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Nrf2 activator, sulforaphane ameliorates autism-like symptoms through suppression of Th17 related signaling and rectification of oxidant-antioxidant imbalance in periphery and brain of BTBR T+tf/J mice.
Nadeem A, Ahmad SF, Al-Harbi NO, Attia SM, Bakheet SA, Ibrahim KE, Alqahtani F, Alqinyah M. Nadeem A, et al. Among authors: alqinyah m. Behav Brain Res. 2019 May 17;364:213-224. doi: 10.1016/j.bbr.2019.02.031. Epub 2019 Feb 19. Behav Brain Res. 2019. PMID: 30790585
Sulforaphane treatment reverses corticosteroid resistance in a mixed granulocytic mouse model of asthma by upregulation of antioxidants and attenuation of Th17 immune responses in the airways.
Al-Harbi NO, Nadeem A, Ahmad SF, AlThagfan SS, Alqinyah M, Alqahtani F, Ibrahim KE, Al-Harbi MM. Al-Harbi NO, et al. Among authors: alqinyah m. Eur J Pharmacol. 2019 Jul 15;855:276-284. doi: 10.1016/j.ejphar.2019.05.026. Epub 2019 May 14. Eur J Pharmacol. 2019. PMID: 31100413