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Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy.
Dubinsky AN, Dastidar SG, Hsu CL, Zahra R, Djakovic SN, Duarte S, Esau CC, Spencer B, Ashe TD, Fischer KM, MacKenna DA, Sopher BL, Masliah E, Gaasterland T, Chau BN, Pereira de Almeida L, Morrison BE, La Spada AR. Dubinsky AN, et al. Among authors: ashe td. Cell Metab. 2014 Oct 7;20(4):626-38. doi: 10.1016/j.cmet.2014.09.001. Cell Metab. 2014. PMID: 25295787 Free PMC article.