, et al. Kidney Int Rep. 2023 Aug 4;8(11):2198-2210. doi: 10.1016/j.ekir.2023.07.023. eCollection 2023 Nov. Kidney Int Rep. 2023. PMID: 38025243 Free PMC article. Review.
The latest addition to this therapeutic armamentarium targets the endothelin-A receptor (ET(A)R). Activation of ET(A)R on multiple renal cell types elicits a host of pathophysiological effects, including vasoconstriction, cell proliferation, inflammati …
The latest addition to this therapeutic armamentarium targets the endothelin-A receptor (ET(A)R). Activation of ET(A) …
Take C.A.R.E of patient safety: A call to action.
Kim ARJ, Chew KS, Ngian HU. Kim ARJ, et al. Med J Malaysia. 2024 Nov;79(6):800-802. Med J Malaysia. 2024. PMID: 39614801 Free article.
In a dynamic healthcare environment, patient safety is crucial. A "Conscious Actions Reduce Errors" (C.A.R.E) approach is needed to safeguard safety and reduce medical errors. The dual process theory highlights two thinking modes: intuitive (fast, automatic) and ana …
In a dynamic healthcare environment, patient safety is crucial. A "Conscious Actions Reduce Errors" (C.A.R.E) approach is need …
Drugs in Development to Manage Acute Pain.
Oliver B, Devitt C, Park G, Razak A, Liu SM, Bergese SD. Oliver B, et al. Drugs. 2025 Jan;85(1):11-19. doi: 10.1007/s40265-024-02118-0. Epub 2024 Nov 19. Drugs. 2025. PMID: 39560856 Review.
W.A.R.A. (Wiring Affect with Reattach) Provided by Remote Training: First-Aid Psychological Intervention?
Weerkamp-Bartholomeus P, Marazziti D, van Amelsvoort T. Weerkamp-Bartholomeus P, et al. Clin Neuropsychiatry. 2020 Apr;17(2):115-116. doi: 10.36131/CN20200217. Clin Neuropsychiatry. 2020. PMID: 34908981 Free PMC article.
The benefits of W.A.R.A. are that the intervention is light, brief, and simple in helping to process negative affect. ...We immediately started to give access to free online W.A.R.A. training, so professionals, worldwide, can offer W.A.R. …
The benefits of W.A.R.A. are that the intervention is light, brief, and simple in helping to process negative affect. ...We im …
Clinical applications of small-molecule GABA(A)R modulators for neurological disorders.
Chen G, Xu M, Chen Z, Yang F. Chen G, et al. Bioorg Chem. 2024 Dec;153:107983. doi: 10.1016/j.bioorg.2024.107983. Epub 2024 Nov 22. Bioorg Chem. 2024. PMID: 39581171 Review.
Gamma-aminobutyric acid type A receptor (GABA(A)R) modulators are crucial in treating neurological and psychiatric disorders, including epilepsy, anxiety, insomnia, and depression. This review examines the synthetic approaches and clinical applications of representa …
Gamma-aminobutyric acid type A receptor (GABA(A)R) modulators are crucial in treating neurological and psychiatric disorders, …
14-3-3zeta Mediates GABA(A)R Activation by Interacting with BIG1.
Li C, Huang S, Peng J, Hong T, Zhou C, Tang J. Li C, et al. Mol Neurobiol. 2023 Mar;60(3):1721-1732. doi: 10.1007/s12035-022-03172-z. Epub 2022 Dec 23. Mol Neurobiol. 2023. PMID: 36562883
Overexpression of 14-3-3zeta-WT increased the surface expression of BIG1 in dendrites and axons, as well as the binding of BIG1 with GABA(A)R. Depleted 14-3-3zeta with efficacious siRNA attenuated the interaction between BIG1 and GABA(A)Rs and resulted in significan …
Overexpression of 14-3-3zeta-WT increased the surface expression of BIG1 in dendrites and axons, as well as the binding of BIG1 with GABA( …
23,571 results
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