Dendrimer end-terminal motif-dependent evasion of human complement and complement activation through IgM hitchhiking.
Wu LP, Ficker M, Christensen JB, Simberg D, Trohopoulos PN, Moghimi SM.
Wu LP, et al.
Nat Commun. 2021 Aug 11;12(1):4858. doi: 10.1038/s41467-021-24960-6.
Nat Commun. 2021.
PMID: 34381048
Free PMC article.
Here we study this using a library of <6 nm poly(amido amine) dendrimers bearing different end-terminal functional groups. Dendrimers are not sensed by C1q and mannan-binding lectin, and hence do not trigger complement activation through these pattern-recognition molecu …
Here we study this using a library of <6 nm poly(amido amine) dendrimers bearing different end-terminal functional groups. Dendrim …