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49 results

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ADCY4 promotes brain metastasis in small cell lung cancer and is associated with energy metabolism.
Sun Y, Chen Y, Zhang X, Yi D, Kong F, Zhao L, Liao D, Chen L, Ma Q, Wang Z. Sun Y, et al. Heliyon. 2024 Mar 28;10(7):e28162. doi: 10.1016/j.heliyon.2024.e28162. eCollection 2024 Apr 15. Heliyon. 2024. PMID: 38596032 Free PMC article.
By comparing the significantly differentially expressed genes present in BMs samples, we identified ADCY4 as a target for further study. Expression of ADCY4 was used to cluster mfuzz expression pattern, and 28 hub genes for functional enrichment. ...PCR showed that …
By comparing the significantly differentially expressed genes present in BMs samples, we identified ADCY4 as a target for further stu …
Epigenetic identification of ADCY4 as a biomarker for breast cancer: an integrated analysis of adenylate cyclases.
Fan Y, Mu J, Huang M, Imani S, Wang Y, Lin S, Fan J, Wen Q. Fan Y, et al. Epigenomics. 2019 Nov;11(14):1561-1579. doi: 10.2217/epi-2019-0207. Epub 2019 Oct 4. Epigenomics. 2019. PMID: 31584294
High ADCY4 expression was correlated with better survival of patients with breast cancer and its different intrinsic subtypes and tumor stages. ...Conclusion: ADCY4 may be used as an epigenetic biomarker for breast cancer, as well as a possible target for therapy... …
High ADCY4 expression was correlated with better survival of patients with breast cancer and its different intrinsic subtypes and tum …
ADCY4 inhibits cAMP-induced growth of breast cancer by inactivating FAK/AKT and ERK signaling but is frequently silenced by DNA methylation.
Pan G, Huang M, Fu S, Wang Y, He L, Wu B, Yang J, Lin S, Fan Y. Pan G, et al. Sci Rep. 2025 Jul 1;15(1):20426. doi: 10.1038/s41598-025-06294-1. Sci Rep. 2025. PMID: 40594405 Free PMC article.
DNA methyltransferase inhibitor and histone deacetylase inhibitor can restore ADCY4 mRNA expression in ADCY4-silenced BC cells. ADCY4 directly affects BC cell proliferation, apoptosis, invasion, and metastasis. ...Also, ADCY4 increases BC cell chemosen …
DNA methyltransferase inhibitor and histone deacetylase inhibitor can restore ADCY4 mRNA expression in ADCY4-silenced BC cells …
Low Expression of ADCY4 Predicts Worse Survival of Lung Squamous Cell Carcinoma Based on Integrated Analysis and Immunohistochemical Verification.
Liu Z, Ru L, Ma Z. Liu Z, et al. Front Oncol. 2021 Jun 10;11:637733. doi: 10.3389/fonc.2021.637733. eCollection 2021. Front Oncol. 2021. PMID: 34178627 Free PMC article.
Additionally, GSEA analysis showed that spliceosome and cell adhesion molecules were associated with the expression of GNG11 and ADCY4, respectively. The GSE30219 and THPA databases and IHC results from the real world indicated that although GNG11 was not detected, ADCY …
Additionally, GSEA analysis showed that spliceosome and cell adhesion molecules were associated with the expression of GNG11 and ADCY4 …
cAMP metabolism controls caspase-11 inflammasome activation and pyroptosis in sepsis.
Chen R, Zeng L, Zhu S, Liu J, Zeh HJ, Kroemer G, Wang H, Billiar TR, Jiang J, Tang D, Kang R. Chen R, et al. Sci Adv. 2019 May 22;5(5):eaav5562. doi: 10.1126/sciadv.aav5562. eCollection 2019 May. Sci Adv. 2019. PMID: 31131320 Free PMC article.
Here, we demonstrate that l-adrenaline can act on receptor ADRA2B to inhibit the activation of the caspase-11 inflammasome by cytosolic LPS or Escherichia coli infection in macrophages. l-adrenaline-induced cAMP production via the enzyme ADCY4 promotes protein kinase A (PK …
Here, we demonstrate that l-adrenaline can act on receptor ADRA2B to inhibit the activation of the caspase-11 inflammasome by cytosolic LPS …
Plexin C1 influences immune response to intracellular LPS and survival in murine sepsis.
Bernard A, Eggstein C, Tang L, Keller M, Körner A, Mirakaj V, Rosenberger P. Bernard A, et al. J Biomed Sci. 2024 Aug 21;31(1):82. doi: 10.1186/s12929-024-01074-x. J Biomed Sci. 2024. PMID: 39169397 Free PMC article.
RESULTS: We found the neuronal guidance receptor PLXNC1 dampens the intracellular response to LPS by interacting with adenylate cyclase 4 (ADCY4) and protein kinase A activity, which in turn diminishes caspase-11 expression. ...
RESULTS: We found the neuronal guidance receptor PLXNC1 dampens the intracellular response to LPS by interacting with adenylate cyclase 4 ( …
Expression characteristics of lipid metabolism-related genes and correlative immune infiltration landscape in acute myocardial infarction.
Wu J, Luo J, Cai H, Zhu H, Lei Z, Lu Y, Gao X, Ni L, Lu Z, Hu X. Wu J, et al. Sci Rep. 2024 Jun 18;14(1):14095. doi: 10.1038/s41598-024-65022-3. Sci Rep. 2024. PMID: 38890389 Free PMC article.
These genes were mainly related to "leukotriene production involved in inflammatory response", "lipoxygenase pathway", "metabolic pathways", and "regulation of lipolysis in adipocytes" pathways. 12 LMRGs (ACSL1, ADCY4, ALOX5, ALOX5AP, CCL5, CEBPB, CEBPD, CREB5, GAB2, PISD, …
These genes were mainly related to "leukotriene production involved in inflammatory response", "lipoxygenase pathway", "metabolic pathways", …
Solanine induces ferroptosis in colorectal cancer cells through ALOX12B/ADCY4 molecular axis.
Ma X, Li Y, Liang D, Jiang F, Zhang L, Song W, Wan B, Xia C, Lu Q. Ma X, et al. J Pharm Pharmacol. 2024 Mar 4;76(3):224-235. doi: 10.1093/jpp/rgad122. J Pharm Pharmacol. 2024. PMID: 38244223
Solanine treatment upregulated ALOX12B levels and silencing ALOX12B could suppress solanine-induced ferroptosis. Further, ADCY4 was found to physically associate with ALOX12B and maintain ALOX12B protein stability. Silencing ADCY4 destabilized ALOX12B and attenuated …
Solanine treatment upregulated ALOX12B levels and silencing ALOX12B could suppress solanine-induced ferroptosis. Further, ADCY4 was f …
Contributions of specificity protein-1 and steroidogenic factor 1 to Adcy4 expression in Y1 mouse adrenal cells.
Rui X, Tsao J, Scheys JO, Hammer GD, Schimmer BP. Rui X, et al. Endocrinology. 2008 Jul;149(7):3668-78. doi: 10.1210/en.2008-0203. Epub 2008 Apr 3. Endocrinology. 2008. PMID: 18388192 Free PMC article.
This study examines the contributions of SF1 and other DNA promoter/regulatory elements to Adcy4 expression in the Y1 cell line and its derivative Adcy4-deficient mutant. Primer extension and in silico analyses indicate that Adcy4 transcription initiates from …
This study examines the contributions of SF1 and other DNA promoter/regulatory elements to Adcy4 expression in the Y1 cell line and i …
Construction of a tumor mutational burden-derived LncRNA prognostic computational framework associated with therapy sensitivity in skin cutaneous melanoma.
Li G, Wu T, Li H, Wei C, Sun Y, Gao P, Huang X, Liu Z, Li J, Wang Y, Li G, Fan L. Li G, et al. J Transl Med. 2024 Oct 24;22(1):966. doi: 10.1186/s12967-024-05732-4. J Transl Med. 2024. PMID: 39449143 Free PMC article.
Moreover, it resulted in the downregulation of ADCY4, PRKACA, and SOX10 gene expression, as well as decreased protein expression of ADCY4, PRKACA, and SOX10. ...Overall, the findings underscore the potential of novel computational frameworks like TILPI in predicting …
Moreover, it resulted in the downregulation of ADCY4, PRKACA, and SOX10 gene expression, as well as decreased protein expression of …
49 results