Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 1
2004 3
2005 1
2006 1
2007 1
2008 3
2009 2
2010 2
2011 1
2012 5
2013 2
2014 3
2015 3
2016 2
2017 7
2018 6
2019 5
2020 3
2021 6
2023 8
2024 6
2025 0

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

65 results

Results by year

Filters applied: . Clear all
Page 1
ARHGAP21 as a master regulator of multiple cellular processes.
Rosa LRO, Soares GM, Silveira LR, Boschero AC, Barbosa-Sampaio HCL. Rosa LRO, et al. J Cell Physiol. 2018 Nov;233(11):8477-8481. doi: 10.1002/jcp.26829. Epub 2018 Jun 1. J Cell Physiol. 2018. PMID: 29856495 Review.
In the past decade, one of those regulators, the RhoGAP Rho GTPase Activating Protein 21 (ARHGAP21), has been overlooked, despite being implied as having an important role on many of those processes. In this paper, we aimed to review the available literature regarding A …
In the past decade, one of those regulators, the RhoGAP Rho GTPase Activating Protein 21 (ARHGAP21), has been overlooked, despite bei …
ARHGAP21 Is Involved in the Carcinogenic Mechanism of Cholangiocarcinoma: A Study Based on Bioinformatic Analyses and Experimental Validation.
Wang Z, Wu S, Wang G, Yang Z, Zhang Y, Zhu C, Qin X. Wang Z, et al. Medicina (Kaunas). 2023 Jan 10;59(1):139. doi: 10.3390/medicina59010139. Medicina (Kaunas). 2023. PMID: 36676763 Free PMC article.
The ssGSEA algorithm was further used to explore the immune-related mechanism of ARHGAP21 in CCA. Results: The ARHGAP21 expression in CCA tissue was higher than it was in normal tissue, and missense mutation was the main alteration of ARHGAP21 in CCA. ...Conc …
The ssGSEA algorithm was further used to explore the immune-related mechanism of ARHGAP21 in CCA. Results: The ARHGAP21 expres …
ARHGAP21 Acts as an Inhibitor of the Glucose-Stimulated Insulin Secretion Process.
Ferreira SM, Costa-Júnior JM, Kurauti MA, Leite NC, Ortis F, Rezende LF, Barbosa HC, Boschero AC, Santos GJ. Ferreira SM, et al. Front Endocrinol (Lausanne). 2020 Nov 26;11:599165. doi: 10.3389/fendo.2020.599165. eCollection 2020. Front Endocrinol (Lausanne). 2020. PMID: 33324349 Free PMC article.
ARHGAP21 is a RhoGAP protein implicated in the modulation of insulin secretion and energy metabolism. ARHGAP21 transient-inhibition increase glucose-stimulated insulin secretion (GSIS) in neonatal islets; however, ARHGAP21 heterozygote mice have a reduced ins …
ARHGAP21 is a RhoGAP protein implicated in the modulation of insulin secretion and energy metabolism. ARHGAP21 transient-inhib …
Arhgap21 Deficiency Results in Increase of Osteoblastic Lineage Cells in the Murine Bone Marrow Microenvironment.
Pissarra MF, Torello CO, Gomes RGB, Shiraishi RN, Santos I, Vieira Ferro KP, Lopes MR, Bergamo Favaro PM, Olalla Saad ST, Lazarini M. Pissarra MF, et al. Front Cell Dev Biol. 2021 Nov 30;9:718560. doi: 10.3389/fcell.2021.718560. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34917608 Free PMC article.
ARHGAP21 is a member of the RhoGAP family of proteins involved in cell growth, differentiation, and adhesion. ...Arhgap21(+/-) BM cells had increased capacity of generating osteogenic colony-forming units (CFU-OB) in vitro and higher levels of osteocalcin were detec …
ARHGAP21 is a member of the RhoGAP family of proteins involved in cell growth, differentiation, and adhesion. ...Arhgap21(+/-) …
[ARHGAP21 inhibits epithelial-mesenchymal transition by inactivating the WNT signaling pathway in non-small cell lung cancer].
Xie Z, Liu L, Fang J, Zhong X, Lin J, Chen F. Xie Z, et al. Nan Fang Yi Ke Da Xue Xue Bao. 2023 Aug 20;43(8):1322-1332. doi: 10.12122/j.issn.1673-4254.2023.08.08. Nan Fang Yi Ke Da Xue Xue Bao. 2023. PMID: 37712268 Free PMC article. Chinese.
METHODS: TCGA, CPTAC database were used to analyze the correlation of ARHGAP21 expression level in NSCLC and the patients' prognosis. The expression of ARHGAP21 in clinical specimens of NSCLC tissues was examined using Western blotting and immunohistochemistry. ...R …
METHODS: TCGA, CPTAC database were used to analyze the correlation of ARHGAP21 expression level in NSCLC and the patients' prognosis. …
Whole-Body ARHGAP21-Deficiency Improves Energetic Homeostasis in Lean and Obese Mice.
Soares GM, Zangerolamo L, Costa-Júnior JM, Vettorazzi JF, Carneiro EM, Saad ST, Boschero AC, Barbosa-Sampaio HC. Soares GM, et al. Front Endocrinol (Lausanne). 2019 May 29;10:338. doi: 10.3389/fendo.2019.00338. eCollection 2019. Front Endocrinol (Lausanne). 2019. PMID: 31191459 Free PMC article.
Here, we assessed the possible involvement of GTPase activating protein 21 (ARHGAP21), a Rho-GAP protein, in energy homeostasis. Wild-type and whole-body ARHGAP21-haplodeficient mice were fed either chow or high-fat diet for 10 weeks. ...Our data suggest that the re …
Here, we assessed the possible involvement of GTPase activating protein 21 (ARHGAP21), a Rho-GAP protein, in energy homeostasis. Wild …
ARHGAP21 deficiency impairs hepatic lipid metabolism and improves insulin signaling in lean and obese mice.
Zangerolamo L, Soares GM, Vettorazzi JF, do Amaral ME, Carneiro EM, Olalla-Saad ST, Boschero AC, Barbosa-Sampaio HC. Zangerolamo L, et al. Can J Physiol Pharmacol. 2019 Nov;97(11):1018-1027. doi: 10.1139/cjpp-2018-0691. Epub 2019 Jun 27. Can J Physiol Pharmacol. 2019. PMID: 31247150
ARHGAP21 is a Rho-GAP that controls GTPases activity in several tissues, but its role on liver lipid metabolism is unknown. ...In conclusion, liver of ARHGAP21-haplodeficient mice are more insulin sensitive, associated with higher lipid synthesis and lower lipid exp …
ARHGAP21 is a Rho-GAP that controls GTPases activity in several tissues, but its role on liver lipid metabolism is unknown. ...In con …
A Structural Network Analysis of Neuronal ArhGAP21/23 Interactors by Computational Modeling.
Kouchi Z, Kojima M. Kouchi Z, et al. ACS Omega. 2023 May 23;8(22):19249-19264. doi: 10.1021/acsomega.2c08054. eCollection 2023 Jun 6. ACS Omega. 2023. PMID: 37305272 Free PMC article.
RhoGTPase-activating proteins (RhoGAPs) play multiple roles in neuronal development; however, details of their substrate recognition system remain elusive. ArhGAP21 and ArhGAP23 are RhoGAPs that contain N-terminal PDZ and pleckstrin homology domains. ...The pleckstrin homo …
RhoGTPase-activating proteins (RhoGAPs) play multiple roles in neuronal development; however, details of their substrate recognition system …
ARHGAP21 prevents abnormal insulin release through actin rearrangement in pancreatic islets from neonatal mice.
Ferreira SM, Santos GJ, Rezende LF, Gonçalves LM, Santos-Silva JC, Bigarella CL, Carneiro EM, Saad ST, Boschero AC, Barbosa-Sampaio HC. Ferreira SM, et al. Life Sci. 2015 Apr 15;127:53-8. doi: 10.1016/j.lfs.2015.01.041. Epub 2015 Mar 2. Life Sci. 2015. PMID: 25744409
However, it is unknown whether ARHGAP21 is expressed in pancreatic beta cells and its function in these cells. Herein, we assess the participation of ARHGAP21 in insulin secretion. ...SIGNIFICANCE: In conclusion, our data show, for the first time, that ARHGAP21 …
However, it is unknown whether ARHGAP21 is expressed in pancreatic beta cells and its function in these cells. Herein, we assess the …
ARHGAP21 modulates FAK activity and impairs glioblastoma cell migration.
Bigarella CL, Borges L, Costa FF, Saad ST. Bigarella CL, et al. Biochim Biophys Acta. 2009 May;1793(5):806-16. doi: 10.1016/j.bbamcr.2009.02.010. Epub 2009 Mar 4. Biochim Biophys Acta. 2009. PMID: 19268501 Free article.
In the present work, we demonstrate that the RhoGTPase Activating Protein 21 (ARHGAP21) is expressed in the nuclear and perinuclear regions of several cell lines. In T98G and U138MG, glioblastoma derived cell lines, ARHGAP21 interacts with the C-terminal region of F …
In the present work, we demonstrate that the RhoGTPase Activating Protein 21 (ARHGAP21) is expressed in the nuclear and perinuclear r …
65 results