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Year Number of Results
1998 2
2000 1
2001 3
2002 2
2004 1
2006 1
2007 1
2008 1
2009 1
2021 0
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Page 1
A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells.
Wood ER, Truesdale AT, McDonald OB, Yuan D, Hassell A, Dickerson SH, Ellis B, Pennisi C, Horne E, Lackey K, Alligood KJ, Rusnak DW, Gilmer TM, Shewchuk L. Wood ER, et al. Among authors: alligood kj. Cancer Res. 2004 Sep 15;64(18):6652-9. doi: 10.1158/0008-5472.CAN-04-1168. Cancer Res. 2004. PMID: 15374980 Free article.
Synthesis and stereochemical effects of pyrrolidinyl-acetylenic thieno[3,2-d]pyrimidines as EGFR and ErbB-2 inhibitors.
Stevens KL, Alligood KJ, Alberti JG, Caferro TR, Chamberlain SD, Dickerson SH, Dickson HD, Emerson HK, Griffin RJ, Hubbard RD, Keith BR, Mullin RJ, Petrov KG, Gerding RM, Reno MJ, Rheault TR, Rusnak DW, Sammond DM, Smith SC, Uehling DE, Waterson AG, Wood ER. Stevens KL, et al. Among authors: alligood kj. Bioorg Med Chem Lett. 2009 Jan 1;19(1):21-6. doi: 10.1016/j.bmcl.2008.11.023. Epub 2008 Nov 13. Bioorg Med Chem Lett. 2009. PMID: 19028424
The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: potential therapy for cancer.
Rusnak DW, Affleck K, Cockerill SG, Stubberfield C, Harris R, Page M, Smith KJ, Guntrip SB, Carter MC, Shaw RJ, Jowett A, Stables J, Topley P, Wood ER, Brignola PS, Kadwell SH, Reep BR, Mullin RJ, Alligood KJ, Keith BR, Crosby RM, Murray DM, Knight WB, Gilmer TM, Lackey K. Rusnak DW, et al. Among authors: alligood kj. Cancer Res. 2001 Oct 1;61(19):7196-203. Cancer Res. 2001. PMID: 11585755 Free article.
Assessment of epidermal growth factor receptor (EGFR, ErbB1) and HER2 (ErbB2) protein expression levels and response to lapatinib (Tykerb, GW572016) in an expanded panel of human normal and tumour cell lines.
Rusnak DW, Alligood KJ, Mullin RJ, Spehar GM, Arenas-Elliott C, Martin AM, Degenhardt Y, Rudolph SK, Haws TF Jr, Hudson-Curtis BL, Gilmer TM. Rusnak DW, et al. Among authors: alligood kj. Cell Prolif. 2007 Aug;40(4):580-94. doi: 10.1111/j.1365-2184.2007.00455.x. Cell Prolif. 2007. PMID: 17635524 Free PMC article.
Comparison of the biochemical and kinetic properties of the type 1 receptor tyrosine kinase intracellular domains. Demonstration of differential sensitivity to kinase inhibitors.
Brignola PS, Lackey K, Kadwell SH, Hoffman C, Horne E, Carter HL, Stuart JD, Blackburn K, Moyer MB, Alligood KJ, Knight WB, Wood ER. Brignola PS, et al. Among authors: alligood kj. J Biol Chem. 2002 Jan 11;277(2):1576-85. doi: 10.1074/jbc.M105907200. Epub 2001 Nov 5. J Biol Chem. 2002. PMID: 11696537 Free article.
Alkynyl pyrimidines as dual EGFR/ErbB2 kinase inhibitors.
Waterson AG, Stevens KL, Reno MJ, Zhang YM, Boros EE, Bouvier F, Rastagar A, Uehling DE, Dickerson SH, Reep B, McDonald OB, Wood ER, Rusnak DW, Alligood KJ, Rudolph SK. Waterson AG, et al. Among authors: alligood kj. Bioorg Med Chem Lett. 2006 May 1;16(9):2419-22. doi: 10.1016/j.bmcl.2006.01.111. Epub 2006 Feb 17. Bioorg Med Chem Lett. 2006. PMID: 16483772
Potent dipeptide inhibitors of the pp60c-src SH2 domain.
Pacofsky GJ, Lackey K, Alligood KJ, Berman J, Charifson PS, Crosby RM, Dorsey GF Jr, Feldman PL, Gilmer TM, Hummel CW, Jordan SR, Mohr C, Shewchuk LM, Sternbach DD, Rodriguez M. Pacofsky GJ, et al. Among authors: alligood kj. J Med Chem. 1998 May 21;41(11):1894-908. doi: 10.1021/jm970853a. J Med Chem. 1998. PMID: 9599239
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