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128 results

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Page 1
AIMP1-Derived Peptide Secreted from Hair Follicle Stem Cells Promotes Hair Growth by Activating Dermal Papilla Cells.
Kim Y, Kim SB, Lee H, Kim D, Bak SS, Yoon I, Cho S, Jeong SJ, Jeon Y, Kim J, Kim JH, Oh S, Battogtokh KE, Park MC, Sung YK, Kim S. Kim Y, et al. Int J Biol Sci. 2024 Oct 21;20(14):5764-5778. doi: 10.7150/ijbs.101127. eCollection 2024. Int J Biol Sci. 2024. PMID: 39494335 Free PMC article.
This study demonstrated that a fragment derived from aminoacyl-tRNA synthetase-interacting multifunctional protein1 (AIMP1) secreted from HFSCs activated DPCs and maintained HF homeostasis. A histological analysis revealed that AIMP1 levels in HF decreased with hair …
This study demonstrated that a fragment derived from aminoacyl-tRNA synthetase-interacting multifunctional protein1 (AIMP1) secreted …
AIMP1: multifunctional regulator in physiology and pathology with therapeutic implications.
Yuan X, Wang X, Ma X, Mao Y, Wang Q. Yuan X, et al. PeerJ. 2025 Nov 18;13:e20334. doi: 10.7717/peerj.20334. eCollection 2025. PeerJ. 2025. PMID: 41282993 Free PMC article. Review.
Aminoacyl tRNA synthetase complex interacting multifunctional protein 1 (AIMP1), also referred to as p43, serves as an auxiliary factor of the macromolecular aminoacyl tRNA synthetase complex. ...Furthermore, accumulating studies have demonstrated that AIMP1 is invo …
Aminoacyl tRNA synthetase complex interacting multifunctional protein 1 (AIMP1), also referred to as p43, serves as an auxiliary fact …
Dopaminergic Neuron-Derived AIMP1 Promotes Neurodegeneration via CD23-Dependent Microglial Activation.
Wang Q, Yu H, Yuan X, Li R, Li X, Yin S, Ma X, Wang X. Wang Q, et al. CNS Neurosci Ther. 2025 Jun;31(6):e70472. doi: 10.1111/cns.70472. CNS Neurosci Ther. 2025. PMID: 40522094 Free PMC article.
Aimp1 knockout or knockdown remarkably improved the viability of DA neurons in the MPTP-induced mouse model of PD. Aimp1 deficiency reduced microglial activation in PD mice. RNA-Seq analysis revealed that AIMP1 promoted microglial inflammatory response. ...
Aimp1 knockout or knockdown remarkably improved the viability of DA neurons in the MPTP-induced mouse model of PD. Aimp1 defic …
AIMP1 exerts hearing protection role in age related hearing loss mice by regulating SIRT1 expression.
Peng H, Liu J, Liu Y, Li C, Zhang Z, Hu S, Xie W. Peng H, et al. BMC Geriatr. 2025 Aug 20;25(1):645. doi: 10.1186/s12877-025-06237-5. BMC Geriatr. 2025. PMID: 40836274 Free PMC article.
Finally, D-galactose was administered to mice to establish an ARHL model for verifying the functional role of AIMP1 in ARHL. RESULTS: AIMP1 and SIRT1 were down-regulated in H(2)O(2)-treated HEI-OC1 cells. ...Thus, AIMP1 may be a potential target for ARHL trea …
Finally, D-galactose was administered to mice to establish an ARHL model for verifying the functional role of AIMP1 in ARHL. RESULTS: …
AIMP1 promotes multiple myeloma malignancy through interacting with ANP32A to mediate histone H3 acetylation.
Wei R, Zhu Y, Zhang Y, Zhao W, Yu X, Wang L, Gu C, Gu X, Yang Y. Wei R, et al. Cancer Commun (Lond). 2022 Nov;42(11):1185-1206. doi: 10.1002/cac2.12356. Epub 2022 Aug 30. Cancer Commun (Lond). 2022. PMID: 36042007 Free PMC article.
METHODS: The gene expression profiling cohorts of MM were applied to determine the expression of AIMP1 and its association with MM patient prognosis. Enzyme-linked immunosorbent assay, immunohistochemistry, and Western blotting were used to detect AIMP1 expression. …
METHODS: The gene expression profiling cohorts of MM were applied to determine the expression of AIMP1 and its association with MM pa …
Stepping Out of the Cytosol: AIMp1/p43 Potentiates the Link Between Innate and Adaptive Immunity.
Liang D, Halpert MM, Konduri V, Decker WK. Liang D, et al. Int Rev Immunol. 2015;34(5):367-81. doi: 10.3109/08830185.2015.1077829. Epub 2015 Sep 1. Int Rev Immunol. 2015. PMID: 26325028 Review.
As a structural component of the multi-aminoacyl tRNA synthetase (mARS) complex, AIMp1, also known as p43, hasn't until recently been recognized for its prominent immunological functions. ...AIMp1/p43 deficiency is also correlated with spontaneous Type-2 airway hype …
As a structural component of the multi-aminoacyl tRNA synthetase (mARS) complex, AIMp1, also known as p43, hasn't until recently been …
AIMP1 regulates TCR signaling and induces differentiation of regulatory T cells by interfering with lipid raft association.
Kim MS, Lee A, Cho D, Kim TS. Kim MS, et al. Biochem Biophys Res Commun. 2019 Jun 30;514(3):875-880. doi: 10.1016/j.bbrc.2019.05.040. Epub 2019 May 10. Biochem Biophys Res Commun. 2019. PMID: 31084930
However, the direct effects of AIMP1 on T cells have not yet been reported. In this study, we investigated whether AIMP1 could modulate T cell responses directly. ...In addition, microscopic analysis revealed that lipid raft association in response to TCR engagement …
However, the direct effects of AIMP1 on T cells have not yet been reported. In this study, we investigated whether AIMP1 could …
AIMP1 deficiency enhances airway hyperreactivity in mice via increased TH2 immune responses.
Hong HJ, Kim E, Jung MY, Kim S, Kim TS. Hong HJ, et al. Clin Immunol. 2012 Jun;143(3):256-65. doi: 10.1016/j.clim.2012.02.004. Epub 2012 Mar 3. Clin Immunol. 2012. PMID: 22472603
In this study, we characterized phenotypes of AIMP1-deficient mice and investigated the role of AIMP1 in TH2-biased airway hyperreactivity. Clinical signs of allergic airway inflammation were assessed in AIMP1-deficient mice and the effects of AIMP1 de …
In this study, we characterized phenotypes of AIMP1-deficient mice and investigated the role of AIMP1 in TH2-biased airway hyp …
Pathogenic variants in AIMP1 cause pontocerebellar hypoplasia.
Accogli A, Russell L, Sébire G, Rivière JB, St-Onge J, Addour-Boudrahem N, Laporte AD, Rouleau GA, Saint-Martin C, Srour M. Accogli A, et al. Neurogenetics. 2019 May;20(2):103-108. doi: 10.1007/s10048-019-00572-7. Epub 2019 Mar 28. Neurogenetics. 2019. PMID: 30924036
Pathogenic variants in several aminoacyl-tRNA synthetases genes have been linked to various neurological disorders, including leukodystrophies and pontocerebellar hypoplasias (PCH). To date, loss-of-function variants in AIMP1 have been associated with hypomyelinating leuko …
Pathogenic variants in several aminoacyl-tRNA synthetases genes have been linked to various neurological disorders, including leukodystrophi …
AIMP1 negatively regulates adipogenesis by inhibiting PPARgamma.
Kim JH, Lee JH, Park MC, Yoon I, Kim K, Lee M, Choi HS, Han JM, Kim S. Kim JH, et al. J Cell Sci. 2014 Oct 15;127(Pt 20):4483-93. doi: 10.1242/jcs.154930. Epub 2014 Aug 21. J Cell Sci. 2014. PMID: 25146391
We found that AIMP1 expression increases during adipocyte differentiation. Adipogenesis is augmented in AIMP1-deficient cells, as compared with control cells. AIMP1 exhibits high affinity for active PPARgamma and interacts with the DNA-binding domain of PPARg …
We found that AIMP1 expression increases during adipocyte differentiation. Adipogenesis is augmented in AIMP1-deficient cells, …
128 results