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1998 1
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916 results

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Page 1
Angpt2/Tie2 autostimulatory loop controls tumorigenesis.
Karabid NM, Wiedemann T, Gulde S, Mohr H, Segaran RC, Geppert J, Rohm M, Vitale G, Gaudenzi G, Dicitore A, Ankerst DP, Chen Y, Braren R, Kaissis G, Schilling F, Schillmaier M, Eisenhofer G, Herzig S, Roncaroli F, Honegger JB, Pellegata NS. Karabid NM, et al. EMBO Mol Med. 2022 May 9;14(5):e14364. doi: 10.15252/emmm.202114364. Epub 2022 Mar 10. EMBO Mol Med. 2022. PMID: 35266635 Free PMC article.
ANGPT2 stimulation of TIE2 in tumor cells activates downstream cell proliferation signals, as previously demonstrated in endothelial cells (ECs). ...Thus, the ANGPT2/TIE2 axis provides an exploitable therapeutic target in NF-PitNETs and possibly in other tumors expr …
ANGPT2 stimulation of TIE2 in tumor cells activates downstream cell proliferation signals, as previously demonstrated in endothelial …
Acute respiratory distress syndrome.
Matthay MA, Zemans RL, Zimmerman GA, Arabi YM, Beitler JR, Mercat A, Herridge M, Randolph AG, Calfee CS. Matthay MA, et al. Nat Rev Dis Primers. 2019 Mar 14;5(1):18. doi: 10.1038/s41572-019-0069-0. Nat Rev Dis Primers. 2019. PMID: 30872586 Free PMC article. Review.
Biallelic ANGPT2 loss-of-function causes severe early-onset non-immune hydrops fetalis.
Smeland MF, Brouillard P, Prescott T, Boon LM, Hvingel B, Nordbakken CV, Nystad M, Holla ØL, Vikkula M. Smeland MF, et al. J Med Genet. 2023 Jan;60(1):57-64. doi: 10.1136/jmedgenet-2021-108179. Epub 2021 Dec 7. J Med Genet. 2023. PMID: 34876502 Free PMC article.
CONCLUSION: Pathogenic heterozygous ANGPT2 missense variants were recently shown to cause autosomal dominant primary lymphoedema. ...This is the first report of an autosomal recessive ANGPT2-related disorder in humans....
CONCLUSION: Pathogenic heterozygous ANGPT2 missense variants were recently shown to cause autosomal dominant primary lymphoedema. ... …
Single-cell analysis reveals the implication of vascular endothelial cell-intrinsic ANGPT2 in human intracranial aneurysm.
Yu G, Li J, Zhang H, Zi H, Liu M, An Q, Qiu T, Li P, Song J, Liu P, Quan K, Li S, Liu Y, Zhu W, Du J. Yu G, et al. Cardiovasc Res. 2025 May 6;121(4):658-673. doi: 10.1093/cvr/cvae186. Cardiovasc Res. 2025. PMID: 39187926
The implication of angiogenic regulator ANGPT2 in IA formation and progression, provides a novel potential therapeutical target for IA interventions....
The implication of angiogenic regulator ANGPT2 in IA formation and progression, provides a novel potential therapeutical target for I …
Efficacy, durability, and safety of intravitreal faricimab up to every 16 weeks for neovascular age-related macular degeneration (TENAYA and LUCERNE): two randomised, double-masked, phase 3, non-inferiority trials.
Heier JS, Khanani AM, Quezada Ruiz C, Basu K, Ferrone PJ, Brittain C, Figueroa MS, Lin H, Holz FG, Patel V, Lai TYY, Silverman D, Regillo C, Swaminathan B, Viola F, Cheung CMG, Wong TY; TENAYA and LUCERNE Investigators. Heier JS, et al. Lancet. 2022 Feb 19;399(10326):729-740. doi: 10.1016/S0140-6736(22)00010-1. Epub 2022 Jan 24. Lancet. 2022. PMID: 35085502 Clinical Trial.
Inhibition of ANGPT2 activates autophagy during hypertrophic scar formation via PI3K/AKT/mTOR pathway.
Chen H, Xu K, Sun C, Gui S, Wu J, Wang S. Chen H, et al. An Bras Dermatol. 2023 Jan-Feb;98(1):26-35. doi: 10.1016/j.abd.2021.12.005. Epub 2022 Oct 19. An Bras Dermatol. 2023. PMID: 36272879 Free PMC article.
OBJECTIVE: This study is intended to figure out the role of ANGPT2 and ANGPT2-mediated autophagy during the development of HS. METHODS: RT-qPCR was used to detect ANGPT2 expression in HS tissues and HSFs. HSFs were transfected with sh-ANGPT2 to knock d …
OBJECTIVE: This study is intended to figure out the role of ANGPT2 and ANGPT2-mediated autophagy during the development of HS. …
MYBL1 induces transcriptional activation of ANGPT2 to promote tumor angiogenesis and confer sorafenib resistance in human hepatocellular carcinoma.
Zhu J, Wu Y, Yu Y, Li Y, Shen J, Zhang R. Zhu J, et al. Cell Death Dis. 2022 Aug 20;13(8):727. doi: 10.1038/s41419-022-05180-2. Cell Death Dis. 2022. PMID: 35987690 Free PMC article.
We observed that CD31 staining was significantly increased in tumors formed by MYBL1-overexpressing cells but decreased in MYBL1-silenced tumors. Mechanistically, MYBL1 binds to the ANGPT2 promoter and transcriptionally upregulate ANGPT2 mRNA expression. Strikingly, …
We observed that CD31 staining was significantly increased in tumors formed by MYBL1-overexpressing cells but decreased in MYBL1-silenced tu …
Molecular description of ANGPT2 associated colorectal carcinoma.
Jary M, Hasanova R, Vienot A, Asgarov K, Loyon R, Tirole C, Bouard A, Orillard E, Klajer E, Kim S, Viot J, Colle E, Adotevi O, Bouché O, Lecomte T, Borg C, Feugeas JP. Jary M, et al. Int J Cancer. 2020 Oct 1;147(7):2007-2018. doi: 10.1002/ijc.32993. Epub 2020 May 22. Int J Cancer. 2020. PMID: 32222972
Angiopoietin-2 (ANGPT2) is a prognostic factor in metastatic colorectal cancer (CRC). Nevertheless, it remains to be elucidated which molecular characteristics make up the ANGPT2-related poor-prognosis CRC subset. ...A prognostic model was proposed using seric level …
Angiopoietin-2 (ANGPT2) is a prognostic factor in metastatic colorectal cancer (CRC). Nevertheless, it remains to be elucidated which …
Faricimab Treat-and-Extend for Diabetic Macular Edema: Two-Year Results from the Randomized Phase 3 YOSEMITE and RHINE Trials.
Wong TY, Haskova Z, Asik K, Baumal CR, Csaky KG, Eter N, Ives JA, Jaffe GJ, Korobelnik JF, Lin H, Murata T, Ruamviboonsuk P, Schlottmann PG, Seres AI, Silverman D, Sun X, Tang Y, Wells JA, Yoon YH, Wykoff CC; YOSEMITE and RHINE Investigators. Wong TY, et al. Ophthalmology. 2024 Jun;131(6):708-723. doi: 10.1016/j.ophtha.2023.12.026. Epub 2023 Dec 28. Ophthalmology. 2024. PMID: 38158159 Free article. Clinical Trial.
916 results