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Adamtsl3 mediates DCC signaling to selectively promote GABAergic synapse function.
Cramer TML, Pinan-Lucarre B, Cavaccini A, Damilou A, Tsai YC, Bhat MA, Panzanelli P, Rama N, Mehlen P, Benke D, Karayannis T, Bessereau JL, Tyagarajan SK. Cramer TML, et al. Cell Rep. 2023 Aug 29;42(8):112947. doi: 10.1016/j.celrep.2023.112947. Epub 2023 Aug 10. Cell Rep. 2023. PMID: 37572323 Free article.
We demonstrate that early post-natal deletion of Adamtsl3 in neurons impairs DCC protein expression, causing reduced density of both glutamatergic and GABAergic synapses. ...The Adamtsl3-DCC signaling unit is further essential for activity-dependent adaptations at G …
We demonstrate that early post-natal deletion of Adamtsl3 in neurons impairs DCC protein expression, causing reduced density of both …
ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFbeta signalling after pressure overload.
Rypdal KB, Olav Melleby A, Robinson EL, Li J, Palmero S, Seifert DE, Martin D, Clark C, López B, Andreassen K, Dahl CP, Sjaastad I, Tønnessen T, Stokke MK, Louch WE, González A, Heymans S, Christensen G, Apte SS, Lunde IG. Rypdal KB, et al. Commun Biol. 2022 Dec 20;5(1):1392. doi: 10.1038/s42003-022-04361-1. Commun Biol. 2022. PMID: 36539599 Free PMC article.
Further, ADAMTSL3 overexpression in cultured CFBs inhibits TGFbeta signalling, myofibroblast differentiation and collagen synthesis, suggesting a cardioprotective role for ADAMTSL3 by regulating TGFbeta activity and CFB phenotype. These results warrant future invest …
Further, ADAMTSL3 overexpression in cultured CFBs inhibits TGFbeta signalling, myofibroblast differentiation and collagen synthesis, …
Differential Expressions of ADAM28 and ADAMTSL3 in Gingival Tissue of Patients with Periodontitis.
Zhu JJ, Zhong ZH. Zhu JJ, et al. Tohoku J Exp Med. 2023 May 26;260(2):109-117. doi: 10.1620/tjem.2023.J021. Epub 2023 Mar 16. Tohoku J Exp Med. 2023. PMID: 36927684 Free article.
There was one up-regulated mRNA with hypo-methylated gene [ADAM28 (a disintegrin and metalloproteinase 28)] and one down-regulated mRNA with hyper-methylated gene [ADAMTSL3 (a disintegrin-like and metalloprotease domain with thrombospondin type I motifs-like-3)] after inte …
There was one up-regulated mRNA with hypo-methylated gene [ADAM28 (a disintegrin and metalloproteinase 28)] and one down-regulated mRNA with …
ADAMTSL3/punctin-2, a gene frequently mutated in colorectal tumors, is widely expressed in normal and malignant epithelial cells, vascular endothelial cells and other cell types, and its mRNA is reduced in colon cancer.
Koo BH, Hurskainen T, Mielke K, Aung PP, Casey G, Autio-Harmainen H, Apte SS. Koo BH, et al. Int J Cancer. 2007 Oct 15;121(8):1710-6. doi: 10.1002/ijc.22882. Int J Cancer. 2007. PMID: 17597111
ADAMTSL3/punctin-2 is a secreted glycoprotein that resembles the ADAMTS proteases. Recently, identification of frequent ADAMTSL3 mutations in colorectal cancer suggested it might have a regulatory role in cellular homeostasis in colorectal epithelium or in pathways …
ADAMTSL3/punctin-2 is a secreted glycoprotein that resembles the ADAMTS proteases. Recently, identification of frequent ADAMTSL3 …
ADAMTSL3 as a candidate gene for schizophrenia: gene sequencing and ultra-high density association analysis by imputation.
Dow DJ, Huxley-Jones J, Hall JM, Francks C, Maycox PR, Kew JN, Gloger IS, Mehta NA, Kelly FM, Muglia P, Breen G, Jugurnauth S, Pederoso I, St Clair D, Rujescu D, Barnes MR. Dow DJ, et al. Schizophr Res. 2011 Apr;127(1-3):28-34. doi: 10.1016/j.schres.2010.12.009. Epub 2011 Jan 15. Schizophr Res. 2011. PMID: 21239144
To review all variants that could potentially cause the association, and to identify additional possible pathogenic rare variants, we sequenced ADAMTSL3 in 92 schizophrenics. A total of 71 ADAMTSL3 variants were identified by sequencing, many were also seen in the 1 …
To review all variants that could potentially cause the association, and to identify additional possible pathogenic rare variants, we sequen …
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
Zillikens MC, Demissie S, Hsu YH, Yerges-Armstrong LM, Chou WC, Stolk L, Livshits G, Broer L, Johnson T, Koller DL, Kutalik Z, Luan J, Malkin I, Ried JS, Smith AV, Thorleifsson G, Vandenput L, Hua Zhao J, Zhang W, Aghdassi A, Åkesson K, Amin N, Baier LJ, Barroso I, Bennett DA, Bertram L, Biffar R, Bochud M, Boehnke M, Borecki IB, Buchman AS, Byberg L, Campbell H, Campos Obanda N, Cauley JA, Cawthon PM, Cederberg H, Chen Z, Cho NH, Jin Choi H, Claussnitzer M, Collins F, Cummings SR, De Jager PL, Demuth I, Dhonukshe-Rutten RAM, Diatchenko L, Eiriksdottir G, Enneman AW, Erdos M, Eriksson JG, Eriksson J, Estrada K, Evans DS, Feitosa MF, Fu M, Garcia M, Gieger C, Girke T, Glazer NL, Grallert H, Grewal J, Han BG, Hanson RL, Hayward C, Hofman A, Hoffman EP, Homuth G, Hsueh WC, Hubal MJ, Hubbard A, Huffman KM, Husted LB, Illig T, Ingelsson E, Ittermann T, Jansson JO, Jordan JM, Jula A, Karlsson M, Khaw KT, Kilpeläinen TO, Klopp N, Kloth JSL, Koistinen HA, Kraus WE, Kritchevsky S, Kuulasmaa T, Kuusisto J, Laakso M, Lahti J, Lang T, Langdahl BL, Launer LJ, Lee JY, Lerch MM, Lewis JR, Lind L, Lindgren C, Liu Y, Liu T, Liu Y, Ljunggren Ö, Lorentzon M, Luben RN, Maixner W, McGuigan FE, Medina-… See abstract for full author list ➔ Zillikens MC, et al. Nat Commun. 2017 Jul 19;8(1):80. doi: 10.1038/s41467-017-00031-7. Nat Commun. 2017. PMID: 28724990 Free PMC article.
Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/near HSD17 …
Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of Europ …
Genome-wide CRISPR knockout screens identify ADAMTSL3 and PTEN genes as suppressors of HCC proliferation and metastasis, respectively.
Zhou X, Li R, Jing R, Zuo B, Zheng Q. Zhou X, et al. J Cancer Res Clin Oncol. 2020 Jun;146(6):1509-1521. doi: 10.1007/s00432-020-03207-9. Epub 2020 Apr 7. J Cancer Res Clin Oncol. 2020. PMID: 32266537
Downregulation of ADAMTSL3 and PTEN displayed poor overall survival (OS) and predicted poor relapse-free survival (RFS), further supporting their tumour-suppressive roles. Moreover, knocking out either the ADAMTSL3 or PTEN genes promoted either the proliferation or …
Downregulation of ADAMTSL3 and PTEN displayed poor overall survival (OS) and predicted poor relapse-free survival (RFS), further supp …
Molecular characterization, expression pattern, polymorphism and association analysis of bovine ADAMTSL3 gene.
Liu Y, Zan L, Zhao S, Xin Y, Jiao Y, Li K. Liu Y, et al. Mol Biol Rep. 2012 Feb;39(2):1551-60. doi: 10.1007/s11033-011-0894-z. Epub 2011 May 24. Mol Biol Rep. 2012. PMID: 21607618
A disintegrin-like and metalloprotease domain with thrombospondin type I motifs-like 3 (ADAMTSL3) is an important candidate gene for body measurement traits through marker-assisted selection (MAS). ...Our genomic structural analysis showed that bovine ADAMTSL3 share …
A disintegrin-like and metalloprotease domain with thrombospondin type I motifs-like 3 (ADAMTSL3) is an important candidate gene for …
Resectable Non-Small Cell Lung Cancer Heterogeneity and Recurrence Assessed by Tissue Next-Generation Sequencing Genotyping and Circulating Tumor Cell EZH2 Characterization.
Garcia-Diaz A, Moyano-Rodríguez MJ, Garrido-Navas MDC, de Miguel-Perez D, Expósito-Hernández J, Alcázar-Navarrete B, Ortuño F, Landeira D, Romero PJ, Garcia-Moreno A, Lorente JA, Lopez-Hidalgo J, Bayarri-Lara C, Serrano MJ. Garcia-Diaz A, et al. Arch Bronconeumol. 2025 Mar;61(3):156-165. doi: 10.1016/j.arbres.2024.08.006. Epub 2024 Oct 4. Arch Bronconeumol. 2025. PMID: 39414465 English, Spanish.
Pair of genes that had mutually exclusive mutations was TP53-RIN3, and pairs of genes with co-occurring mutations were CD163-TLR4, FGF10-FOXP2, ADAMTSL3-FLT1, ADAMTSL3-MUC5AC and MUC5AC-NLRP3. CTCs decreased significantly between the two time points CTC1 and CTC2 (p …
Pair of genes that had mutually exclusive mutations was TP53-RIN3, and pairs of genes with co-occurring mutations were CD163-TLR4, FGF10-FOX …
Single-nucleus multi-omics analyses reveal cellular and molecular innovations in the anterior cingulate cortex during primate evolution.
Yuan J, Dong K, Wu H, Zeng X, Liu X, Liu Y, Dai J, Yin J, Chen Y, Guo Y, Luo W, Liu N, Sun Y, Zhang S, Su B. Yuan J, et al. Cell Genom. 2024 Dec 11;4(12):100703. doi: 10.1016/j.xgen.2024.100703. Epub 2024 Dec 3. Cell Genom. 2024. PMID: 39631404 Free PMC article.
Our in vitro and in vivo experiments identified a group of primate-shared and human-specific VEN marker genes, such as PCSK6, ADAMTSL3, and CDHR3, potentially contributing to VEN morphogenesis. We demonstrated that the human-specific sequence changes account for the cellul …
Our in vitro and in vivo experiments identified a group of primate-shared and human-specific VEN marker genes, such as PCSK6, ADAMTSL3 …
42 results