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Synaptic dysregulation and hyperexcitability induced by intracellular amyloid beta oligomers.

Fernandez-Perez EJ, Muñoz B, Bascuñan DA, Peters C, Riffo-Lepe NO, Espinoza MP, Morgan PJ, Filippi C, Bourboulou R, Sengupta U, Kayed R, Epsztein J, Aguayo LG. Fernandez-Perez EJ, et al. Among authors: aguayo lg. Aging Cell. 2021 Sep;20(9):e13455. doi: 10.1111/acel.13455. Epub 2021 Aug 19. Aging Cell. 2021. PMID: 34409748 Free PMC article.

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Structure and Pharmacologic Modulation of Inhibitory Glycine Receptors.

Burgos CF, Yévenes GE, Aguayo LG. Burgos CF, et al. Among authors: aguayo lg. Mol Pharmacol. 2016 Sep;90(3):318-25. doi: 10.1124/mol.116.105726. Epub 2016 Jul 11. Mol Pharmacol. 2016. PMID: 27401877 Free PMC article. Review.

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Modulation of glycine receptor single-channel conductance by intracellular phosphorylation.

Moraga-Cid G, San Martín VP, Lara CO, Muñoz B, Marileo AM, Sazo A, Muñoz-Montesino C, Fuentealba J, Castro PA, Guzmán L, Burgos CF, Zeilhofer HU, Aguayo LG, Corringer PJ, Yévenes GE. Moraga-Cid G, et al. Among authors: aguayo lg. Sci Rep. 2020 Mar 16;10(1):4804. doi: 10.1038/s41598-020-61677-w. Sci Rep. 2020. PMID: 32179786 Free PMC article.

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The Stimulatory Effects of Intracellular α-Synuclein on Synaptic Transmission Are Attenuated by 2-Octahydroisoquinolin-2(1H)-ylethanamine.

Ramirez AE, Fernández-Pérez EJ, Olivos N, Burgos CF, Boopathi S, Armijo-Weingart L, Pacheco CR, González W, Aguayo LG. Ramirez AE, et al. Among authors: aguayo lg. Int J Mol Sci. 2021 Dec 9;22(24):13253. doi: 10.3390/ijms222413253. Int J Mol Sci. 2021. PMID: 34948050 Free PMC article.

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Complex Interaction between Resident Microbiota and Misfolded Proteins: Role in Neuroinflammation and Neurodegeneration.

González-Sanmiguel J, Schuh CMAP, Muñoz-Montesino C, Contreras-Kallens P, Aguayo LG, Aguayo S. González-Sanmiguel J, et al. Among authors: aguayo lg. Cells. 2020 Nov 13;9(11):2476. doi: 10.3390/cells9112476. Cells. 2020. PMID: 33203002 Free PMC article. Review.

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Gabapentin Inhibits Multiple Steps in the Amyloid Beta Toxicity Cascade.

González-Sanmiguel J, Burgos CF, Bascuñán D, Fernández-Pérez EJ, Riffo-Lepe N, Boopathi S, Fernández-Pérez A, Bobadilla-Azócar C, González W, Figueroa M, Vicente B, Aguayo LG. González-Sanmiguel J, et al. Among authors: aguayo lg. ACS Chem Neurosci. 2020 Oct 7;11(19):3064-3076. doi: 10.1021/acschemneuro.0c00414. Epub 2020 Sep 22. ACS Chem Neurosci. 2020. PMID: 32886489

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Features of alpha-synuclein that could explain the progression and irreversibility of Parkinson's disease.

Gallegos S, Pacheco C, Peters C, Opazo CM, Aguayo LG. Gallegos S, et al. Among authors: aguayo lg. Front Neurosci. 2015 Mar 9;9:59. doi: 10.3389/fnins.2015.00059. eCollection 2015. Front Neurosci. 2015. PMID: 25805964 Free PMC article. Review.

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Boldine Attenuates Synaptic Failure and Mitochondrial Deregulation in Cellular Models of Alzheimer's Disease.

Toledo JP, Fernández-Pérez EJ, Ferreira IL, Marinho D, Riffo-Lepe NO, Pineda-Cuevas BN, Pinochet-Pino LF, Burgos CF, Rego AC, Aguayo LG. Toledo JP, et al. Among authors: aguayo lg. Front Neurosci. 2021 Feb 19;15:617821. doi: 10.3389/fnins.2021.617821. eCollection 2021. Front Neurosci. 2021. PMID: 33679301 Free PMC article.

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Inhibition of the Glycine Receptor alpha 3 Function by Colchicine.

Muñoz-Montesino C, Burgos CF, Lara CO, Riquelme CR, Flaig D, San Martin VP, Aguayo LG, Fuentealba J, Castro PA, Guzmán L, Yévenes GE, Moraga-Cid G. Muñoz-Montesino C, et al. Among authors: aguayo lg. Front Pharmacol. 2020 Jul 30;11:1143. doi: 10.3389/fphar.2020.01143. eCollection 2020. Front Pharmacol. 2020. PMID: 32903667 Free PMC article.

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Contribution of GlyR α3 Subunits to the Sensitivity and Effect of Ethanol in the Nucleus Accumbens.

San Martin LS, Armijo-Weingart L, Araya A, Yévenes GE, Harvey RJ, Aguayo LG. San Martin LS, et al. Among authors: aguayo lg. Front Mol Neurosci. 2021 Oct 22;14:756607. doi: 10.3389/fnmol.2021.756607. eCollection 2021. Front Mol Neurosci. 2021. PMID: 34744627 Free PMC article.

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