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213 results

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Page 1
The Role of ARID5B in Acute Lymphoblastic Leukemia and Beyond.
Wang P, Deng Y, Yan X, Zhu J, Yin Y, Shu Y, Bai D, Zhang S, Xu H, Lu X. Wang P, et al. Front Genet. 2020 Jun 12;11:598. doi: 10.3389/fgene.2020.00598. eCollection 2020. Front Genet. 2020. PMID: 32595701 Free PMC article. Review.
As indicated by several genome wide association studies (GWASs) and candidate gene analyses, ARID5B, a member of AT-rich interactive domain (ARID) protein family, is associated with the occurrence and prognosis of ALL. However, the mechanisms by which ARID5B genotyp …
As indicated by several genome wide association studies (GWASs) and candidate gene analyses, ARID5B, a member of AT-rich interactive …
Integrated genomic characterization of endometrial carcinoma.
Cancer Genome Atlas Research Network; Kandoth C, Schultz N, Cherniack AD, Akbani R, Liu Y, Shen H, Robertson AG, Pashtan I, Shen R, Benz CC, Yau C, Laird PW, Ding L, Zhang W, Mills GB, Kucherlapati R, Mardis ER, Levine DA. Cancer Genome Atlas Research Network, et al. Nature. 2013 May 2;497(7447):67-73. doi: 10.1038/nature12113. Nature. 2013. PMID: 23636398 Free PMC article.
Most endometrioid tumours had few copy number alterations or TP53 mutations, but frequent mutations in PTEN, CTNNB1, PIK3CA, ARID1A and KRAS and novel mutations in the SWI/SNF chromatin remodelling complex gene ARID5B. A subset of endometrioid tumours that we identified ha …
Most endometrioid tumours had few copy number alterations or TP53 mutations, but frequent mutations in PTEN, CTNNB1, PIK3CA, ARID1A and KRAS …
ARID5B influences B-cell development and function in mouse.
Goodings C, Zhao X, McKinney-Freeman S, Zhang H, Yang JJ. Goodings C, et al. Haematologica. 2023 Feb 1;108(2):502-512. doi: 10.3324/haematol.2022.281157. Haematologica. 2023. PMID: 35924577 Free PMC article.
Genomewide association studies by us and others have identified non-coding acute lymphoblastic leukemia risk variants at the ARID5B gene locus, but the molecular mechanisms linking ARID5B to normal and malignant hematopoiesis remain largely unknown. ...Taken togethe …
Genomewide association studies by us and others have identified non-coding acute lymphoblastic leukemia risk variants at the ARID5B g …
ARID5B gene polymorphisms and the risk of childhood acute lymphoblastic leukemia: a meta-analysis.
Yang JL, Liu YN, Bi YY, Wang H. Yang JL, et al. Int J Hematol. 2019 Sep;110(3):272-284. doi: 10.1007/s12185-019-02658-2. Epub 2019 May 20. Int J Hematol. 2019. PMID: 31111395
Genome-wide association studies have implicated several single-nucleotide polymorphisms (SNPs) in the AT-rich interactive domain 5B (ARID5B) gene in children with ALL; however, whether ARID5B variants (rs10821936, rs10994982, rs7089424) are associated with childhood …
Genome-wide association studies have implicated several single-nucleotide polymorphisms (SNPs) in the AT-rich interactive domain 5B (ARID …
Molecular Mechanisms of ARID5B-Mediated Genetic Susceptibility to Acute Lymphoblastic Leukemia.
Zhao X, Qian M, Goodings C, Zhang Y, Yang W, Wang P, Xu B, Tian C, Pui CH, Hunger SP, Raetz EA, Devidas M, Relling MV, Loh ML, Savic D, Li C, Yang JJ. Zhao X, et al. J Natl Cancer Inst. 2022 Sep 9;114(9):1287-1295. doi: 10.1093/jnci/djac101. J Natl Cancer Inst. 2022. PMID: 35575404 Free PMC article.
Genome-wide association studies have identified non-coding ALL risk variants at the ARID5B gene locus, but their exact functional effects and the molecular mechanism linking ARID5B to B-cell ALL leukemogenesis remain largely unknown. ...ARID5B variant associa …
Genome-wide association studies have identified non-coding ALL risk variants at the ARID5B gene locus, but their exact functional eff …
ARID5B is a negative modulator of IL-6 production in rheumatoid arthritis synovial fibroblasts.
Tagawa Y, Saito T, Iwai H, Sato M, Noda S, Yamamoto A, Ota M, Endo K, Koga H, Takahara Y, Sugimoto K, Sekiya I, Fujio K, Kawakami E, Mizoguchi F, Yasuda S. Tagawa Y, et al. Immunol Med. 2024 Sep;47(3):176-185. doi: 10.1080/25785826.2024.2346956. Epub 2024 May 15. Immunol Med. 2024. PMID: 38747454 Free article.
The siRNA screening identified 7 TFs including ARID5B, a RA risk gene, that affected IL-6 production. Both long and short isoforms of ARID5B were expressed and negatively regulated by TNF-alpha in RASFs. ...ARID5B was found to be a negative modulator of IL-6 …
The siRNA screening identified 7 TFs including ARID5B, a RA risk gene, that affected IL-6 production. Both long and short isoforms of …
ARID5B regulates fatty acid metabolism and proliferation at the Pre-B cell stage during B cell development.
Chalise JP, Ehsani A, Lemecha M, Hung YW, Zhang G, Larson GP, Itakura K. Chalise JP, et al. Front Immunol. 2023 Jul 7;14:1170475. doi: 10.3389/fimmu.2023.1170475. eCollection 2023. Front Immunol. 2023. PMID: 37483604 Free PMC article.
Arid5b inhibition ex vivo also led to an increase in proliferation of both Pre-B cell populations. ...Collectively, our data indicated that Arid5b regulates fatty acid metabolism and proliferation of Pre-B cells in mice, and reduced expression of ARID5B in hu …
Arid5b inhibition ex vivo also led to an increase in proliferation of both Pre-B cell populations. ...Collectively, our data indicate …
ARID5B-mediated LINC01128 epigenetically activated pyroptosis and apoptosis by promoting the formation of the BTF3/STAT3 complex in beta2GPI/anti-beta2GPI-treated monocytes.
Tan Y, Qiao J, Yang S, Wang Q, Liu H, Liu Q, Feng W, Yang B, Li Z, Cui L. Tan Y, et al. Clin Transl Med. 2024 Jan;14(1):e1539. doi: 10.1002/ctm2.1539. Clin Transl Med. 2024. PMID: 38224186 Free PMC article.
RESULTS: H3K4me3 signal and open chromatin at the ARID5B promoter were increased in an in vitro model of APS. The epigenetic factor ARID5B directly activated LINC01128 transcription at its promoter. ...HIGHLIGHTS: The H3K4me3 mark and chromatin accessibility at the …
RESULTS: H3K4me3 signal and open chromatin at the ARID5B promoter were increased in an in vitro model of APS. The epigenetic factor …
ARID5B Influences Antimetabolite Drug Sensitivity and Prognosis of Acute Lymphoblastic Leukemia.
Xu H, Zhao X, Bhojwani D, E S, Goodings C, Zhang H, Seibel NL, Yang W, Li C, Carroll WL, Evans WE, Yang JJ. Xu H, et al. Clin Cancer Res. 2020 Jan 1;26(1):256-264. doi: 10.1158/1078-0432.CCR-19-0190. Epub 2019 Oct 1. Clin Cancer Res. 2020. PMID: 31573954 Free PMC article.
Recently, we and others have identified genetic variants in the ARID5B gene associated with susceptibility to ALL and also with relapse. In this study, we sought to characterize the molecular pathway by which ARID5B affects antileukemic drug response in patients wit …
Recently, we and others have identified genetic variants in the ARID5B gene associated with susceptibility to ALL and also with relap …
Human papillomavirus-independent cervical cancer.
Fernandes A, Viveros-Carreño D, Hoegl J, Ávila M, Pareja R. Fernandes A, et al. Int J Gynecol Cancer. 2022 Jan;32(1):1-7. doi: 10.1136/ijgc-2021-003014. Epub 2021 Nov 1. Int J Gynecol Cancer. 2022. PMID: 34725203 Free article.
The HPV-independent tumors are characterized by a differentiated molecular profile with lower proliferative activity, a p53 immunostaining, a decreased expression of cyclin-dependent kinase inhibitor proteins, such as p16, p14, and p27, and alterations in PTEN, p53, KRAS, CTNNB1, …
The HPV-independent tumors are characterized by a differentiated molecular profile with lower proliferative activity, a p53 immunostaining, …
213 results