Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2011 2
2012 1
2013 2
2014 2
2015 1
2016 3
2018 1
2020 1
2021 3
2023 2
2025 4
2026 1

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

21 results

Results by year

Filters applied: . Clear all
Page 1
Hypoxia-induced AFAP1L1 regulates pathological neovascularization via the YAP-DLL4-NOTCH axis.
Ren JS, Bai W, Ding JJ, Ge HM, Wang SY, Chen X, Jiang Q. Ren JS, et al. J Transl Med. 2023 Sep 22;21(1):651. doi: 10.1186/s12967-023-04503-x. J Transl Med. 2023. PMID: 37737201 Free PMC article.
Mechanistically, AFAP1L1 functions as a hypoxia-related regulatory protein that can be activated by HIF-1alpha. ...CONCLUSION: In conclusion, AFAP1L1, a newly identified hypoxia-related regulatory protein, can be activated by HIF-1alpha. ...
Mechanistically, AFAP1L1 functions as a hypoxia-related regulatory protein that can be activated by HIF-1alpha. ...CONCLUSION: In con …
AFAP1L1 promotes gastric cancer progression by interacting with VAV2 to facilitate CDC42-mediated activation of ITGA5 signaling pathway.
Sun B, Ding B, Chen Y, Peng C, Chen X. Sun B, et al. J Transl Med. 2023 Jan 11;21(1):18. doi: 10.1186/s12967-023-03871-8. J Transl Med. 2023. PMID: 36631800 Free PMC article.
Besides, only AFAP1L1 could predict poor prognosis and act as an independent risk factor for GC patients. ...CONCLUSION: AFAP1L1 promotes GC progression by inducing EMT through VAV2-mediated activation of CDC42 and ITGA5 signaling pathway, indicating AFAP1L1 …
Besides, only AFAP1L1 could predict poor prognosis and act as an independent risk factor for GC patients. ...CONCLUSION: AFAP1L1 …
AFAP1L1 is a novel adaptor protein of the AFAP family that interacts with cortactin and localizes to invadosomes.
Snyder BN, Cho Y, Qian Y, Coad JE, Flynn DC, Cunnick JM. Snyder BN, et al. Eur J Cell Biol. 2011 May;90(5):376-89. doi: 10.1016/j.ejcb.2010.11.016. Epub 2011 Feb 18. Eur J Cell Biol. 2011. PMID: 21333378 Free PMC article.
A homology search of AFAP1 recently identified AFAP1L1 which has a similar sequence, domain structure and cellular localization; however, based upon sequence variations, AFAP1L1 is hypothesized to have unique functions that are distinct from AFAP1. ...We hypothesize …
A homology search of AFAP1 recently identified AFAP1L1 which has a similar sequence, domain structure and cellular localization; howe …
AFAP1L1, a novel associating partner with vinculin, modulates cellular morphology and motility, and promotes the progression of colorectal cancers.
Takahashi R, Nagayama S, Furu M, Kajita Y, Jin Y, Kato T, Imoto S, Sakai Y, Toguchida J. Takahashi R, et al. Cancer Med. 2014 Aug;3(4):759-74. doi: 10.1002/cam4.237. Epub 2014 Apr 10. Cancer Med. 2014. PMID: 24723436 Free PMC article.
AFAP1L1 localized to the ringed structure of the invadopodia, together with vinculin, and AFAP1L1 was identified as a novel associating partner of vinculin by immunoprecipitation assay. AFAP1L1-transduced cells showed accelerated tumor growth in vivo, presuma …
AFAP1L1 localized to the ringed structure of the invadopodia, together with vinculin, and AFAP1L1 was identified as a novel as …
Regulation of sarcoma cell migration, invasion and invadopodia formation by AFAP1L1 through a phosphotyrosine-dependent pathway.
Tie SR, McCarthy DJ, Kendrick TS, Louw A, Le C, Satiaputra J, Kucera N, Phillips M, Ingley E. Tie SR, et al. Oncogene. 2016 Apr 21;35(16):2098-111. doi: 10.1038/onc.2015.272. Epub 2015 Jul 27. Oncogene. 2016. PMID: 26212012 Free article.
These phosphotyrosine motifs are essential for AFAP1L1-mediated cytoskeleton regulation. Through its interaction with Vav2, AFAP1L1 regulates Rac activity and downstream control of PAK1/2/3 (p21-activated kinases) phosphorylation of myosin light chain (MLC) kinase a …
These phosphotyrosine motifs are essential for AFAP1L1-mediated cytoskeleton regulation. Through its interaction with Vav2, AFAP1L …
Identification of AFAP1L1 as a prognostic marker for spindle cell sarcomas.
Furu M, Kajita Y, Nagayama S, Ishibe T, Shima Y, Nishijo K, Uejima D, Takahashi R, Aoyama T, Nakayama T, Nakamura T, Nakashima Y, Ikegawa M, Imoto S, Katagiri T, Nakamura Y, Toguchida J. Furu M, et al. Oncogene. 2011 Sep 22;30(38):4015-25. doi: 10.1038/onc.2011.108. Epub 2011 Apr 25. Oncogene. 2011. PMID: 21516130
Immunohistochemical staining using paraffin-embedded tumor tissues revealed that the metastasis-free rate was significantly better in tumors negative for AFAP1L1 (P=0.0093 by log-rank test). Knocking down the AFAP1L1 gene in sarcoma cells resulted in inhibition of t …
Immunohistochemical staining using paraffin-embedded tumor tissues revealed that the metastasis-free rate was significantly better in tumors …
The transcription factor Sp3 regulates the expression of a metastasis-related marker of sarcoma, actin filament-associated protein 1-like 1 (AFAP1L1).
Kajita Y, Kato T Jr, Tamaki S, Furu M, Takahashi R, Nagayama S, Aoyama T, Nishiyama H, Nakamura E, Katagiri T, Nakamura Y, Ogawa O, Toguchida J. Kajita Y, et al. PLoS One. 2013;8(1):e49709. doi: 10.1371/journal.pone.0049709. Epub 2013 Jan 9. PLoS One. 2013. PMID: 23326307 Free PMC article.
Chromatin immunoprecipitation experiments, however, revealed that Sp3 is the major factor binding to the proximal promoter region of the AFAP1L1 gene in AFAP1L1- positive cells. Treatment with mithramycin A, an inhibitor of proteins binding to GC-rich regions, preve …
Chromatin immunoprecipitation experiments, however, revealed that Sp3 is the major factor binding to the proximal promoter region of the …
Identification and validation of AFAP1L1 as an immune-related prognostic biomarker in clear cell renal cell carcinoma.
Yan Q, Zhang B, Yu Y, Si Y, Zhang Y, Ye Z, Zhang Q, Wu W, Luo X, Biao X. Yan Q, et al. Biomarkers. 2026 Feb 11:1-21. doi: 10.1080/1354750X.2026.2630072. Online ahead of print. Biomarkers. 2026. PMID: 41674071
AFAP1L1 mRNA expression was measured via quantitative real-time PCR (qRT-PCR) experiment. ...The upregulated DEGs were primarily involved in signaling pathways, nephron development, and transporter activity. AFAP1L1 was positively related with neutrophils and macrop …
AFAP1L1 mRNA expression was measured via quantitative real-time PCR (qRT-PCR) experiment. ...The upregulated DEGs were primarily invo …
Actin Filament-Associated Protein 1-Like 1 Mediates Proliferation and Survival in Non-Small Cell Lung Cancer Cells.
Wang M, Han X, Sun W, Li X, Jing G, Zhang X. Wang M, et al. Med Sci Monit. 2018 Jan 11;24:215-224. doi: 10.12659/msm.905900. Med Sci Monit. 2018. PMID: 29323101 Free PMC article.
The PathScan intracellular signaling array was used to investigate cancer-related signaling proteins influenced by knocking down AFAP1L1 in A549. RESULTS AFAP1L1 gene expression was successfully inhibited by the AFAP1L1-shRNA transfection. ...Therefore, AF …
The PathScan intracellular signaling array was used to investigate cancer-related signaling proteins influenced by knocking down AFAP1L1 …
Exome and Genome Sequencing Reveals Novel Variants for Severe Diabetic Retinopathy in Type 1 Diabetes.
Vuori N, Antikainen AA, Haukka JK, Harjutsalo V, Groop PH, Sandholm N; FinnDiane Study Group. Vuori N, et al. Invest Ophthalmol Vis Sci. 2025 Oct 1;66(13):36. doi: 10.1167/iovs.66.13.36. Invest Ophthalmol Vis Sci. 2025. PMID: 41129127 Free PMC article.

Gene aggregate analysis results were enriched for genes expressed in the retina and identified seven genes with suggestive association with SDR (P < 1 10-4), with evidence of replication for AFAP1L1, SLC30A9, HPS3, and PELI1. Sliding window analyses revealed a signifi

…
Gene aggregate analysis results were enriched for genes expressed in the retina and identified seven genes with suggestive association with …
21 results