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Page 1
ABCA6 Regulates Chondrogenesis and Inhibits Joint Degeneration via Orchestrated Cholesterol Efflux and Cellular Senescence.
Wang Y, Wu Q, You Y, Jiang W, Fu P, Dai K, Sun Y. Wang Y, et al. Adv Sci (Weinh). 2025 Mar;12(10):e2410414. doi: 10.1002/advs.202410414. Epub 2025 Jan 17. Adv Sci (Weinh). 2025. PMID: 39823538 Free PMC article.
Besides, synovial mesenchymal stem cells (SMSCs) are extracted from WT, ABCA6(-/+), and ABCA6(-/-) mice to create chondrogenic organoids in vitro, confirming ABCA6 deficiency can lead to chondrocyte degeneration via modulating cell cycle and activating cellul …
Besides, synovial mesenchymal stem cells (SMSCs) are extracted from WT, ABCA6(-/+), and ABCA6(-/-) mice to create chondrogenic …
ABCA6 affects the malignancy of Ewing sarcoma cells via cholesterol-guided inhibition of the IGF1R/AKT/MDM2 axis.
Pasello M, Giudice AM, Cristalli C, Manara MC, Mancarella C, Parra A, Serra M, Magagnoli G, Cidre-Aranaz F, Grünewald TGP, Bini C, Lollini PL, Longhi A, Donati DM, Scotlandi K. Pasello M, et al. Cell Oncol (Dordr). 2022 Dec;45(6):1237-1251. doi: 10.1007/s13402-022-00713-5. Epub 2022 Sep 23. Cell Oncol (Dordr). 2022. PMID: 36149602 Free PMC article.
Mechanistically, high expression of ABCA6 impaired cell migration and increased cell chemosensitivity by diminishing the intracellular levels of cholesterol and by constitutive IGF1R/AKT/mTOR expression/activation. ...Our findings also support a role of ABCA6 as bio …
Mechanistically, high expression of ABCA6 impaired cell migration and increased cell chemosensitivity by diminishing the intracellula …
Hypercholesterolemia risk associated Abca6 does not regulate lipoprotein metabolism in mice or hamster.
He B, Kang S, Chen Z, Liu X, Wang J, Li X, Liu X, Zheng L, Luo M, Wang Y. He B, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Nov;1866(11):159006. doi: 10.1016/j.bbalip.2021.159006. Epub 2021 Jul 16. Biochim Biophys Acta Mol Cell Biol Lipids. 2021. PMID: 34274505
Rs77542162 is a common missense variant in ABCA6 and is strongly associated with hypercholesterolemia in different populations. ABCA6 is a cholesterol responsive gene and has been suggested to play a role in lipid metabolism. However, whether and how rs77542162 and …
Rs77542162 is a common missense variant in ABCA6 and is strongly associated with hypercholesterolemia in different populations. AB …
Non-synonymous alterations in AKR7A3 and ABCA6 correlate with bleeding in aged patients treated with rivaroxaban.
Zhao M, Zhang Q, Wang X, Zhang Q, Tian C, Li R, Jia X, Gu M, Yang L. Zhao M, et al. Clin Transl Sci. 2022 Apr;15(4):923-929. doi: 10.1111/cts.13205. Epub 2021 Dec 13. Clin Transl Sci. 2022. PMID: 34859601 Free PMC article.
To explore potential drivers of individual differences in adverse reactions induced by rivaroxaban, we performed whole-exome sequencing and found that AKR7A3 rs1738023/rs1738025 and ABCA6 rs7212506 are susceptible sites for rivaroxaban-related bleeding in aged patients tre …
To explore potential drivers of individual differences in adverse reactions induced by rivaroxaban, we performed whole-exome sequencing and …
Correction to: ABCA6 affects the malignancy of Ewing sarcoma cells via cholesterol-guided inhibition of the IGF1R/AKT/MDM2 axis.
Pasello M, Giudice AM, Cristalli C, Manara MC, Mancarella C, Parra A, Serra M, Magagnoli G, Cidre-Aranaz F, Grünewald TGP, Bini C, Lollini PL, Longhi A, Donati DM, Scotlandi K. Pasello M, et al. Cell Oncol (Dordr). 2022 Dec;45(6):1253. doi: 10.1007/s13402-022-00735-z. Cell Oncol (Dordr). 2022. PMID: 36352194 Free PMC article. No abstract available.
ABCA6, a novel a subclass ABC transporter.
Kaminski WE, Wenzel JJ, Piehler A, Langmann T, Schmitz G. Kaminski WE, et al. Biochem Biophys Res Commun. 2001 Aug 3;285(5):1295-301. doi: 10.1006/bbrc.2001.5326. Biochem Biophys Res Commun. 2001. PMID: 11478798
In agreement with the proposed classification, the novel transporter was designated ABCA6. The ABCA6 gene is ubiquitously expressed with highest mRNA levels in liver, lung, heart and brain. ...Based on its structural features and its cholesterol-responsive regulatio …
In agreement with the proposed classification, the novel transporter was designated ABCA6. The ABCA6 gene is ubiquitously expr …
FoxO regulates expression of ABCA6, an intracellular ATP-binding-cassette transporter responsive to cholesterol.
Gai J, Ji M, Shi C, Li W, Chen S, Wang Y, Li H. Gai J, et al. Int J Biochem Cell Biol. 2013 Nov;45(11):2651-9. doi: 10.1016/j.biocel.2013.08.020. Epub 2013 Sep 9. Int J Biochem Cell Biol. 2013. PMID: 24028821
Two functional FoxO-responsive elements were identified in ABCA6 promoter and characterized in detail. ABCA6 mRNA was suppressed by insulin-like growth factor-1 which stimulates the phosphorylation and inactivation of FoxOs while inhibitor of phosphatidylinositol 3- …
Two functional FoxO-responsive elements were identified in ABCA6 promoter and characterized in detail. ABCA6 mRNA was suppress …
The Evolution of the Mammalian ABCA6-like Genes: Analysis of Phylogenetic, Expression, and Population Genetic Data Reveals Complex Evolutionary Histories.
Breuss MW, Mamerto A, Renner T, Waters ER. Breuss MW, et al. Genome Biol Evol. 2020 Nov 3;12(11):2093-2106. doi: 10.1093/gbe/evaa179. Genome Biol Evol. 2020. PMID: 32877505 Free PMC article.
Our analysis finds that ABCA6-like genes, consisting of ABCA6, 8, 9, and 10, are absent from representatives of both monotremes and marsupials and thus the duplications that generated these families most likely occurred at the base of the Eutherian or placental mamm …
Our analysis finds that ABCA6-like genes, consisting of ABCA6, 8, 9, and 10, are absent from representatives of both monotreme …
Genome of The Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels.
van Leeuwen EM, Karssen LC, Deelen J, Isaacs A, Medina-Gomez C, Mbarek H, Kanterakis A, Trompet S, Postmus I, Verweij N, van Enckevort DJ, Huffman JE, White CC, Feitosa MF, Bartz TM, Manichaikul A, Joshi PK, Peloso GM, Deelen P, van Dijk F, Willemsen G, de Geus EJ, Milaneschi Y, Penninx BW, Francioli LC, Menelaou A, Pulit SL, Rivadeneira F, Hofman A, Oostra BA, Franco OH, Mateo Leach I, Beekman M, de Craen AJ, Uh HW, Trochet H, Hocking LJ, Porteous DJ, Sattar N, Packard CJ, Buckley BM, Brody JA, Bis JC, Rotter JI, Mychaleckyj JC, Campbell H, Duan Q, Lange LA, Wilson JF, Hayward C, Polasek O, Vitart V, Rudan I, Wright AF, Rich SS, Psaty BM, Borecki IB, Kearney PM, Stott DJ, Adrienne Cupples L; Genome of The Netherlands Consortium; Jukema JW, van der Harst P, Sijbrands EJ, Hottenga JJ, Uitterlinden AG, Swertz MA, van Ommen GJ, de Bakker PI, Eline Slagboom P, Boomsma DI, Wijmenga C, van Duijn CM. van Leeuwen EM, et al. Nat Commun. 2015 Mar 9;6:6065. doi: 10.1038/ncomms7065. Nat Commun. 2015. PMID: 25751400 Free PMC article.
We report the discovery of five novel associations at four loci (P value <6.61 10(-4)), including a rare missense variant in ABCA6 (rs77542162, p.Cys1359Arg, frequency 0.034), which is predicted to be deleterious. The frequency of this ABCA6 variant is 3.65-fold …
We report the discovery of five novel associations at four loci (P value <6.61 10(-4)), including a rare missense variant in ABCA6 …
Identification of key biomarkers related to fibrocartilage chondrocytes for osteoarthritis based on bulk, single-cell transcriptomic data.
Pan B, Yao P, Ma J, Lin X, Zhou L, Lin C, Zhang Y, Lin B, Lin C. Pan B, et al. Front Immunol. 2024 Nov 21;15:1482361. doi: 10.3389/fimmu.2024.1482361. eCollection 2024. Front Immunol. 2024. PMID: 39640258 Free PMC article.
IHC showed significantly lower protein levels of ABCA5, ABCA6 and SLC7A8 in OA samples than in normal samples. CONCLUSION: This study used a multi-omics approach to identify six FC-related OA biomarkers (BCL6, ABCA5, ABCA6, CITED2, NR1D1, and SLC7A8) and developed a …
IHC showed significantly lower protein levels of ABCA5, ABCA6 and SLC7A8 in OA samples than in normal samples. CONCLUSION: This study …
54 results