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ABT1 modifies SMARD1 pathology via interactions with IGHMBP2 and stimulation of ATPase and helicase activity.
Vadla GP, Ricardez Hernandez SM, Mao J, Garro-Kacher MO, Lorson ZC, Rice RP, Hansen SA, Lorson CL, Singh K, Lorson MA. Vadla GP, et al. JCI Insight. 2023 Jan 24;8(2):e164608. doi: 10.1172/jci.insight.164608. JCI Insight. 2023. PMID: 36480289 Free PMC article.
This study examines activator of basal transcription 1 (ABT1), a modifier of SMARD1-nmd disease pathology. Microscale thermophoresis and dynamic light scattering demonstrate that IGHMBP2 and ABT1 proteins directly interact with high affinity. ...The IGHMBP2/ABT1 …
This study examines activator of basal transcription 1 (ABT1), a modifier of SMARD1-nmd disease pathology. Microscale thermophoresis …
E3 ligase ATL5 positively regulates seed longevity by mediating the degradation of ABT1 in Arabidopsis.
He W, Wang R, Zhang Q, Fan M, Lyu Y, Chen S, Chen D, Chen X. He W, et al. New Phytol. 2023 Sep;239(5):1754-1770. doi: 10.1111/nph.19080. Epub 2023 Jun 20. New Phytol. 2023. PMID: 37337822 Free article.
In vitro and in vivo assays showed that ATL5 functions as an E3 ligase and mediates the polyubiquitination and degradation of ABT1. Disruption of ATL5 diminished the degradation of translated ABT1, and the degradation could be induced by seed ageing and occurred in …
In vitro and in vivo assays showed that ATL5 functions as an E3 ligase and mediates the polyubiquitination and degradation of ABT1. D …
Activation tagging identifies WRKY14 as a repressor of plant thermomorphogenesis in Arabidopsis.
Qin W, Wang N, Yin Q, Li H, Wu AM, Qin G. Qin W, et al. Mol Plant. 2022 Nov 7;15(11):1725-1743. doi: 10.1016/j.molp.2022.09.018. Epub 2022 Sep 24. Mol Plant. 2022. PMID: 36155833 Free article.
In this study, we identified ABNORMAL THERMOMORPHOGENESIS 1 (ABT1) as an important negative regulator of PIF4 and plant thermomorphogenesis. Overexpression of ABT1 in the activation tagging mutant abt1-D caused shorter hypocotyls and petioles under moderately …
In this study, we identified ABNORMAL THERMOMORPHOGENESIS 1 (ABT1) as an important negative regulator of PIF4 and plant thermomorphog …
ABT1-associated protein (ABTAP), a novel nuclear protein conserved from yeast to mammals, represses transcriptional activation by ABT1.
Oda T, Fukuda A, Hagiwara H, Masuho Y, Muramatsu MA, Hisatake K, Yamashita T. Oda T, et al. J Cell Biochem. 2004 Nov 1;93(4):788-806. doi: 10.1002/jcb.20114. J Cell Biochem. 2004. PMID: 15660422
ABTAP formed a complex with ABT1 and suppressed the ABT1-induced activation of Pol II-directed transcription in mammalian cells. Furthermore, ABTAP directly bound to ABT1, disrupted the interaction between ABT1 and TBP, and suppressed the ABT1-i …
ABTAP formed a complex with ABT1 and suppressed the ABT1-induced activation of Pol II-directed transcription in mammalian cell …
The contribution and therapeutic implications of IGHMBP2 mutations on IGHMBP2 biochemical activity and ABT1 association.
Vadla GP, Singh K, Lorson CL, Lorson MA. Vadla GP, et al. Biochim Biophys Acta Mol Basis Dis. 2024 Apr;1870(4):167091. doi: 10.1016/j.bbadis.2024.167091. Epub 2024 Feb 24. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 38403020 Free PMC article.
We show that IGHMBP2 mutations that alter the association with activator of basal transcription (ABT1) impact the ATPase and helicase activities of IGHMBP2 and the association with the 47S pre-rRNA 5' external transcribed spacer. ...The H924Y mutation alters IGHMBP2 activi …
We show that IGHMBP2 mutations that alter the association with activator of basal transcription (ABT1) impact the ATPase and helicase …
Mouse Dfa is a repressor of TATA-box promoters and interacts with the Abt1 activator of basal transcription.
Brower CS, Veiga L, Jones RH, Varshavsky A. Brower CS, et al. J Biol Chem. 2010 May 28;285(22):17218-34. doi: 10.1074/jbc.M110.118638. Epub 2010 Mar 31. J Biol Chem. 2010. PMID: 20356838 Free PMC article.
Furthermore, Dfa(A) was present in the interchromatin granule clusters and was also found to bind to the Ggnbp1 gametogenetin-binding protein-1 and to the Abt1 activator of basal transcription that interacts with the TATA-binding protein. Given these results, RNA interfere …
Furthermore, Dfa(A) was present in the interchromatin granule clusters and was also found to bind to the Ggnbp1 gametogenetin-binding protei …
Recurrent Duplication, Testis-Biased Expression, and Functional Diversification of Esf2/ABT1 Family Genes in Drosophila.
Davydova ED, Kotov AA, Chernizova AV, Yakovleva EY, Olenina LV. Davydova ED, et al. Insects. 2025 Sep 11;16(9):956. doi: 10.3390/insects16090956. Insects. 2025. PMID: 41009135 Free PMC article.
In three species of the suzukii subgroup, Esf2/ABP1 genes evolved with domain diversification: in addition to RNA-binding ABT1-like domain preservation, all homologous proteins acquired expanded intrinsically disordered regions. ...
In three species of the suzukii subgroup, Esf2/ABP1 genes evolved with domain diversification: in addition to RNA-binding ABT1-like d …
Isolation and characterization of a novel phage AbT1 and evaluating its anti-biofilm activity and antibiotic synergy.
Li X, Liu J, Li H, Zhang W, Wei H, Song S, Chen X. Li X, et al. Mol Biol Rep. 2026 Feb 26;53(1):435. doi: 10.1007/s11033-026-11608-1. Mol Biol Rep. 2026. PMID: 41746453
This approach harnesses the natural predatory ability of bacteriophages to combat bacterial infections. METHODS AND RESULTS: A novel phage, AbT1, specific for A. baumannii, was isolated and comprehensively characterized. Under testing conditions, the phage AbT1 demo …
This approach harnesses the natural predatory ability of bacteriophages to combat bacterial infections. METHODS AND RESULTS: A novel phage, …
44 results