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Endogenous neurosteroids influence synaptic GABAA receptors during postnatal development.
Belelli D, Brown AR, Mitchell SJ, Gunn BG, Herd MB, Phillips GD, Seifi M, Swinny JD, Lambert JJ. Belelli D, et al. J Neuroendocrinol. 2018 Feb;30(2). doi: 10.1111/jne.12537. J Neuroendocrinol. 2018. PMID: 28905487 Review.
Conventionally, programmed expression changes to the subtype of synaptic GABA(A) R are primarily implicated in this plasticity. However, it is now evident that, in developing thalamic and cortical principal- and inter-neurones, an endogenous neurosteroid tone (eg, a …
Conventionally, programmed expression changes to the subtype of synaptic GABA(A) R are primarily implicated in this plasticity …
GABAA Receptor Subtypes Regulate Stress-Induced Colon Inflammation in Mice.
Seifi M, Rodaway S, Rudolph U, Swinny JD. Seifi M, et al. Gastroenterology. 2018 Sep;155(3):852-864.e3. doi: 10.1053/j.gastro.2018.05.033. Epub 2018 May 23. Gastroenterology. 2018. PMID: 29802853 Free article.
We also performed studies of mice with disruption of the GABA(A)R subunit alpha3 gene (Gabra3(-/-) mice). RESULTS: Mice exposed to early-life stress had significantly altered GABA(A)R-mediated colonic contractility and impaired barrier function, and th …
We also performed studies of mice with disruption of the GABA(A)R subunit alpha3 gene (Gabra3(-/-) mice). RESULTS: Mice expose …
Molecular Characterization of GABA-A Receptor Subunit Diversity within Major Peripheral Organs and Their Plasticity in Response to Early Life Psychosocial Stress.
Everington EA, Gibbard AG, Swinny JD, Seifi M. Everington EA, et al. Front Mol Neurosci. 2018 Feb 6;11:18. doi: 10.3389/fnmol.2018.00018. eCollection 2018. Front Mol Neurosci. 2018. PMID: 29467616 Free PMC article.
Additionally, GABA(A)R-modulating drugs are important tools in clinical medicine, although their use is limited by adverse effects. ...This provides a molecular platform for functional analyses of the GABA-GABA(A)R system in health, and in diseases aff …
Additionally, GABA(A)R-modulating drugs are important tools in clinical medicine, although their use is limited by adverse eff …
Developmental and age-dependent plasticity of GABAA receptors in the mouse colon: Implications in colonic motility and inflammation.
Seifi M, Swinny JD. Seifi M, et al. Auton Neurosci. 2019 Nov;221:102579. doi: 10.1016/j.autneu.2019.102579. Epub 2019 Aug 15. Auton Neurosci. 2019. PMID: 31445405
We also show that the highest levels of expression for all GABA(A)R subunits is evident at postnatal day (P) 10 apart from the alpha3 subunit which increased with age. ...Collectively, the data provide the first demonstration of the molecular and functional plastici …
We also show that the highest levels of expression for all GABA(A)R subunits is evident at postnatal day (P) 10 apart from the …
Spatiotemporal Distribution of GABAA Receptor Subunits Within Layer II of Mouse Medial Entorhinal Cortex: Implications for Grid Cell Excitability.
Berggaard N, Seifi M, van der Want JJL, Swinny JD. Berggaard N, et al. Front Neuroanat. 2018 Jun 4;12:46. doi: 10.3389/fnana.2018.00046. eCollection 2018. Front Neuroanat. 2018. PMID: 29915531 Free PMC article.
Thus, the overall aim of this study was to provide a high resolution analysis of the major (alpha and gamma) GABA(A)R subunits expressed in proximity to somato-dendritic PV+ boutons, on RE+ and CB+ cells, using immunohistochemistry, confocal microscopy and quantitat …
Thus, the overall aim of this study was to provide a high resolution analysis of the major (alpha and gamma) GABA(A)R subunits …
Identification of intraneuronal amyloid beta oligomers in locus coeruleus neurons of Alzheimer's patients and their potential impact on inhibitory neurotransmitter receptors and neuronal excitability.
Kelly L, Seifi M, Ma R, Mitchell SJ, Rudolph U, Viola KL, Klein WL, Lambert JJ, Swinny JD. Kelly L, et al. Neuropathol Appl Neurobiol. 2021 Jun;47(4):488-505. doi: 10.1111/nan.12674. Epub 2020 Dec 20. Neuropathol Appl Neurobiol. 2021. PMID: 33119191
Patch clamp electrophysiology recordings revealed that APP-PSEN1 LC neuronal hyperexcitability accompanied this AbetaO expression profile, arising from a diminished inhibitory effect of GABA due to impaired expression and function of the GABA-A receptor (GABA(A) R) …
Patch clamp electrophysiology recordings revealed that APP-PSEN1 LC neuronal hyperexcitability accompanied this AbetaO expression profile, a …