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1983 1
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119 results

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Page 1
Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.
Cui Z, Napolitano G, de Araujo MEG, Esposito A, Monfregola J, Huber LA, Ballabio A, Hurley JH. Cui Z, et al. Among authors: de araujo meg. Nature. 2023 Feb;614(7948):572-579. doi: 10.1038/s41586-022-05652-7. Epub 2023 Jan 25. Nature. 2023. PMID: 36697823 Free PMC article.
A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dubé syndrome.
Napolitano G, Di Malta C, Esposito A, de Araujo MEG, Pece S, Bertalot G, Matarese M, Benedetti V, Zampelli A, Stasyk T, Siciliano D, Venuta A, Cesana M, Vilardo C, Nusco E, Monfregola J, Calcagnì A, Di Fiore PP, Huber LA, Ballabio A. Napolitano G, et al. Among authors: de araujo meg. Nature. 2020 Sep;585(7826):597-602. doi: 10.1038/s41586-020-2444-0. Epub 2020 Jul 1. Nature. 2020. PMID: 32612235 Free PMC article.
G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling.
Prentzell MT, Rehbein U, Cadena Sandoval M, De Meulemeester AS, Baumeister R, Brohée L, Berdel B, Bockwoldt M, Carroll B, Chowdhury SR, von Deimling A, Demetriades C, Figlia G; Genomics England Research Consortium; de Araujo MEG, Heberle AM, Heiland I, Holzwarth B, Huber LA, Jaworski J, Kedra M, Kern K, Kopach A, Korolchuk VI, van 't Land-Kuper I, Macias M, Nellist M, Palm W, Pusch S, Ramos Pittol JM, Reil M, Reintjes A, Reuter F, Sampson JR, Scheldeman C, Siekierska A, Stefan E, Teleman AA, Thomas LE, Torres-Quesada O, Trump S, West HD, de Witte P, Woltering S, Yordanov TE, Zmorzynska J, Opitz CA, Thedieck K. Prentzell MT, et al. Among authors: de araujo meg. Cell. 2021 Feb 4;184(3):655-674.e27. doi: 10.1016/j.cell.2020.12.024. Epub 2021 Jan 25. Cell. 2021. PMID: 33497611 Free PMC article.
Lysosomal size matters.
de Araujo MEG, Liebscher G, Hess MW, Huber LA. de Araujo MEG, et al. Traffic. 2020 Jan;21(1):60-75. doi: 10.1111/tra.12714. Epub 2019 Dec 6. Traffic. 2020. PMID: 31808235 Free PMC article. Review.
TXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescence.
Kahlhofer J, Marchet N, Zubak K, Seifert B, Hotze M, Egger-Hörschinger AS, Kucej L, Manzl C, Weyer Y, Weys S, Offterdinger M, Herzog S, Reiterer V, Volani C, Kwiatkowski M, Wortmann SB, Nemati S, Mayr JA, Zschocke J, Radlinger B, Thedieck K, Kremser L, Sarg B, Huber LA, Farhan H, de Araujo MEG, Kaser S, Scholl-Bürgi S, Karall D, Teis D. Kahlhofer J, et al. Among authors: de araujo meg. EMBO J. 2025 Dec;44(23):7119-7153. doi: 10.1038/s44318-025-00608-9. Epub 2025 Oct 20. EMBO J. 2025. PMID: 41116060 Free PMC article.
Truncated variants of MAGEL2 are involved in the etiologies of the Schaaf-Yang and Prader-Willi syndromes.
Heimdörfer D, Vorleuter A, Eschlböck A, Spathopoulou A, Suarez-Cubero M, Farhan H, Reiterer V, Spanjaard M, Schaaf CP, Huber LA, Kremser L, Sarg B, Edenhofer F, Geley S, de Araujo MEG, Huettenhofer A. Heimdörfer D, et al. Among authors: de araujo meg. Am J Hum Genet. 2024 Jul 11;111(7):1383-1404. doi: 10.1016/j.ajhg.2024.05.023. Epub 2024 Jun 21. Am J Hum Genet. 2024. PMID: 38908375 Free PMC article.
Subcellular fractionation.
de Araújo ME, Huber LA. de Araújo ME, et al. Methods Mol Biol. 2007;357:73-85. doi: 10.1385/1-59745-214-9:73. Methods Mol Biol. 2007. PMID: 17172680
Truncated variants of MAGEL2 are involved in the etiologies of the Schaaf-Yang and Prader-Willi syndromes.
Heimdörfer D, Vorleuter A, Eschlböck A, Spathopoulou A, Suarez-Cubero M, Farhan H, Reiterer V, Spanjaard M, Schaaf CP, Huber LA, Kremser L, Sarg B, Edenhofer F, Geley S, de Araujo MEG, Huettenhofer A. Heimdörfer D, et al. Among authors: de araujo meg. Am J Hum Genet. 2025 Oct 2;112(10):2562. doi: 10.1016/j.ajhg.2025.09.005. Epub 2025 Sep 12. Am J Hum Genet. 2025. PMID: 40945516 Free PMC article. No abstract available.
Lysosomal phosphoinositide turnover acts upstream of RagGTPase-mTORC1 and controls muscle growth.
Picot M, Hifdi N, Vaucourt M, Mansat M, Li P, Singer I, Chicanne G, Stella A, Kuang S, Miceli C, Henneman NF, Payrastre B, Vandromme M, Schiltz O, Nemazanyy I, de Araujo MEG, Panasyuk G, Viaud J, Lämmerhofer M, Hnia K. Picot M, et al. Among authors: de araujo meg. Nat Metab. 2026 Mar;8(3):624-645. doi: 10.1038/s42255-026-01484-1. Epub 2026 Mar 18. Nat Metab. 2026. PMID: 41851531 Free PMC article.
BORC assemblies integrate BLOC-1 subunits to diversify endosomal trafficking functions.
de Araujo MEG, J Amann S, Stasyk T, Schleiffer A, Rauch E, Flümann P, Singer II, Kremser L, Dostal V, Laopanupong T, Obojes N, Wallnöfer MH, Gradl FS, Kurzbauer R, Krebiehl C, Kofler S, Grishkovskaya I, Vogel GF, Hess MW, Sarg B, Clausen T, Haselbach D, Huber LA. de Araujo MEG, et al. Proc Natl Acad Sci U S A. 2026 Jan 27;123(4):e2515691123. doi: 10.1073/pnas.2515691123. Epub 2026 Jan 20. Proc Natl Acad Sci U S A. 2026. PMID: 41557793 Free PMC article.
119 results