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Whole-exome sequencing reveals ANO8 as a genetic risk factor for intrahepatic cholestasis of pregnancy.
Liu X, Lai H, Zeng X, Xin S, Nie L, Liang Z, Wu M, Chen Y, Zheng J, Zou Y. Liu X, et al. BMC Pregnancy Childbirth. 2020 Sep 17;20(1):544. doi: 10.1186/s12884-020-03240-z. BMC Pregnancy Childbirth. 2020. PMID: 32942997 Free PMC article.
In addition, WES analysis indicated that the gene ANO8 involved in the transport of bile salts is newly identified as associated with ICP. The functional network of the ANO8 gene confirmed this finding. ANO8 contained 8 rare missense mutations that were found …
In addition, WES analysis indicated that the gene ANO8 involved in the transport of bile salts is newly identified as associated with …
VSI: The anoctamins: Structure and function: "Intracellular" anoctamins.
Kunzelmann K, Ousingsawat J, Schreiber R. Kunzelmann K, et al. Cell Calcium. 2024 Jun;120:102888. doi: 10.1016/j.ceca.2024.102888. Epub 2024 Apr 17. Cell Calcium. 2024. PMID: 38657371 Free article. Review.
Probably all intracellular anoctamins except of ANO8 operate as intracellular phospholipid (PL) scramblases, allowing for Ca(2+)-activated, passive transport of phospholipids like phosphatidylserine between both membrane leaflets. ...
Probably all intracellular anoctamins except of ANO8 operate as intracellular phospholipid (PL) scramblases, allowing for Ca(2+)-acti …
Rare genetic variants confer a high risk of ADHD and implicate neuronal biology.
Demontis D, Duan J, Hsu YH, Pintacuda G, Grove J, Nielsen TT, Thirstrup J, Martorana M, Botts T, Satterstrom FK, Bybjerg-Grauholm J, Tsai JHY, Glerup S, Hoogman M, Buitelaar J, Klein M, Ziegler GC, Jacob C, Grimm O, Bayas M, Kobayashi NF, Kittel-Schneider S, Lesch KP, Franke B, Reif A, Agerbo E, Werge T, Nordentoft M, Mors O, Mortensen PB, Lage K, Daly MJ, Neale BM, Børglum AD. Demontis D, et al. Nature. 2026 Jan;649(8098):909-917. doi: 10.1038/s41586-025-09702-8. Epub 2025 Nov 12. Nature. 2026. PMID: 41224997 Free PMC article.

Here, by analysing rare coding variants in exome-sequencing data from 8,895 individuals with ADHD and 53,780 control individuals, we identify three genes (MAP1A, ANO8 and ANK2; P < 3.07 10(-6); odds ratios 5.55-15.13) that are implicated in ADHD. The protein-protein int

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Here, by analysing rare coding variants in exome-sequencing data from 8,895 individuals with ADHD and 53,780 control individuals, we identif …
Expression and function of epithelial anoctamins.
Kunzelmann K, Schreiber R, Kmit A, Jantarajit W, Martins JR, Faria D, Kongsuphol P, Ousingsawat J, Tian Y. Kunzelmann K, et al. Exp Physiol. 2012 Feb;97(2):184-92. doi: 10.1113/expphysiol.2011.058206. Epub 2011 Sep 9. Exp Physiol. 2012. PMID: 21908539 Free article.
Anoctamins 1 and 6 are frequent in epithelial cells, often coexpressed together with Ano8, Ano9 and Ano10. Most available data on anoctamins were obtained from mouse tissues and from cultured cells, which may not be representative of native human tissues....
Anoctamins 1 and 6 are frequent in epithelial cells, often coexpressed together with Ano8, Ano9 and Ano10. Most available data on ano …
Circ_0049979 ameliorates myocardial infarction through improving Cx43-mediated endothelial functions.
Sun M, Zhai S, Gao Y, Hu N, Wang R, Zhang R. Sun M, et al. Toxicol Appl Pharmacol. 2024 Nov;492:117121. doi: 10.1016/j.taap.2024.117121. Epub 2024 Oct 9. Toxicol Appl Pharmacol. 2024. PMID: 39384044
The aim of the present study was to explore the role of circ_0049979, a novel identified circRNA from ANO8 gene locus, in endothelial injury during CHD. We found that expression of circ_0049979 was reduced by ox-LDL treatment in HUVECs in a dose-dependent manner. ...
The aim of the present study was to explore the role of circ_0049979, a novel identified circRNA from ANO8 gene locus, in endothelial …
Expression of MHC class I, HLA-A and HLA-B identifies immune-activated breast tumors with favorable outcome.
Noblejas-López MDM, Nieto-Jiménez C, Morcillo García S, Pérez-Peña J, Nuncia-Cantarero M, Andrés-Pretel F, Galán-Moya EM, Amir E, Pandiella A, Győrffy B, Ocana A. Noblejas-López MDM, et al. Oncoimmunology. 2019 Jul 3;8(10):e1629780. doi: 10.1080/2162402X.2019.1629780. eCollection 2019. Oncoimmunology. 2019. PMID: 31646075 Free PMC article.
Several neopeptides expressed in breast cancer were also identified including FUK, SNAPC3, GC, ANO8, DOT1L, HIST1H3F, MYBPH, STX2, FRMD6, CPSF1, or SMTN, among others. Expression of HLA A and B is associated with T cell activation and identifies immune activated, basal-lik …
Several neopeptides expressed in breast cancer were also identified including FUK, SNAPC3, GC, ANO8, DOT1L, HIST1H3F, MYBPH, STX2, FR …
Anoctamin 8 tethers endoplasmic reticulum and plasma membrane for assembly of Ca2+ signaling complexes at the ER/PM compartment.
Jha A, Chung WY, Vachel L, Maleth J, Lake S, Zhang G, Ahuja M, Muallem S. Jha A, et al. EMBO J. 2019 Jun 17;38(12):e101452. doi: 10.15252/embj.2018101452. Epub 2019 May 6. EMBO J. 2019. PMID: 31061173 Free PMC article.
MCSs are formed by tether proteins that bridge the opposing membranes, but the identity and role of these tethers in receptor-evoked Ca(2+) signaling is not well understood. Here, we identified Anoctamin 8 (ANO8) as a key tether in the formation of the ER/PM junctions that …
MCSs are formed by tether proteins that bridge the opposing membranes, but the identity and role of these tethers in receptor-evoked Ca(2+) …
Exosomal miRNA Changes Associated with Restoration to Sinus Rhythm in Atrial Fibrillation Patients.
Tsai PC, Ko AM, Chen YL, Chiu CH, Yeh YH, Tsai FC. Tsai PC, et al. Int J Mol Sci. 2024 Mar 29;25(7):3861. doi: 10.3390/ijms25073861. Int J Mol Sci. 2024. PMID: 38612670 Free PMC article.
In addition, the reads were mapped to mRNA sequences, leading to the identification of 14 mRNAs (AC005041.1, ARHGEF12, AMT, ANO8, BCL11A, DIO3OS, EIF4ENIF1, G2E3-AS1, HERC3, LARS, NT5E, PITX1, SLC16A12, and ZBTB21) associated with restoration to SR. ...
In addition, the reads were mapped to mRNA sequences, leading to the identification of 14 mRNAs (AC005041.1, ARHGEF12, AMT, ANO8, BCL …
Targeting of Intracellular TMEM16 Proteins to the Plasma Membrane and Activation by Purinergic Signaling.
Schreiber R, Ousingsawat J, Kunzelmann K. Schreiber R, et al. Int J Mol Sci. 2020 Jun 5;21(11):4065. doi: 10.3390/ijms21114065. Int J Mol Sci. 2020. PMID: 32517157 Free PMC article.
Here, we report that TMEM16E (ANO5), -H (ANO8), -J (ANO9) and K (ANO10) are targeted to the plasma membrane when fused to a C-terminal CAAX (cysteine, two aliphatic amino acids plus methionin, serine, alanin, cystein or glutamin) motif. ...
Here, we report that TMEM16E (ANO5), -H (ANO8), -J (ANO9) and K (ANO10) are targeted to the plasma membrane when fused to a C-termina …
Anoctamins are a family of Ca2+-activated Cl- channels.
Tian Y, Schreiber R, Kunzelmann K. Tian Y, et al. J Cell Sci. 2012 Nov 1;125(Pt 21):4991-8. doi: 10.1242/jcs.109553. Epub 2012 Sep 3. J Cell Sci. 2012. PMID: 22946059
Although some anoctamins (Ano1, 2, 4, 6, 7) were found to be well expressed in the plasma membrane, others (Ano8, 9, 10) show rather poor membrane expression and were mostly retained in the cytosol. ...
Although some anoctamins (Ano1, 2, 4, 6, 7) were found to be well expressed in the plasma membrane, others (Ano8, 9, 10) show rather …
17 results