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Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia.
Amatngalim GD, Rodenburg LW, Aalbers BL, Raeven HH, Aarts EM, Sarhane D, Spelier S, Lefferts JW, Silva IA, Nijenhuis W, Vrendenbarg S, Kruisselbrink E, Brunsveld JE, van Drunen CM, Michel S, de Winter-de Groot KM, Heijerman HG, Kapitein LC, Amaral MD, van der Ent CK, Beekman JM. Amatngalim GD, et al. Among authors: aalbers bl. Life Sci Alliance. 2022 Aug 3;5(12):e202101320. doi: 10.26508/lsa.202101320. Life Sci Alliance. 2022. PMID: 35922154 Free PMC article.
CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank.
Geurts MH, de Poel E, Amatngalim GD, Oka R, Meijers FM, Kruisselbrink E, van Mourik P, Berkers G, de Winter-de Groot KM, Michel S, Muilwijk D, Aalbers BL, Mullenders J, Boj SF, Suen SWF, Brunsveld JE, Janssens HM, Mall MA, Graeber SY, van Boxtel R, van der Ent CK, Beekman JM, Clevers H. Geurts MH, et al. Among authors: aalbers bl. Cell Stem Cell. 2020 Apr 2;26(4):503-510.e7. doi: 10.1016/j.stem.2020.01.019. Epub 2020 Feb 20. Cell Stem Cell. 2020. PMID: 32084388 Free article.
Females with cystic fibrosis have a larger decrease in sweat chloride in response to lumacaftor/ivacaftor compared to males.
Aalbers BL, Hofland RW, Bronsveld I, de Winter-de Groot KM, Arets HGM, de Kiviet AC, van Oirschot-van de Ven MMM, Kruijswijk MA, Schotman S, Michel S, van der Ent CK, Heijerman HGM. Aalbers BL, et al. J Cyst Fibros. 2021 Jan;20(1):e7-e11. doi: 10.1016/j.jcf.2020.05.004. Epub 2020 May 21. J Cyst Fibros. 2021. PMID: 32448708 Free article.
Centralized intestinal organoid generation is a feasible and safe approach for personalized medicine as demonstrated in the HIT-CF Europe Organoid Study.
Bierlaagh MC, van Mourik P, Vonk AM, Pott J, Muilwijk D, Berkers G, Aalbers BL, Vleggaar FP, Michel S, Boj SF, Vries RGJ, Beekman JM, van der Ent CK; HIT-CF organoid study group. Bierlaagh MC, et al. Among authors: aalbers bl. J Cyst Fibros. 2024 May 18:S1569-1993(24)00061-4. doi: 10.1016/j.jcf.2024.04.016. Online ahead of print. J Cyst Fibros. 2024. PMID: 38763840 Free article.