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Page 1
Ketone body β-hydroxybutyrate-mediated histone β-hydroxybutyrylation upregulates lipolysis and attenuates metabolic syndrome.
Aryal S, Mell B, Manandhar I, Yeoh BS, Mei X, Akinola OM, Ahlidja W, Joe B. Aryal S, et al. Am J Physiol Cell Physiol. 2025 Sep 1;329(3):C726-C743. doi: 10.1152/ajpcell.00453.2025. Epub 2025 Jul 28. Am J Physiol Cell Physiol. 2025. PMID: 40720185 Free PMC article.
The mechanism was traced to a key modification of histone-3 lysine 9 via beta-hydroxybutyrylation, which remodeled the epitranscriptome to increase the accessibility of chromatin to transcriptionally upregulate key lipolytic genes, Hmgcs2, Cyp2d4, Cyp2e1, and Acaa1b. Since …
The mechanism was traced to a key modification of histone-3 lysine 9 via beta-hydroxybutyrylation, which remodeled the epitranscriptome to i …
Integrated single-cell transcriptomics and proteomics elucidate the molecular mechanisms and detoxification strategy of rifampicin-induced hepatotoxicity.
Chen J, Zhang Q, Huang J, He H, Bai Y, An Y, Hao M, Zhao W, Li W, Feng S, Yang S, Liao J, Wong YK, Dai L, Du Q, Luo P, Wang J. Chen J, et al. Int J Biol Sci. 2026 Jan 1;22(1):481-499. doi: 10.7150/ijbs.109757. eCollection 2026. Int J Biol Sci. 2026. PMID: 41362738 Free PMC article.
Moreover, decreased mTOR expression and increased expression of fatty acid oxidation-related genes including Acox1 and Acaa1b suggested an enhanced oxidative metabolism. Recruitment of macrophages further exacerbated hepatocyte damage. ...
Moreover, decreased mTOR expression and increased expression of fatty acid oxidation-related genes including Acox1 and Acaa1b suggest …
NIEHS Report on the In Vivo Repeat Dose Biological Potency Study of Perfluorohexanesulfonamide (CASRN 41997-13-1) in Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats (Gavage Studies): NIEHS Report 10 [Internet].
Auerbach SS, Ballin JD, Blake JC, Browning DB, Collins BJ, Cora MC, Fernando RA, Fostel JM, Liu YF, Luh J, Machesky NJ, Prince LM, Roberts GK, Shipkowski KA, Silinski MAR, Skowronek AJ, Sparrow BR, Toy H, Waidyanatha S, Watson ATD. Auerbach SS, et al. Research Triangle Park (NC): National Institute of Environmental Health Sciences; 2023 Mar. Research Triangle Park (NC): National Institute of Environmental Health Sciences; 2023 Mar. PMID: 37018438 Free Books & Documents. Review.
The most sensitive upregulated genes in male rats with reliable BMD estimates included Gsta2, Gsta5, Crot, Slc27a2, Acaa1a, and Acaa1b with BMDs (BMD(L)s) of 5.725 (1.686), 5.725 (1.686), 7.423 (5.757), 7.622 (5.499), 8.417 (7.129), and 8.417 (7.129) mg/kg, respectively. . …
The most sensitive upregulated genes in male rats with reliable BMD estimates included Gsta2, Gsta5, Crot, Slc27a2, Acaa1a, and Acaa1b …
Gestational GenX and PFOA exposures induce hepatotoxicity, metabolic pathway, and microbiome shifts in weanling mice.
Zhang QY, Xu LL, Zhong MT, Chen YK, Lai MQ, Wang Q, Xie XL. Zhang QY, et al. Sci Total Environ. 2024 Jan 10;907:168059. doi: 10.1016/j.scitotenv.2023.168059. Epub 2023 Oct 24. Sci Total Environ. 2024. PMID: 37884144
Moreover, overexpression of CYP4A14, Sult2a1, Cpt1b, Acaa1b, Igfbp1, Irs-2 and decreased expression of Gys2 were observed in livers of GenX exposed pups, supporting the hypothesis that there was metabolic disruption. ...
Moreover, overexpression of CYP4A14, Sult2a1, Cpt1b, Acaa1b, Igfbp1, Irs-2 and decreased expression of Gys2 were observed in livers o …
Integration of metabolomics and transcriptomics to reveal the mechanism of Gerberae piloselloidis herba in alleviating bronchial asthma.
Liu C, Fu C, Lu Y, Sun J, Liu T, Wang Y, Wang A, Huang Y, Li Y. Liu C, et al. J Ethnopharmacol. 2024 May 10;325:117852. doi: 10.1016/j.jep.2024.117852. Epub 2024 Feb 1. J Ethnopharmacol. 2024. PMID: 38307356
Integration analysis of metabolomics and transcriptomics revealed that GPH might regulate the PPAR signaling pathway, thus affecting the expression of key gene targets such as Cyp4a12a, Cyp4a12b, Adh7, Acaa1b and Gpat2; controlling fatty acid degradation, unsaturated fatty …
Integration analysis of metabolomics and transcriptomics revealed that GPH might regulate the PPAR signaling pathway, thus affecting the exp …
NIEHS Report on the In Vivo Repeat Dose Biological Potency Study of 6:1 Fluorotelomer Alcohol (CASRN 375-82-6) in Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats (Gavage Studies): NIEHS Report 07 [Internet].
Auerbach SS, Aillon KL, Ballin JD, Collins BJ, Cora MC, Duncan NS, Fostel JM, Liu YF, Luh J, Machesky NJ, Pickett SJ, Roberts GK, Shipkowski KA, Skowronek AJ, Smith L, Sparrow BR, Toy H, Waidyanatha S, Watson ATD. Auerbach SS, et al. Research Triangle Park (NC): National Institute of Environmental Health Sciences; 2023 Mar. Research Triangle Park (NC): National Institute of Environmental Health Sciences; 2023 Mar. PMID: 37018435 Free Books & Documents. Review.
The most sensitive upregulated genes in male rats with reliable BMD estimates included Acot2, Eci1, Loc100911558/Spink1l, Spink1, Ehhadh, Crot, Acaa1a, and Acaa1b with BMDs (BMD(L)s) of 1.012 (0.809), 1.013 (0.769), 1.270 (0.542), 1.270 (0.542), 1.280 (1.047), 1.411 (1.092 …
The most sensitive upregulated genes in male rats with reliable BMD estimates included Acot2, Eci1, Loc100911558/Spink1l, Spink1, Ehhadh, Cr …
Aqueous Polygalae Radix extract (PRE) prolongs the lifespan of C. elegans and alleviates D-galactose-induced oxidative stress in the mouse liver and brain by modulating PPARγ/MAPK.
Zhang J, Zheng W, Zhou Z, An Y, Zheng H, Zhang Y, Wei Y, Zhang Q, Zheng J, Wang F. Zhang J, et al. J Ethnopharmacol. 2025 May 28;348:119878. doi: 10.1016/j.jep.2025.119878. Epub 2025 Apr 24. J Ethnopharmacol. 2025. PMID: 40287113 Free article.
The RNA-seq results suggested that PRE might be related to PPARgamma/MAPK, and the subsequent RT-qPCR and cell transfection results indicated that PRE decreased oxidative stress by downregulating the mRNA expression of the Fabp1, Acaa1b, Hmgcs1, Map3K5, and Rac2 genes. The …
The RNA-seq results suggested that PRE might be related to PPARgamma/MAPK, and the subsequent RT-qPCR and cell transfection results indicate …
[Preliminary study on differentially expressed proteins in a mouse model of secondary alveolar echinococcosis based on data independent acquisition proteomics].
Si XM, Ma JY, Zhang XF, Wang H, Sun X, Ma X, Wang W, Liu YF, Liu J, Guo S, Han DH, Han S. Si XM, et al. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2022 Feb 22;34(1):52-58. doi: 10.16250/j.32.1374.2021221. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2022. PMID: 35266357 Chinese.
Several differentially expressed proteins that may contribute to the pathogenesis of alveolar echinococcosis were identified in these two pathways, including fatty acid binding protein 1 (Fabp1), Acyl-CoA synthetase long chain family member 1 (Acsl1), Acyl-CoA oxidase 1 (Acox1), …
Several differentially expressed proteins that may contribute to the pathogenesis of alveolar echinococcosis were identified in these two pa …
A Novel Camel Milk-Derived Peptide LLPK Improves Glucose-Lipid Metabolism in db/db Mice via PPAR Signaling Pathway.
Han B, Ye Y, Zhang C, Zhang L, Zhou P. Han B, et al. Nutrients. 2025 May 16;17(10):1693. doi: 10.3390/nu17101693. Nutrients. 2025. PMID: 40431433 Free PMC article.
Hepatic proteomics indicated that LLPK improved glucose and lipid metabolism via the PPAR signaling pathway, where the key targets were Scd1, Acox1, Acaa1b, Slc27a1, Acsl1, and Ehhadh. Conclusions: In summary, this study provided new insights into the anti-diabetic mechani …
Hepatic proteomics indicated that LLPK improved glucose and lipid metabolism via the PPAR signaling pathway, where the key targets were Scd1 …
Functional metabolomics revealed functional metabolic-characteristics of chronic hepatitis that is significantly differentiated from acute hepatitis in mice.
Wang T, Hu L, Lu J, Xiao M, Liu J, Xia H, Lu H. Wang T, et al. Pharmacol Res. 2022 Jun;180:106248. doi: 10.1016/j.phrs.2022.106248. Epub 2022 May 7. Pharmacol Res. 2022. PMID: 35537579
Such metabolic discovery on hepatitis was validated by the functional annotation of metabolic genes, as the decreased expressions of Slc27a2, Acaa1a and Acaa1b mostly account for the dysregulation of purine degradation with AH, then the lowered expressions of Cyp2e1, Cat, …
Such metabolic discovery on hepatitis was validated by the functional annotation of metabolic genes, as the decreased expressions of Slc27a2 …
19 results