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cAMP and Epac in the regulation of tissue fibrosis.

Insel PA, Murray F, Yokoyama U, Romano S, Yun H, Brown L, Snead A, Lu D, Aroonsakool N. Insel PA, et al. Among authors: aroonsakool n. Br J Pharmacol. 2012 May;166(2):447-56. doi: 10.1111/j.1476-5381.2012.01847.x. Br J Pharmacol. 2012. PMID: 22233238 Free PMC article. Review.

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G Protein-Coupled Receptor (GPCR) Expression in Native Cells: "Novel" endoGPCRs as Physiologic Regulators and Therapeutic Targets.

Insel PA, Wilderman A, Zambon AC, Snead AN, Murray F, Aroonsakool N, McDonald DS, Zhou S, McCann T, Zhang L, Sriram K, Chinn AM, Michkov AV, Lynch RM, Overland AC, Corriden R. Insel PA, et al. Among authors: aroonsakool n. Mol Pharmacol. 2015 Jul;88(1):181-7. doi: 10.1124/mol.115.098129. Epub 2015 Mar 3. Mol Pharmacol. 2015. PMID: 25737495 Free PMC article. Review.

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Role for high-glucose-induced protein O-GlcNAcylation in stimulating cardiac fibroblast collagen synthesis.

Aguilar H, Fricovsky E, Ihm S, Schimke M, Maya-Ramos L, Aroonsakool N, Ceballos G, Dillmann W, Villarreal F, Ramirez-Sanchez I. Aguilar H, et al. Among authors: aroonsakool n. Am J Physiol Cell Physiol. 2014 May 1;306(9):C794-804. doi: 10.1152/ajpcell.00251.2013. Epub 2014 Feb 19. Am J Physiol Cell Physiol. 2014. PMID: 24553187 Free PMC article.

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Allosteric inhibition of Epac: computational modeling and experimental validation to identify allosteric sites and inhibitors.

Brown LM, Rogers KE, Aroonsakool N, McCammon JA, Insel PA. Brown LM, et al. Among authors: aroonsakool n. J Biol Chem. 2014 Oct 17;289(42):29148-57. doi: 10.1074/jbc.M114.569319. Epub 2014 Sep 2. J Biol Chem. 2014. PMID: 25183009 Free PMC article.

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The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals.

Yokoyama U, Patel HH, Lai NC, Aroonsakool N, Roth DM, Insel PA. Yokoyama U, et al. Among authors: aroonsakool n. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6386-91. doi: 10.1073/pnas.0801490105. Epub 2008 Apr 23. Proc Natl Acad Sci U S A. 2008. PMID: 18434542 Free PMC article.

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An analysis of the effects of stretch on IGF-I secretion from rat ventricular fibroblasts.

Hu BS, Landeen LK, Aroonsakool N, Giles WR. Hu BS, et al. Among authors: aroonsakool n. Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H677-83. doi: 10.1152/ajpheart.01413.2006. Epub 2007 Mar 30. Am J Physiol Heart Circ Physiol. 2007. PMID: 17400715 Free article.

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Uridine triphosphate (UTP) induces profibrotic responses in cardiac fibroblasts by activation of P2Y2 receptors.

Braun OO, Lu D, Aroonsakool N, Insel PA. Braun OO, et al. Among authors: aroonsakool n. J Mol Cell Cardiol. 2010 Sep;49(3):362-9. doi: 10.1016/j.yjmcc.2010.05.001. Epub 2010 May 13. J Mol Cell Cardiol. 2010. PMID: 20471392 Free PMC article.

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Sphingosine-1-phosphate receptor expression in cardiac fibroblasts is modulated by in vitro culture conditions.

Landeen LK, Aroonsakool N, Haga JH, Hu BS, Giles WR. Landeen LK, et al. Among authors: aroonsakool n. Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2698-711. doi: 10.1152/ajpheart.01065.2006. Epub 2007 Mar 2. Am J Physiol Heart Circ Physiol. 2007. PMID: 17337593 Free article.

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Mechanisms of the negative inotropic effects of sphingosine-1-phosphate on adult mouse ventricular myocytes.

Landeen LK, Dederko DA, Kondo CS, Hu BS, Aroonsakool N, Haga JH, Giles WR. Landeen LK, et al. Among authors: aroonsakool n. Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H736-49. doi: 10.1152/ajpheart.00316.2007. Epub 2007 Nov 16. Am J Physiol Heart Circ Physiol. 2008. PMID: 18024550 Free article.

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Increase in cellular cyclic AMP concentrations reverses the profibrogenic phenotype of cardiac myofibroblasts: a novel therapeutic approach for cardiac fibrosis.

Lu D, Aroonsakool N, Yokoyama U, Patel HH, Insel PA. Lu D, et al. Among authors: aroonsakool n. Mol Pharmacol. 2013 Dec;84(6):787-93. doi: 10.1124/mol.113.087742. Epub 2013 Oct 1. Mol Pharmacol. 2013. PMID: 24085841 Free PMC article.

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