p-TSA.H2O mediated one-pot, multi-component synthesis of isatin derived imidazoles as dual-purpose drugs against inflammation and cancer.
Rajesh Kumar M, Violet Dhayabaran V, Sudhapriya N, Manikandan A, Gideon DA, Annapoorani S.
Rajesh Kumar M, et al.
Bioorg Chem. 2020 Sep;102:104046. doi: 10.1016/j.bioorg.2020.104046. Epub 2020 Jun 26.
Bioorg Chem. 2020.
PMID: 32688115
Antioxidant, anti-breast cancer and anti-inflammatory activities of these 13 isatin-based derivatives (named as 5a-m) were assessed. The inhibitory effects of these compounds were tested in vitro against cyclooxygenase-2 (COX-2, an enzyme responsible for inflammation) and …
Antioxidant, anti-breast cancer and anti-inflammatory activities of these 13 isatin-based derivatives (named as 5a-m) were assessed. …