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The following term was not found in PubMed: shakibaeinezhad
Page 1
T cell activation.
Smith-Garvin JE, Koretzky GA, Jordan MS. Smith-Garvin JE, et al. Annu Rev Immunol. 2009;27:591-619. doi: 10.1146/annurev.immunol.021908.132706. Annu Rev Immunol. 2009. PMID: 19132916 Free PMC article. Review.
This review continues with a description of the current state of our understanding of TCR signaling, as well as a summary of recent findings examining other key aspects of T cell activation, including cross talk between the TCR and integrins, the role of costimulatory mole …
This review continues with a description of the current state of our understanding of TCR signaling, as well as a summary of recent findings …
Role of platelets and platelet receptors in cancer metastasis.
Schlesinger M. Schlesinger M. J Hematol Oncol. 2018 Oct 11;11(1):125. doi: 10.1186/s13045-018-0669-2. J Hematol Oncol. 2018. PMID: 30305116 Free PMC article. Review.
This review provides a synopsis on the current literature on platelet-mediated effects in cancer metastasis and particularly focuses on platelet adhesion receptors and their role in metastasis. Immunoreceptor tyrosine-based activation motif (ITA …
This review provides a synopsis on the current literature on platelet-mediated effects in cancer metastasis and particularly focuses on plat …
Platelet activation and signaling in thrombus formation.
Swieringa F, Heemskerk JWM, Assinger A. Swieringa F, et al. Blood. 2025 Sep 18;146(12):1400-1411. doi: 10.1182/blood.2024025320. Blood. 2025. PMID: 39869836 Review.
We discuss pathways involved in platelet adhesion, shape change, integrin activation, intracellular vesicle trafficking and protein processing, granule secretion, aggregate formation, and procoagulant activity. Specific attention is paid to the signaling routes used by …
We discuss pathways involved in platelet adhesion, shape change, integrin activation, intracellular vesicle trafficking and protein p …
Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency.
Feucht J, Sun J, Eyquem J, Ho YJ, Zhao Z, Leibold J, Dobrin A, Cabriolu A, Hamieh M, Sadelain M. Feucht J, et al. Nat Med. 2019 Jan;25(1):82-88. doi: 10.1038/s41591-018-0290-5. Epub 2018 Dec 17. Nat Med. 2019. PMID: 30559421 Free PMC article.
Thus, we hypothesized that calibrating the activation potential of CD28-based CARs would differentially reprogram T cell function and differentiation. Here, we show that CARs encoding a single immunoreceptor tyrosine-based activation motif …
Thus, we hypothesized that calibrating the activation potential of CD28-based CARs would differentially reprogram T cell function and …
A key role for platelet GPVI in neutrophil recruitment, migration, and NETosis in the early stages of acute lung injury.
Burkard P, Schonhart C, Vögtle T, Köhler D, Tang L, Johnson D, Hemmen K, Heinze KG, Zarbock A, Hermanns HM, Rosenberger P, Nieswandt B. Burkard P, et al. Blood. 2023 Oct 26;142(17):1463-1477. doi: 10.1182/blood.2023019940. Blood. 2023. PMID: 37441848 Free article.
Platelets have been implicated in the pathogenesis of ALI/ARDS, but the underlying mechanisms are not fully understood. Here, we show that the immunoreceptor tyrosine-based activation motif-coupled immunoglobulin-like platelet receptor, glycopro …
Platelets have been implicated in the pathogenesis of ALI/ARDS, but the underlying mechanisms are not fully understood. Here, we show that t …
Platelet ITAM signaling.
Bergmeier W, Stefanini L. Bergmeier W, et al. Curr Opin Hematol. 2013 Sep;20(5):445-50. doi: 10.1097/MOH.0b013e3283642267. Curr Opin Hematol. 2013. PMID: 23921514 Review.
PURPOSE OF REVIEW: G protein-coupled receptors (GPCRs) like PAR1/4 and P2Y12 have long been known for their critical role in hemostasis. In contrast, deficiency in the immunoreceptor tyrosine-based activation motif (ITAM)-coupled receptors glyco …
PURPOSE OF REVIEW: G protein-coupled receptors (GPCRs) like PAR1/4 and P2Y12 have long been known for their critical role in hemostasis. In …
The TREM-1/DAP12 pathway.
Tessarz AS, Cerwenka A. Tessarz AS, et al. Immunol Lett. 2008 Mar 15;116(2):111-6. doi: 10.1016/j.imlet.2007.11.021. Epub 2007 Dec 26. Immunol Lett. 2008. PMID: 18192027 Review.
DNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing adapter, which couples to multiple receptors expressed on natural killer (NK) cells, monocytes, and neutrophils. ...
DNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITA …
Chimeric antigen receptor with novel intracellular modules improves antitumor performance of T cells.
Wang P, Wang Y, Zhao X, Zheng R, Zhang Y, Meng R, Dong H, Liang S, He X, Song Y, Su H, Yan B, Yang AG, Jia L. Wang P, et al. Signal Transduct Target Ther. 2025 Jan 15;10(1):20. doi: 10.1038/s41392-024-02096-5. Signal Transduct Target Ther. 2025. PMID: 39809749 Free PMC article.
Here, we obtained a series of CAR-T cells against HER2 and mesothelin using a domain comprising a single immunoreceptor tyrosine-based activation motif from different CD3 subunits as the ICD of CARs. ...
Here, we obtained a series of CAR-T cells against HER2 and mesothelin using a domain comprising a single immunoreceptor tyrosine …
Molecular mechanisms of immunoreceptors in platelets.
Kuriri FA, O'Malley CJ, Jackson DE. Kuriri FA, et al. Thromb Res. 2019 Apr;176:108-114. doi: 10.1016/j.thromres.2019.01.019. Epub 2019 Feb 10. Thromb Res. 2019. PMID: 30802692 Review.
Naturally, bioactive mediators are released from endothelial cells to prevent and control platelet activation. However, when the vascular endothelium is ruptured, the local concentration of nitric oxide and prostaglandin is diminished and receptors containing a sequence of …
Naturally, bioactive mediators are released from endothelial cells to prevent and control platelet activation. However, when the vasc …
Siglec functions of microglia.
Linnartz-Gerlach B, Kopatz J, Neumann H. Linnartz-Gerlach B, et al. Glycobiology. 2014 Sep;24(9):794-9. doi: 10.1093/glycob/cwu044. Epub 2014 May 15. Glycobiology. 2014. PMID: 24833613 Review.
Therefore, microglia need recognition receptors that lead to either the activation or the inhibition of the immune response pathways. Most Siglecs contain an immunoreceptor tyrosine based inhibition motif and its signaling leads to the terminati …
Therefore, microglia need recognition receptors that lead to either the activation or the inhibition of the immune response pathways. …
1,649 results