Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 1
2004 4
2007 1
2008 5
2009 3
2010 6
2011 1
2012 2
2013 4
2014 7
2015 7
2016 3
2017 8
2018 4
2019 5
2020 6
2021 9
2022 12
2023 7
2024 11
2025 6
2026 9

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

112 results

Results by year

Filters applied: . Clear all
Page 1
ARPC2 promotes breast cancer proliferation and metastasis.
Cheng Z, Wei W, Wu Z, Wang J, Ding X, Sheng Y, Han Y, Wu Q. Cheng Z, et al. Oncol Rep. 2019 Jun;41(6):3189-3200. doi: 10.3892/or.2019.7113. Epub 2019 Apr 12. Oncol Rep. 2019. PMID: 31002363 Free PMC article.
We performed siRNA-ARPC2 transfection to investigate the effect of ARPC2 on the proliferation, migration, invasion and arrest of BrCa cells. ...These results collectively indicated that ARPC2 promoted the tumorigenesis of breast carcinoma and the initiation o …
We performed siRNA-ARPC2 transfection to investigate the effect of ARPC2 on the proliferation, migration, invasion and arrest …
Arpc2 integrates ecdysone and juvenile hormone metabolism to influence metamorphosis and reproduction in Tribolium castaneum.
Ge R, Zhang L, Yang Y, Chen K, Li C. Ge R, et al. Pest Manag Sci. 2024 Aug;80(8):3734-3742. doi: 10.1002/ps.8076. Epub 2024 Mar 22. Pest Manag Sci. 2024. PMID: 38477435
However, the function and evolutionary relationship of this complex subunit 2 (Arpc2) has been poorly understood in insects. RESULTS: To address these issues, we performed comprehensive analysis of Arpc2 in Tribolium castaneum. ...T. castaneum Arpc2 has a 906 …
However, the function and evolutionary relationship of this complex subunit 2 (Arpc2) has been poorly understood in insects. RESULTS: …
ARPC2: A Pan-Cancer Prognostic and Immunological Biomarker That Promotes Hepatocellular Carcinoma Cell Proliferation and Invasion.
Huang S, Dong C, Li D, Xu Y, Wu J. Huang S, et al. Front Cell Dev Biol. 2022 Jun 6;10:896080. doi: 10.3389/fcell.2022.896080. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35733852 Free PMC article.
The Human Protein Atlas was used for the tissue/cell-specific expression analysis of ARPC2. The genetic alteration information of ARPC2 was obtained from the cBioPortal database and the GSCALite platform. ...Functionally, ARPC2 silencing in HCC cells signific …
The Human Protein Atlas was used for the tissue/cell-specific expression analysis of ARPC2. The genetic alteration information of …
Benproperine, an ARPC2 inhibitor, suppresses cancer cell migration and tumor metastasis.
Yoon YJ, Han YM, Choi J, Lee YJ, Yun J, Lee SK, Lee CW, Kang JS, Chi SW, Moon JH, Lee S, Han DC, Kwon BM. Yoon YJ, et al. Biochem Pharmacol. 2019 May;163:46-59. doi: 10.1016/j.bcp.2019.01.017. Epub 2019 Jan 30. Biochem Pharmacol. 2019. PMID: 30710516
Actin-related protein 2/3 complex subunit 2 (ARPC2) was identified as a molecular target of Benp by affinity column chromatography with Benp-tagged Sepharose beads. ...Therefore, ARPC2 is a potential target for anti-metastatic therapy, and Benp has the clinical pote …
Actin-related protein 2/3 complex subunit 2 (ARPC2) was identified as a molecular target of Benp by affinity column chromatography wi …
Role of ARPC2 in Human Gastric Cancer.
Zhang J, Liu Y, Yu CJ, Dai F, Xiong J, Li HJ, Wu ZS, Ding R, Wang H. Zhang J, et al. Mediators Inflamm. 2017;2017:5432818. doi: 10.1155/2017/5432818. Epub 2017 Jun 13. Mediators Inflamm. 2017. PMID: 28694563 Free PMC article.
For downstream pathways, CTNND1, EZH2, BCL2L2, CDH2, VIM, and EGFR were upregulated by ARPC2, whereas PTEN, BAK, and CDH1 were downregulated by ARPC2. In a clinical study, we examined the expression of ARPC2 in 110 cases of normal human gastric tissues and 11 …
For downstream pathways, CTNND1, EZH2, BCL2L2, CDH2, VIM, and EGFR were upregulated by ARPC2, whereas PTEN, BAK, and CDH1 were downre …
Actin polymerization inhibition by targeting ARPC2 affects intestinal stem cell homeostasis.
Zhang R, Chen S, Yang Z, Zhang N, Guo K, Lv K, Zhou Z, Gao M, Hu X, Su Y, He J, Wang F. Zhang R, et al. Burns Trauma. 2023 Oct 16;11:tkad038. doi: 10.1093/burnst/tkad038. eCollection 2023. Burns Trauma. 2023. PMID: 37849945 Free PMC article.
Treatment with the newly identified actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor BPP led to a dose-dependent increase or inhibition of intestinal organoid growth in vitro and crypt cell proliferation in vivo. ...CONCLUSION: Our findings indicate that the r …
Treatment with the newly identified actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor BPP led to a dose-dependent increas …
KLF7-IT1-ARPC2 axis in macrophages orchestrates caspase-4-driven hypercoagulation in sepsis.
Wang X, Lu Y, Yuan C, Yang X. Wang X, et al. Biochem Biophys Res Commun. 2025 Dec 31;793:153015. doi: 10.1016/j.bbrc.2025.153015. Epub 2025 Nov 19. Biochem Biophys Res Commun. 2025. PMID: 41275797
Mechanistically, KLF7-IT1 stabilized actin-related protein 2/3 complex subunit 2 (ARPC2), a core subunit of the Arp2/3 complex essential for actin remodeling, thereby facilitating intracellular LPS internalization and downstream caspase-4 activation. Silencing ARPC2 …
Mechanistically, KLF7-IT1 stabilized actin-related protein 2/3 complex subunit 2 (ARPC2), a core subunit of the Arp2/3 complex essent …
S-Benproperine, an Active Stereoisomer of Benproperine, Suppresses Cancer Migration and Tumor Metastasis by Targeting ARPC2.
Jang HJ, Yoon YJ, Choi J, Lee YJ, Lee S, Cho W, Byun WG, Park SB, Han DC, Kwon BM. Jang HJ, et al. Pharmaceuticals (Basel). 2022 Nov 25;15(12):1462. doi: 10.3390/ph15121462. Pharmaceuticals (Basel). 2022. PMID: 36558913 Free PMC article.
In the mutant study with ARPC2(F225A) cells, S-Benp did not bind to ARPC2(F225A) according to CETSA and DARTS. Furthermore, we validated that S-Benp colocalized with ARPC2 in cancer cells and directly bound to ARPC2 in tumor tissues using Cy3-conjugate …
In the mutant study with ARPC2(F225A) cells, S-Benp did not bind to ARPC2(F225A) according to CETSA and DARTS. Furthermore, we …
ARPC2 Promotes Pulmonary Fibrosis by Regulating MRTFA Activity Independent of the Canonical ARP2/3 Complex.
Du EJ, Kim H, Bae SG, An S, Ryoo K. Du EJ, et al. Int J Mol Sci. 2026 Mar 17;27(6):2729. doi: 10.3390/ijms27062729. Int J Mol Sci. 2026. PMID: 41898590 Free PMC article.
Furthermore, ARPC2 appears to modulate the TGF-beta1-dependent formation of MRTFA/G-actin complexes. Finally, transcriptomic analysis of cells depleted of ARPC2, ACTR2, or MRTFA revealed that ARPC2 and MRTFA co-regulate a specific repertoire of fibrotic genes …
Furthermore, ARPC2 appears to modulate the TGF-beta1-dependent formation of MRTFA/G-actin complexes. Finally, transcriptomic analysis …
RBM3 upregulates ARPC2 by binding the 3'UTR and contributes to breast cancer progression.
Chen P, Yue X, Xiong H, Lu X, Ji Z. Chen P, et al. Int J Oncol. 2019 Apr;54(4):1387-1397. doi: 10.3892/ijo.2019.4698. Epub 2019 Jan 28. Int J Oncol. 2019. PMID: 30720048
In downstream pathway analysis, actin related protein 2/3 complex subunit 2 (ARPC2) was determined to be positively regulated by RBM3 through a post-transcriptional 3'UTR-binding manner. ARPC2 also played an oncogenic role and mediated the promoting role of RBM3 in …
In downstream pathway analysis, actin related protein 2/3 complex subunit 2 (ARPC2) was determined to be positively regulated by RBM3 …
112 results