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1,071 results

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Page 1
ABCG5/G8: a structural view to pathophysiology of the hepatobiliary cholesterol secretion.
Zein AA, Kaur R, Hussein TOK, Graf GA, Lee JY. Zein AA, et al. Biochem Soc Trans. 2019 Oct 31;47(5):1259-1268. doi: 10.1042/BST20190130. Biochem Soc Trans. 2019. PMID: 31654053 Free PMC article. Review.
The ABCG5/G8 heterodimer is the primary neutral sterol transporter in hepatobiliary and transintestinal cholesterol excretion. ...Over the past decade, several missense variants of ABCG5/G8 have been associated with non-Sitosterolemia lipid phenotypes. In this revie …
The ABCG5/G8 heterodimer is the primary neutral sterol transporter in hepatobiliary and transintestinal cholesterol excretion. ...Ove …
Association of ABCG5 and ABCG8 Transporters with Sitosterolemia.
Bydlowski SP, Levy D. Bydlowski SP, et al. Adv Exp Med Biol. 2024;1440:31-42. doi: 10.1007/978-3-031-43883-7_2. Adv Exp Med Biol. 2024. PMID: 38036873 Review.
It is caused by inactivating mutations in either ABCG5 or ABCG8 subunits, a subfamily-G ATP-binding cassette (ABCG) transporters. ABCG5/G8 encodes a pair of ABC half transporters that form a heterodimer (G5G8). ...Here, we review the biological characteristics and f …
It is caused by inactivating mutations in either ABCG5 or ABCG8 subunits, a subfamily-G ATP-binding cassette (ABCG) transporters. …
ABCG5 and ABCG8: more than a defense against xenosterols.
Patel SB, Graf GA, Temel RE. Patel SB, et al. J Lipid Res. 2018 Jul;59(7):1103-1113. doi: 10.1194/jlr.R084244. Epub 2018 May 4. J Lipid Res. 2018. PMID: 29728459 Free PMC article. Review.
The elucidation of the molecular basis of the rare disease, sitosterolemia, has revolutionized our mechanistic understanding of how dietary sterols are excreted and how cholesterol is eliminated from the body. Two proteins, ABCG5 and ABCG8, encoded by the sitosterolemia lo …
The elucidation of the molecular basis of the rare disease, sitosterolemia, has revolutionized our mechanistic understanding of how dietary …
Picky ABCG5/G8 and promiscuous ABCG2 - a tale of fatty diets and drug toxicity.
Khunweeraphong N, Mitchell-White J, Szöllősi D, Hussein T, Kuchler K, Kerr ID, Stockner T, Lee JY. Khunweeraphong N, et al. FEBS Lett. 2020 Dec;594(23):4035-4058. doi: 10.1002/1873-3468.13938. Epub 2020 Oct 14. FEBS Lett. 2020. PMID: 32978801 Free PMC article. Review.
Structural data on ABCG5/G8 and ABCG2 reveal a unique molecular architecture for subfamily G ATP-binding cassette (ABCG) transporters and disclose putative substrate-binding sites. ...Finally, we elaborate on how ABCG2 and ABCG5/G8 could pave the way for studies on …
Structural data on ABCG5/G8 and ABCG2 reveal a unique molecular architecture for subfamily G ATP-binding cassette (ABCG) transporters …
Recent advances in ABCG5 and ABCG8 variants.
Fong V, Patel SB. Fong V, et al. Curr Opin Lipidol. 2021 Apr 1;32(2):117-122. doi: 10.1097/MOL.0000000000000734. Curr Opin Lipidol. 2021. PMID: 33395105 Free PMC article. Review.
PURPOSE OF REVIEW: In this review, we summarize the genetics and mechanisms of sitosterolemia and sterol trafficking, and provide an update on the understanding of the prevalence of ABCG5 and ABCG8 variants and their role in human disease. RECENT FINDINGS: Defects in AB …
PURPOSE OF REVIEW: In this review, we summarize the genetics and mechanisms of sitosterolemia and sterol trafficking, and provide an update …
ABCG5/ABCG8 in cholesterol excretion and atherosclerosis.
Yu XH, Qian K, Jiang N, Zheng XL, Cayabyab FS, Tang CK. Yu XH, et al. Clin Chim Acta. 2014 Jan 20;428:82-8. doi: 10.1016/j.cca.2013.11.010. Epub 2013 Nov 16. Clin Chim Acta. 2014. PMID: 24252657 Review.
ATP-binding cassette (ABC) transporters G5 (ABCG5) and G8 (ABCG8) form an obligate heterodimer that limits intestinal absorption and facilitates biliary secretion of cholesterol and phytosterols. Consistent with their function, ABCG5 and ABCG8 are located on the api …
ATP-binding cassette (ABC) transporters G5 (ABCG5) and G8 (ABCG8) form an obligate heterodimer that limits intestinal absorption and …
GOLM1 promotes cholesterol gallstone formation via ABCG5-mediated cholesterol efflux in metabolic dysfunction-associated steatohepatitis livers.
Li YT, Shao WQ, Chen ZM, Ma XC, Yi CH, Tao BR, Zhang B, Ma Y, Zhang G, Zhang R, Geng Y, Lin J, Chen JH. Li YT, et al. Clin Mol Hepatol. 2025 Apr;31(2):409-425. doi: 10.3350/cmh.2024.0657. Epub 2024 Dec 10. Clin Mol Hepatol. 2025. PMID: 39657752 Free PMC article.
In vivo and in vitro assays confirmed that GOLM1 facilitated cholesterol efflux through upregulating ATP binding cassette transporter subfamily G member 5 (ABCG5). Mechanistically, GOLM1 translocated into nucleus to promote osteopontin (OPN) transcription, thus stimulating …
In vivo and in vitro assays confirmed that GOLM1 facilitated cholesterol efflux through upregulating ATP binding cassette transporter subfam …
ABCG5 and ABCG8 Are Involved in Vitamin K Transport.
Matsuo M, Ogata Y, Yamanashi Y, Takada T. Matsuo M, et al. Nutrients. 2023 Feb 16;15(4):998. doi: 10.3390/nu15040998. Nutrients. 2023. PMID: 36839356 Free PMC article.
BHK cells expressing ABCG5/ABCG8 were more resistant to vitamin K(3) cytotoxicity than control cells, suggesting that ABCG5/ABCG8 transports vitamin K(3) out of cells. ...To examine the transport of vitamin K(1) by ABCG5/ABCG8, vitamin K(1) levels in the medi …
BHK cells expressing ABCG5/ABCG8 were more resistant to vitamin K(3) cytotoxicity than control cells, suggesting that ABCG5/AB …
Snapshots of ABCG1 and ABCG5/G8: A Sterol's Journey to Cross the Cellular Membranes.
Rezaei F, Farhat D, Gursu G, Samnani S, Lee JY. Rezaei F, et al. Int J Mol Sci. 2022 Dec 28;24(1):484. doi: 10.3390/ijms24010484. Int J Mol Sci. 2022. PMID: 36613930 Free PMC article. Review.
Recent progress in the structural data of ABCG1 and ABCG5/G8 disclose putative sterol binding sites that suggest the possible cholesterol translocation pathway. ...Interestingly, ABCG5/G8 is known to transport cholesterol and phytosterols, whereas ABCG1 seems to exc …
Recent progress in the structural data of ABCG1 and ABCG5/G8 disclose putative sterol binding sites that suggest the possible cholest …
ABCG5 and ABCG8 genetic variants in familial hypercholesterolemia.
Reeskamp LF, Volta A, Zuurbier L, Defesche JC, Hovingh GK, Grefhorst A. Reeskamp LF, et al. J Clin Lipidol. 2020 Mar-Apr;14(2):207-217.e7. doi: 10.1016/j.jacl.2020.01.007. Epub 2020 Jan 29. J Clin Lipidol. 2020. PMID: 32088153
Clinical characteristics of carriers of putative pathogenic variants in ABCG5 and/or ABCG8 were compared with heterozygous carriers of mutations in LDLR. Furthermore, we assessed the segregation of one ABCG5 and two ABCG8 variants with plasma lipid and sterol levels …
Clinical characteristics of carriers of putative pathogenic variants in ABCG5 and/or ABCG8 were compared with heterozygous carriers o …
1,071 results