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Page 1
ADAM23 is a negative regulator of K(v)1.1/K(v)1.4 potassium currents.
Lancaster E, Burnor E, Zhang J, Lancaster E. Lancaster E, et al. Neurosci Lett. 2019 Jun 21;704:159-163. doi: 10.1016/j.neulet.2019.04.012. Epub 2019 Apr 6. Neurosci Lett. 2019. PMID: 30965109
Background ADAM22 and ADAM23 are transmembrane proteins that bind the secreted synaptic protein LGI1 and associate with K(v)1.1/K(v)1.4 potassium channels. ...Methods Cultured cells were transfected to express ADAM22, ADAM23, and K(v)1.1/K(v)1.4. Voltage-gated potas …
Background ADAM22 and ADAM23 are transmembrane proteins that bind the secreted synaptic protein LGI1 and associate with K(v)1.1/K(v)1 …
LGI3/2-ADAM23 interactions cluster Kv1 channels in myelinated axons to regulate refractory period.
Kozar-Gillan N, Velichkova A, Kanatouris G, Eshed-Eisenbach Y, Steel G, Jaegle M, Aunin E, Peles E, Torsney C, Meijer DN. Kozar-Gillan N, et al. J Cell Biol. 2023 Apr 3;222(4):e202211031. doi: 10.1083/jcb.202211031. Epub 2023 Feb 24. J Cell Biol. 2023. PMID: 36828548 Free PMC article.
However, the mechanisms that control the clustering of Kv1 channels, as well as their function at this site, are still poorly understood. Here we demonstrate that axonal ADAM23 is essential for both the accumulation and stability of juxtaparanodal Kv1 complexes. The functi …
However, the mechanisms that control the clustering of Kv1 channels, as well as their function at this site, are still poorly understood. He …
Endocytosis of the non-catalytic ADAM23: Recycling and long half-life properties.
Souza ILM, Oliveira NH, Huamaní PAM, Martin AS, Borgonovo ZLM, Nakao LS, Zanata SM. Souza ILM, et al. Exp Cell Res. 2021 Jan 15;398(2):112415. doi: 10.1016/j.yexcr.2020.112415. Epub 2020 Dec 6. Exp Cell Res. 2021. PMID: 33296662
Also, ADAM23 has been linked to human pathological conditions, such as epilepsy, cancer metastasis and cardiomyopathy. ...Our findings suggest that regulation of ADAM23 endocytosis/stability could be exploited therapeutically in diseases in which ADAM23 is di …
Also, ADAM23 has been linked to human pathological conditions, such as epilepsy, cancer metastasis and cardiomyopathy. ...Our finding …
ADAM23 in Cardiomyocyte Inhibits Cardiac Hypertrophy by Targeting FAK - AKT Signaling.
Xiang M, Luo H, Wu J, Ren L, Ding X, Wu C, Chen J, Chen S, Zhang H, Yu L, Zou Y, Xu H, Ye P, Chen M, Xia J. Xiang M, et al. J Am Heart Assoc. 2018 Sep 18;7(18):e008604. doi: 10.1161/JAHA.118.008604. J Am Heart Assoc. 2018. PMID: 30371220 Free PMC article.
Background Cardiac hypertrophy has been recognized as an important independent risk factor for the development of heart failure and increases the risk of cardiac morbidity and mortality. A disintegrin and metalloprotease 23 (ADAM23), a member of ADAM family, is involved in …
Background Cardiac hypertrophy has been recognized as an important independent risk factor for the development of heart failure and increase …
Identification of ADAM23 as a Potential Signature for Psoriasis Using Integrative Machine-Learning and Experimental Verification.
Yao P, Jia Y, Kan X, Chen J, Xu J, Xu H, Shao S, Ni B, Tang J. Yao P, et al. Int J Gen Med. 2023 Dec 22;16:6051-6064. doi: 10.2147/IJGM.S441262. eCollection 2023. Int J Gen Med. 2023. PMID: 38148887 Free PMC article.
Four machine learning strategies and single-cell RNA sequencing analysis showed that ADAM23, a disintegrin and metalloprotease, may be a unique, critical biomarker with high diagnostic accuracy for psoriasis. ...CONCLUSION: ADAM23 may be a potential biomarker in the …
Four machine learning strategies and single-cell RNA sequencing analysis showed that ADAM23, a disintegrin and metalloprotease, may b …
ADAM23 is a common risk gene for canine idiopathic epilepsy.
Koskinen LL, Seppälä EH, Weissl J, Jokinen TS, Viitmaa R, Hänninen RL, Quignon P, Fischer A, André C, Lohi H. Koskinen LL, et al. BMC Genet. 2017 Jan 31;18(1):8. doi: 10.1186/s12863-017-0478-6. BMC Genet. 2017. PMID: 28143391 Free PMC article.
Genetic association has been reported only with ADAM23 on CFA 37 in few breeds. To identify novel epilepsy genes, we performed genome-wide association (GWA) analyses in four new breeds, and investigated the association of the previously reported ADAM23 haplotype wit …
Genetic association has been reported only with ADAM23 on CFA 37 in few breeds. To identify novel epilepsy genes, we performed genome …
ADAM23 promotes neuronal differentiation of human neural progenitor cells.
Markus-Koch A, Schmitt O, Seemann S, Lukas J, Koczan D, Ernst M, Fuellen G, Wree A, Rolfs A, Luo J. Markus-Koch A, et al. Cell Mol Biol Lett. 2017 Aug 18;22:16. doi: 10.1186/s11658-017-0045-1. eCollection 2017. Cell Mol Biol Lett. 2017. PMID: 28828010 Free PMC article.
BACKGROUND: ADAM23 is widely expressed in the embryonic central nervous system and plays an important role in tissue formation. ...RNA microarray analysis revealed mechanistic insights into genes and pathways that may become involved in multiple cellular processes upon up- …
BACKGROUND: ADAM23 is widely expressed in the embryonic central nervous system and plays an important role in tissue formation. ...RN …
Gene methylation in gastric cancer.
Qu Y, Dang S, Hou P. Qu Y, et al. Clin Chim Acta. 2013 Sep 23;424:53-65. doi: 10.1016/j.cca.2013.05.002. Epub 2013 May 10. Clin Chim Acta. 2013. PMID: 23669186 Free article. Review.
Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity.
Miyazaki Y, Otsuka T, Yamagata Y, Endo T, Sanbo M, Sano H, Kobayashi K, Inahashi H, Kornau HC, Schmitz D, Prüss H, Meijer D, Hirabayashi M, Fukata Y, Fukata M. Miyazaki Y, et al. Cell Rep. 2024 Jan 23;43(1):113634. doi: 10.1016/j.celrep.2023.113634. Epub 2024 Jan 8. Cell Rep. 2024. PMID: 38194969 Free PMC article.
Proteomic analysis using epitope-tagged Lgi3 knockin mice shows that LGI3 uses ADAM23 as a receptor and selectively co-assembles with Kv1 channels. A lack of Lgi3 in mice disrupts juxtaparanodal clustering of ADAM23 and Kv1 channels and suppresses Kv1-channel-mediat …
Proteomic analysis using epitope-tagged Lgi3 knockin mice shows that LGI3 uses ADAM23 as a receptor and selectively co-assembles with …
ADAM23 is downregulated in side population and suppresses lung metastasis of lung carcinoma cells.
Ota M, Mochizuki S, Shimoda M, Abe H, Miyamae Y, Ishii K, Kimura H, Okada Y. Ota M, et al. Cancer Sci. 2016 Apr;107(4):433-43. doi: 10.1111/cas.12895. Epub 2016 Mar 16. Cancer Sci. 2016. PMID: 26800504 Free PMC article.
A similar result on the ADAM23 expression was obtained with another cell line, Calu-3 cells. Overexpression of ADAM23 inhibited colony formation, cell adhesion and migration, and knockdown of ADAM23 by shRNA showed the reverse effects. ADAM23-mediated …
A similar result on the ADAM23 expression was obtained with another cell line, Calu-3 cells. Overexpression of ADAM23 inhibite …
123 results