Astles PC[au] - Search Results

Year	Number of Results
1996	1
1998	2
2000	1
2001	1
2002	1
2005	1
2006	1
2007	1
2008	1
2012	1
2013	1
2014	2
2024	2

1

Discovery of a Series of Orally Bioavailable Androgen Receptor Degraders for the Treatment of Prostate Cancer.

Bagal SK, Astles PC, Diène C, Argyrou A, Crafter C, Cassar DJ, Fallan C, Hock A, Jones T, Moreau K, Lamont GM, Lamont S, Michaloglou C, Packer MJ, Pike A, Ramos-Montoya A, Scott JS, Shaw J, Shologu Z. Bagal SK, et al. Among authors: astles pc. J Med Chem. 2024 Jul 25;67(14):11732-11750. doi: 10.1021/acs.jmedchem.4c00269. Epub 2024 Jul 11. J Med Chem. 2024. PMID: 38991141

2

Recent progress in the development of subtype selective nicotinic acetylcholine receptor ligands.

Astles PC, Baker SR, Boot JR, Broad LM, Dell CP, Keenan M. Astles PC, et al. Curr Drug Targets CNS Neurol Disord. 2002 Aug;1(4):337-48. doi: 10.2174/1568007023339256. Curr Drug Targets CNS Neurol Disord. 2002. PMID: 12769608 Review.

3

Identification of Novel Potent NSD2-PWWP1 Ligands Using Structure-Based Design and Computational Approaches.

Carlino L, Astles PC, Ackroyd B, Ahmed A, Chan C, Collie GW, Dale IL, O'Donovan DH, Fawcett C, di Fruscia P, Gohlke A, Guo X, Hao-Ru Hsu J, Kaplan B, Milbradt AG, Northall S, Petrović D, Rivers EL, Underwood E, Webb A. Carlino L, et al. Among authors: astles pc. J Med Chem. 2024 Jun 13;67(11):8962-8987. doi: 10.1021/acs.jmedchem.4c00215. Epub 2024 May 15. J Med Chem. 2024. PMID: 38748070

4

Unique pharmacology of heteromeric α7β2 nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes.

Zwart R, Strotton M, Ching J, Astles PC, Sher E. Zwart R, et al. Among authors: astles pc. Eur J Pharmacol. 2014 Mar 5;726:77-86. doi: 10.1016/j.ejphar.2014.01.031. Eur J Pharmacol. 2014. PMID: 24485886

5

The SAR development of substituted purine derivatives as selective CB2 agonists for the treatment of chronic pain.

Guidetti R, Astles PC, Sanderson AJ, Hollinshead SP, Johnson MP, Chambers MG. Guidetti R, et al. Among authors: astles pc. Bioorg Med Chem Lett. 2014 Dec 15;24(24):5572-5575. doi: 10.1016/j.bmcl.2014.11.006. Epub 2014 Nov 7. Bioorg Med Chem Lett. 2014. PMID: 25466177

6

Selective cannabinoid receptor type 2 (CB2) agonists: optimization of a series of purines leading to the identification of a clinical candidate for the treatment of osteoarthritic pain.

Hollinshead SP, Tidwell MW, Palmer J, Guidetti R, Sanderson A, Johnson MP, Chambers MG, Oskins J, Stratford R, Astles PC. Hollinshead SP, et al. Among authors: astles pc. J Med Chem. 2013 Jul 25;56(14):5722-33. doi: 10.1021/jm400305d. Epub 2013 Jul 3. J Med Chem. 2013. PMID: 23795771

7

Discovery and optimization of novel purines as potent and selective CB2 agonists.

Hollinshead SP, Astles PC, Chambers MG, Johnson MP, Palmer J, Tidwell MW. Hollinshead SP, et al. Among authors: astles pc. Bioorg Med Chem Lett. 2012 Aug 1;22(15):4962-6. doi: 10.1016/j.bmcl.2012.06.035. Epub 2012 Jun 16. Bioorg Med Chem Lett. 2012. PMID: 22765893

8

A practical synthesis of (+/-)-alpha-isosparteine from a tetraoxobispidine core.

Blakemore PR, Kilner C, Norcross NR, Astles PC. Blakemore PR, et al. Among authors: astles pc. Org Lett. 2005 Oct 13;7(21):4721-4. doi: 10.1021/ol0519184. Org Lett. 2005. PMID: 16209519

9

Species selectivity of a nicotinic acetylcholine receptor agonist is conferred by two adjacent extracellular beta4 amino acids that are implicated in the coupling of binding to channel gating.

Young GT, Broad LM, Zwart R, Astles PC, Bodkin M, Sher E, Millar NS. Young GT, et al. Among authors: astles pc. Mol Pharmacol. 2007 Feb;71(2):389-97. doi: 10.1124/mol.106.030809. Epub 2006 Oct 25. Mol Pharmacol. 2007. PMID: 17065235

10

Total synthesis of (+/-)-alpha-isosparteine, (+/-)-beta-isosparteine, and (+/-)-sparteine from a common tetraoxobispidine intermediate.

Norcross NR, Melbardis JP, Solera MF, Sephton MA, Kilner C, Zakharov LN, Astles PC, Warriner SL, Blakemore PR. Norcross NR, et al. Among authors: astles pc. J Org Chem. 2008 Oct 17;73(20):7939-51. doi: 10.1021/jo8013512. Epub 2008 Sep 18. J Org Chem. 2008. PMID: 18798673

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