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Year Number of Results
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197 results

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Page 1
Single-cell transcriptomics analysis of proliferative diabetic retinopathy fibrovascular membranes reveals AEBP1 as fibrogenesis modulator.
Corano Scheri K, Lavine JA, Tedeschi T, Thomson BR, Fawzi AA. Corano Scheri K, et al. JCI Insight. 2023 Nov 2;8(23):e172062. doi: 10.1172/jci.insight.172062. JCI Insight. 2023. PMID: 37917183 Free PMC article.
Differentially expressed gene analysis showed that Adipocyte Enhancer-binding Protein 1, AEBP1, was significantly upregulated in myofibroblast clusters, suggesting that this molecule may have a role in transformation. ...In conclusion, AEBP1 signaling modulates peri …
Differentially expressed gene analysis showed that Adipocyte Enhancer-binding Protein 1, AEBP1, was significantly upregulated in myof …
AEBP1 is a Novel Oncogene: Mechanisms of Action and Signaling Pathways.
Majdalawieh AF, Massri M, Ro HS. Majdalawieh AF, et al. J Oncol. 2020 May 27;2020:8097872. doi: 10.1155/2020/8097872. eCollection 2020. J Oncol. 2020. PMID: 32565808 Free PMC article. Review.
Several years ago, we first reported the ability of AEBP1 to exert a positive control over the canonical NF-kappaB pathway. Indeed, AEBP1 positively regulates NF-kappaB activity via its direct interaction with IkappaBalpha, a key NF-kappaB inhibitor. AEBP1 ov …
Several years ago, we first reported the ability of AEBP1 to exert a positive control over the canonical NF-kappaB pathway. Indeed, …
AEBP1 or ACLP, which is the key factor in inflammation and fibrosis?
Runtian Z, Wenqiang H, Zimeng S, Tianyu W, Jingquan Z. Runtian Z, et al. Int J Biol Macromol. 2025 May;310(Pt 4):143554. doi: 10.1016/j.ijbiomac.2025.143554. Epub 2025 Apr 26. Int J Biol Macromol. 2025. PMID: 40294683 Review.
Adipocyte enhancer-binding protein 1 (AEBP1) and Aortic carboxypeptidase-like protein (ACLP) are two protein isoforms produced by the AEBP1 gene. ...Current research suggests that the AEBP1 gene encodes two proteins, AEBP1 and ACLP, which have been rep …
Adipocyte enhancer-binding protein 1 (AEBP1) and Aortic carboxypeptidase-like protein (ACLP) are two protein isoforms produced by the …
AEBP1 promotes papillary thyroid cancer progression by activating BMP4 signaling.
Ju G, Xing T, Xu M, Zhang X, Sun Y, Mu Z, Sun D, Miao S, Li L, Liang J, Lin Y. Ju G, et al. Neoplasia. 2024 Mar;49:100972. doi: 10.1016/j.neo.2024.100972. Epub 2024 Jan 18. Neoplasia. 2024. PMID: 38237535 Free PMC article.
In the xenograft model, knockout of AEBP1 inhibited the growth and lung metastasis of PTC cells. By performing RNA-sequencing, dual-luciferase reporter assay, and chromatin immunoprecipitation assay, Bone morphogenetic protein 4 (BMP4) was identified as a downstream target …
In the xenograft model, knockout of AEBP1 inhibited the growth and lung metastasis of PTC cells. By performing RNA-sequencing, dual-l …
AEBP1 restores osteoblastic differentiation under dexamethasone treatment by activating PI3K/AKT signalling.
Jin R, Li C, Yang Y, Xie J. Jin R, et al. Clin Exp Pharmacol Physiol. 2024 Nov;51(11):e13923. doi: 10.1111/1440-1681.13923. Clin Exp Pharmacol Physiol. 2024. PMID: 39358837
They were then further transfected with control or AEBP1-overexpressed lentiviral vectors. Finally, cells were treated with the PI3K inhibitor LY294002, with or without AEBP1-overexpressed lentiviral vectors. AEBP1 expression showed a downward trend in MC3T3- …
They were then further transfected with control or AEBP1-overexpressed lentiviral vectors. Finally, cells were treated with the PI3K …
AEBP1 is a negative regulator of skeletal muscle cell differentiation in oral squamous cell carcinoma.
Okazaki F, Yorozu A, Sekiguchi S, Niinuma T, Maruyama R, Kitajima H, Yamamoto E, Ishiguro K, Toyota M, Hatanaka Y, Nishiyama K, Ogi K, Kai M, Takano K, Ichimiya S, Miyazaki A, Suzuki H. Okazaki F, et al. Sci Rep. 2024 Nov 9;14(1):27425. doi: 10.1038/s41598-024-79061-3. Sci Rep. 2024. PMID: 39521917 Free PMC article.
Conversely, ectopic expression of AEBP1 strongly suppressed myogenesis-related genes in HSMMs. Notably, indirect co-culture of HSMMs with OSCC cells led to AEBP1 upregulation and robust suppression of muscle-related genes in HSMMs. Treatment with TGF-beta1 also upre …
Conversely, ectopic expression of AEBP1 strongly suppressed myogenesis-related genes in HSMMs. Notably, indirect co-culture of HSMMs …
AEBP1 Contributes to Breast Cancer Progression by Facilitating Cell Proliferation, Migration, Invasion, and Blocking Apoptosis.
Li J, Ruan Y, Zheng C, Pan Y, Lin B, Chen Q, Zheng Z. Li J, et al. Discov Med. 2023 Feb 1;35(174):45-56. doi: 10.24976/Discov.Med.202335174.6. Discov Med. 2023. PMID: 37024441 Free article.
However, the contribution of AEBP1 in breast cancer (BCa) remains inexplicable. METHODS: Information related to the diagnostic significance and expression of AEBP1 in BCa was obtained from the public dataset Kaplan-Meier Plotter (http://kmplot.com/analysis/) and the …
However, the contribution of AEBP1 in breast cancer (BCa) remains inexplicable. METHODS: Information related to the diagnostic signif …
Inhibition of AEBP1 predisposes cisplatin-resistant oral cancer cells to ferroptosis.
Zhou Q, Wang X, Zhang Y, Wang L, Chen Z. Zhou Q, et al. BMC Oral Health. 2022 Nov 9;22(1):478. doi: 10.1186/s12903-022-02503-9. BMC Oral Health. 2022. PMID: 36352396 Free PMC article.
RESULTS: AEBP1 was highly expressed in oral cancer cells and tissues. AEBP1 silencing inhibited oral cancer cell proliferation, migration, and invasion after SSZ treatment. ...Importantly, AEBP1 silencing suppressed tumor growth in vivo. Furthermore, silencin …
RESULTS: AEBP1 was highly expressed in oral cancer cells and tissues. AEBP1 silencing inhibited oral cancer cell proliferation …
Cancer-associated fibroblasts in colorectal cancer.
Kamali Zonouzi S, Pezeshki PS, Razi S, Rezaei N. Kamali Zonouzi S, et al. Clin Transl Oncol. 2022 May;24(5):757-769. doi: 10.1007/s12094-021-02734-2. Epub 2021 Nov 28. Clin Transl Oncol. 2022. PMID: 34839457 Review.
Some genes related to the CAFs which are found to be possible therapeutic targets include COL3A1, JAM3, AEBP1 and, CAF-derived TGFB3, WNT2, and WNT54....
Some genes related to the CAFs which are found to be possible therapeutic targets include COL3A1, JAM3, AEBP1 and, CAF-derived TGFB3, …
AEBP1 as a potential immune-related prognostic biomarker in glioblastoma: a bioinformatic analyses.
Liu M, Yu Y, Zhang Z, Chen Z, Chen B, Cheng Y, Wei Y, Li J, Shang H. Liu M, et al. Ann Transl Med. 2021 Nov;9(22):1657. doi: 10.21037/atm-21-5183. Ann Transl Med. 2021. PMID: 34988166 Free PMC article.
RESULTS: The Oncomine database revealed that AEBP1 was highly expressed in GBM. The prognostic analyses of 4 independent databases (i.e., TCGA, GTEx, Oncomine, and CGGA) revealed that AEBP1 was an independent predictable marker of GBM. ...CONCLUSIONS: High AEBP1 …
RESULTS: The Oncomine database revealed that AEBP1 was highly expressed in GBM. The prognostic analyses of 4 independent databases (i …
197 results