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Page 1
The Adhesion GPCR ADGRL2/LPHN2 Can Protect Against Cellular and Organismal Dysfunction.
Jakobs P, Rafflenbeul A, Post WB, Ale-Agha N, Groß VE, Pick S, Dolata S, Cox FF, von Ameln F, Eckermann O, Altschmied J, Prömel S, Haendeler J. Jakobs P, et al. Cells. 2024 Nov 5;13(22):1826. doi: 10.3390/cells13221826. Cells. 2024. PMID: 39594576 Free PMC article.
Adhesion GPCRs (aGPCRs) have been largely overlooked in this context, although particularly one of them, ADGRL2/LPHN2, has been implicated in endothelial barrier function. Our study shows that overexpression of ADGRL2 protects endothelial cells from LPS-induced acti …
Adhesion GPCRs (aGPCRs) have been largely overlooked in this context, although particularly one of them, ADGRL2/LPHN2, has been impli …
International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.
Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB. Hamann J, et al. Pharmacol Rev. 2015;67(2):338-67. doi: 10.1124/pr.114.009647. Pharmacol Rev. 2015. PMID: 25713288 Free PMC article. Review.
The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 …
The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADG …
PCLAF induces bone marrow adipocyte senescence and contributes to skeletal aging.
Xie L, Cheng Y, Hu B, Chen X, An Y, Xia Z, Cai G, Li C, Peng H. Xie L, et al. Bone Res. 2024 Jul 4;12(1):38. doi: 10.1038/s41413-024-00337-5. Bone Res. 2024. PMID: 38961077 Free PMC article.
In contrast, the transplantation of PCLAF-mediated senescent BMAds into the bone marrow of healthy mice suppressed bone turnover. Mechanistically, PCLAF bound to the ADGRL2 receptor to inhibit AKT/mTOR signaling that triggered BMAds senescence and subsequently spread senes …
In contrast, the transplantation of PCLAF-mediated senescent BMAds into the bone marrow of healthy mice suppressed bone turnover. Mechanisti …
A force-sensitive adhesion GPCR is required for equilibrioception.
Yang Z, Zhou SH, Zhang QY, Song ZC, Liu WW, Sun Y, Wang MW, Fu XL, Zhu KK, Guan Y, Qi JY, Wang XH, Sun YN, Lu Y, Ping YQ, Xi YT, Teng ZX, Xu L, Xiao P, Xu ZG, Xiong W, Qin W, Yang W, Yi F, Chai RJ, Yu X, Sun JP. Yang Z, et al. Cell Res. 2025 Apr;35(4):243-264. doi: 10.1038/s41422-025-01075-x. Epub 2025 Feb 18. Cell Res. 2025. PMID: 39966628 Free PMC article.
Here, we identify the G protein-coupled receptor (GPCR) LPHN2/ADGRL2, expressed on the apical membrane of utricular hair cells, as essential for maintaining normal balance. ...
Here, we identify the G protein-coupled receptor (GPCR) LPHN2/ADGRL2, expressed on the apical membrane of utricular hair cells, as es …
Latrophilin-2 mediates fluid shear stress mechanotransduction at endothelial junctions.
Tanaka K, Chen M, Prendergast A, Zhuang Z, Nasiri A, Joshi D, Hintzen J, Chung M, Kumar A, Mani A, Koleske A, Crawford J, Nicoli S, Schwartz MA. Tanaka K, et al. EMBO J. 2024 Aug;43(15):3175-3191. doi: 10.1038/s44318-024-00142-0. Epub 2024 Jun 17. EMBO J. 2024. PMID: 38886581 Free PMC article.
We next mapped the Galpha residues required for activation and developed an affinity purification method that used this information to identify latrophilin-2 (Lphn2/ADGRL2) as the upstream GPCR. Latrophilin-2 is required for all PECAM-1 downstream events tested. ...Human g …
We next mapped the Galpha residues required for activation and developed an affinity purification method that used this information to ident …
The Adhesion GPCR ADGRL2 engages Galpha13 to Enable Epidermal Differentiation.
Yang X, He F, Porter DF, Garbett K, Meyers RM, Reynolds DL, Lan Huong Bui D, Hong A, Ducoli L, Siprashvili Z, Lopez-Pajares V, Mondal S, Ko L, Jing Y, Tao S, Singal B, Sando R, Skiniotis G, Khavari PA. Yang X, et al. bioRxiv [Preprint]. 2025 Apr 14:2025.02.19.639154. doi: 10.1101/2025.02.19.639154. bioRxiv. 2025. PMID: 40060693 Free PMC article. Preprint.
Dual CRISPR-Flow and single cell Perturb-seq knockout screens of all epidermal GPCRs were thus performed, uncovering an essential requirement for adhesion GPCR ADGRL2 (latrophilin 2) in epidermal differentiation. Among potential downstream guanine nucleotide-binding G prot …
Dual CRISPR-Flow and single cell Perturb-seq knockout screens of all epidermal GPCRs were thus performed, uncovering an essential requiremen …
Parahippocampal latrophilin-2 (ADGRL2) expression controls topographical presubiculum to entorhinal cortex circuit connectivity.
Donohue JD, Amidon RF, Murphy TR, Wong AJ, Liu ED, Saab L, King AJ, Pae H, Ajayi MT, Anderson GR. Donohue JD, et al. Cell Rep. 2021 Nov 23;37(8):110031. doi: 10.1016/j.celrep.2021.110031. Cell Rep. 2021. PMID: 34818557 Free article.
Focusing on parahippocampal circuitry, we find that latrophilin-2 (Lphn2; gene symbol ADGRL2) is specifically enriched in interconnected subregions of the medial entorhinal cortex (MEC), presubiculum (PrS), and parasubiculum (PaS). ...
Focusing on parahippocampal circuitry, we find that latrophilin-2 (Lphn2; gene symbol ADGRL2) is specifically enriched in interconnec …
A de novo variant in ADGRL2 suggests a novel mechanism underlying the previously undescribed association of extreme microcephaly with severely reduced sulcation and rhombencephalosynapsis.
Vezain M, Lecuyer M, Rubio M, Dupé V, Ratié L, David V, Pasquier L, Odent S, Coutant S, Tournier I, Trestard L, Adle-Biassette H, Vivien D, Frébourg T, Gonzalez BJ, Laquerrière A, Saugier-Veber P. Vezain M, et al. Acta Neuropathol Commun. 2018 Oct 19;6(1):109. doi: 10.1186/s40478-018-0610-5. Acta Neuropathol Commun. 2018. PMID: 30340542 Free PMC article.
Furthermore, HeLa cells overexpressing mutant ADGRL2 displayed a highly developed cytoplasmic F-actin network related to cytoskeletal dynamic modulation. ADGRL2 is the first gene identified as being responsible for extreme microcephaly with rhombencephalosynapsis. . …
Furthermore, HeLa cells overexpressing mutant ADGRL2 displayed a highly developed cytoplasmic F-actin network related to cytoskeletal …
Cartography of teneurin and latrophilin expression reveals spatiotemporal axis heterogeneity in the mouse hippocampus during development.
Liakath-Ali K, Refaee R, Südhof TC. Liakath-Ali K, et al. PLoS Biol. 2024 May 7;22(5):e3002599. doi: 10.1371/journal.pbio.3002599. eCollection 2024 May. PLoS Biol. 2024. PMID: 38713721 Free PMC article.
Recent studies suggest that Tenm3 and Lphn2 (gene symbol Adgrl2) are involved in hippocampal circuit assembly via their topographical expression. ...
Recent studies suggest that Tenm3 and Lphn2 (gene symbol Adgrl2) are involved in hippocampal circuit assembly via their topographical …
Latrophilin-2 mediates fluid shear stress mechanotransduction at endothelial junctions.
Tanaka K, Chen M, Prendergast A, Zhuang Z, Nasiri A, Joshi D, Hintzen J, Chung M, Kumar A, Mani A, Koleske A, Crawford J, Nicoli S, Schwartz MA. Tanaka K, et al. bioRxiv [Preprint]. 2024 Jun 14:2024.06.13.598386. doi: 10.1101/2024.06.13.598386. bioRxiv. 2024. Update in: EMBO J. 2024 Aug;43(15):3175-3191. doi: 10.1038/s44318-024-00142-0. PMID: 38915515 Free PMC article. Updated. Preprint.
We next mapped the Galpha residues required for activation and developed an affinity purification method that used this information to identify latrophilin-2 (Lphn-2/ADGRL2) as the upstream GPCR. Latrophilin-2 is required for all PECAM-1 downstream events tested. ...Human …
We next mapped the Galpha residues required for activation and developed an affinity purification method that used this information to ident …
38 results