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ASCC3 promotes the immunosuppression and progression of non-small cell lung cancer by impairing the type I interferon response via CAND1-mediated ubiquitination inhibition of STAT3.
Ao YQ, Gao J, Jin C, Wang S, Zhang LC, Deng J, Chen ZW, Wang HK, Jiang JH, Ding JY. Ao YQ, et al. J Immunother Cancer. 2023 Dec 26;11(12):e007766. doi: 10.1136/jitc-2023-007766. J Immunother Cancer. 2023. PMID: 38148115 Free PMC article.
RESULTS: ASCC3 was significantly upregulated in NSCLC and correlated with poor pathological characteristics and prognosis in patients with NSCLC. ...Furthermore, high expression of ASCC3 impaired the efficacy of anti-PD-1 therapy, and an anti-PD-1 antibody combined …
RESULTS: ASCC3 was significantly upregulated in NSCLC and correlated with poor pathological characteristics and prognosis in patients …
Translation stress and collided ribosomes are co-activators of cGAS.
Wan L, Juszkiewicz S, Blears D, Bajpe PK, Han Z, Faull P, Mitter R, Stewart A, Snijders AP, Hegde RS, Svejstrup JQ. Wan L, et al. Mol Cell. 2021 Jul 1;81(13):2808-2822.e10. doi: 10.1016/j.molcel.2021.05.018. Epub 2021 Jun 9. Mol Cell. 2021. PMID: 34111399 Free PMC article.
The ASC-1 Complex Disassembles Collided Ribosomes.
Juszkiewicz S, Speldewinde SH, Wan L, Svejstrup JQ, Hegde RS. Juszkiewicz S, et al. Mol Cell. 2020 Aug 20;79(4):603-614.e8. doi: 10.1016/j.molcel.2020.06.006. Epub 2020 Jun 23. Mol Cell. 2020. PMID: 32579943 Free PMC article.
The widely conserved ASC-1 complex (ASCC) containing the ASCC3 helicase disassembles the leading ribosome in an ATP-dependent reaction. Disassembly, but not ribosome association, requires 40S ubiquitination by ZNF598, but not GTP-dependent factors, including the Pelo-Hbs1L …
The widely conserved ASC-1 complex (ASCC) containing the ASCC3 helicase disassembles the leading ribosome in an ATP-dependent reactio …
The Ski2 helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses.
Cui S, Batenburg NL, Coulombe Y, Arumugam A, Walker JR, Sheida SV, Bielinsky AK, Wahl MC, Masson JY, Zhu XD. Cui S, et al. bioRxiv [Preprint]. 2025 Jul 26:2025.07.24.666583. doi: 10.1101/2025.07.24.666583. bioRxiv. 2025. PMID: 40777259 Free PMC article. Preprint.
ASCC3 has been implicated in transcriptional regulation, alkylation damage repair, and ribosome quality control. ...We demonstrate that ASCC3 also interacts with RPA and stimulates RPA accumulation on ssDNA upon replication stress, promoting ATR activation. ...
ASCC3 has been implicated in transcriptional regulation, alkylation damage repair, and ribosome quality control. ...We demonstrate th …
ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA.
Wollen KL, Hagen L, Vågbø CB, Rabe R, Iveland TS, Aas PA, Sharma A, Sporsheim B, Erlandsen HO, Palibrk V, Bjørås M, Fonseca DM, Mosammaparast N, Slupphaug G. Wollen KL, et al. J Transl Med. 2021 Jul 3;19(1):287. doi: 10.1186/s12967-021-02948-6. J Transl Med. 2021. PMID: 34217309 Free PMC article.
We find that ASCC3-deficient cells display delayed removal of MMS-induced 1-methyladenosine (m(1)A) and 3-methylcytosine (m(3)C) from mRNA and impaired formation of MMS-induced P-bodies. CONCLUSIONS: Our findings conform to a model in which ASCC3-mediated disassembl …
We find that ASCC3-deficient cells display delayed removal of MMS-induced 1-methyladenosine (m(1)A) and 3-methylcytosine (m(3)C) from …
Discovery of a neuromuscular syndrome caused by biallelic variants in ASCC3.
Nair D, Li D, Erdogan H, Yoon A, Harr MH, Bergant G, Peterlin B, Škrjanec Pušenjak M, Jayakar P, Pfundt R, Jansen S, McWalter K, Sidhu A, Saliganan S, Agolini E, Jacob A, Pasquier J, Arash R, Kahrizi K, Najmabadi H, Ropers HH, Bhoj EJ. Nair D, et al. HGG Adv. 2021 Jan 21;2(2):100024. doi: 10.1016/j.xhgg.2021.100024. eCollection 2021 Apr 8. HGG Adv. 2021. PMID: 35047834 Free PMC article.
ASCC3 encodes a DNA helicase responsible for generating single-stranded DNA as part of the DNA damage response. ...In summary we report a syndrome in these eleven individuals from seven families with biallelic variants in ASCC3....
ASCC3 encodes a DNA helicase responsible for generating single-stranded DNA as part of the DNA damage response. ...In summary we repo …
The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations.
Jia J, Absmeier E, Holton N, Pietrzyk-Brzezinska AJ, Hackert P, Bohnsack KE, Bohnsack MT, Wahl MC. Jia J, et al. Nat Commun. 2020 Nov 2;11(1):5535. doi: 10.1038/s41467-020-19221-x. Nat Commun. 2020. PMID: 33139697 Free PMC article.
Other ASCC components integrate ASCC3/AlkBH3 into a complex DNA repair pathway. We mapped and structurally analyzed interacting ASCC2 and ASCC3 regions. ...We quantified contributions of protein regions to the ASCC2-ASCC3 interaction, observing that changes f …
Other ASCC components integrate ASCC3/AlkBH3 into a complex DNA repair pathway. We mapped and structurally analyzed interacting ASCC2 …
CRISPR activation of the ribosome-associated quality control factor ASCC3 ameliorates fragile X syndrome phenotypes in mice.
Geng J, Wang X, Pan J, Khan D, Pimcharoen S, Zhang Y, Mosammaparast N, Hirose S, Petrucelli L, Brandman O, Qi LS, Lu B. Geng J, et al. Sci Transl Med. 2025 Oct 8;17(819):eadq3551. doi: 10.1126/scitranslmed.adq3551. Epub 2025 Oct 8. Sci Transl Med. 2025. PMID: 41061044
Disease-associated ASCC3 variants that perturbed ASCC3-FMRP interaction were also found to be defective in ribosome association and handling of collided ribosomes. In cells of a patient with FXS and the Fmr1 KO mouse model, ASCC3 abundance was reduced, and ov …
Disease-associated ASCC3 variants that perturbed ASCC3-FMRP interaction were also found to be defective in ribosome associatio …
Correlations between ASCC3 Gene Polymorphisms and Chronic Hepatitis B in a Chinese Han Population.
Liu L, Zhang J, Lu Y, Fang C, Li S, Lin J. Liu L, et al. PLoS One. 2015 Nov 4;10(11):e0141861. doi: 10.1371/journal.pone.0141861. eCollection 2015. PLoS One. 2015. PMID: 26536629 Free PMC article.
A significant correlation was observed at SNP rs10485138 located in ASCC3 gene in female patients (OR, 0.445; 95% CI, 0.253-0.784; P = 0.005). Females bearing C allele infected by HBV had an increased susceptibility to CHB compared with those T allele carriers. Our results …
A significant correlation was observed at SNP rs10485138 located in ASCC3 gene in female patients (OR, 0.445; 95% CI, 0.253-0.784; P …
49 results