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68 results

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Page 1
ATP10A deficiency results in male-specific infertility in mice.
Norris AC, Yazlovitskaya EM, Yang TS, Mansueto A, Stafford JM, Graham TR. Norris AC, et al. Front Cell Dev Biol. 2024 Feb 13;12:1310593. doi: 10.3389/fcell.2024.1310593. eCollection 2024. Front Cell Dev Biol. 2024. PMID: 38415274 Free PMC article.
Therefore, we tested the influence of ATP10A on reproduction by examining fertility of Atp10A knockout mice. Our findings reveal that Atp10A deficiency leads to male-specific infertility, but does not perturb fertility in the females. The Atp10A defici …
Therefore, we tested the influence of ATP10A on reproduction by examining fertility of Atp10A knockout mice. Our findings reve …
Single-nucleus multiregion transcriptomic analysis of brain vasculature in Alzheimer's disease.
Sun N, Akay LA, Murdock MH, Park Y, Galiana-Melendez F, Bubnys A, Galani K, Mathys H, Jiang X, Ng AP, Bennett DA, Tsai LH, Kellis M. Sun N, et al. Nat Neurosci. 2023 Jun;26(6):970-982. doi: 10.1038/s41593-023-01334-3. Epub 2023 Jun 1. Nat Neurosci. 2023. PMID: 37264161 Free PMC article.
We identify 2,676 differentially expressed genes in AD, including downregulation of PDGFRB in pericytes, and of ABCB1 and ATP10A in endothelial cells, and validate the downregulation of SLC6A1 and upregulation of APOD, INSR and COL4A1 in postmortem AD brain tissues. ...
We identify 2,676 differentially expressed genes in AD, including downregulation of PDGFRB in pericytes, and of ABCB1 and ATP10A in e …
Deficiency of the lipid flippase ATP10A causes diet-induced dyslipidemia in female mice.
Norris AC, Yazlovitskaya EM, Zhu L, Rose BS, May JC, Gibson-Corley KN, McLean JA, Stafford JM, Graham TR. Norris AC, et al. bioRxiv [Preprint]. 2023 Aug 14:2023.06.16.545392. doi: 10.1101/2023.06.16.545392. bioRxiv. 2023. Update in: Sci Rep. 2024 Jan 3;14(1):343. doi: 10.1038/s41598-023-50360-5. PMID: 37398141 Free PMC article. Updated. Preprint.
However, the influence of ATP10A on lipid metabolism in mice has not been explored. Here, we generated gene-specific Atp10A knockout mice and show that Atp10A(-/-) mice fed a high-fat diet did not gain excess weight relative to wild-type littermates. ...Thus, …
However, the influence of ATP10A on lipid metabolism in mice has not been explored. Here, we generated gene-specific Atp10A kn …
Deficiency of the lipid flippase ATP10A causes diet-induced dyslipidemia in female mice.
Norris AC, Yazlovitskaya EM, Zhu L, Rose BS, May JC, Gibson-Corley KN, McLean JA, Stafford JM, Graham TR. Norris AC, et al. Sci Rep. 2024 Jan 3;14(1):343. doi: 10.1038/s41598-023-50360-5. Sci Rep. 2024. PMID: 38172157 Free PMC article.
However, the influence of ATP10A on lipid metabolism in mice has not been explored. Here, we generated gene-specific Atp10A knockout mice and show that Atp10A(-/-) mice fed a high-fat diet did not gain excess weight relative to wild-type littermates. ...Thus, …
However, the influence of ATP10A on lipid metabolism in mice has not been explored. Here, we generated gene-specific Atp10A kn …
Phospholipid Flippase ATP10A Translocates Phosphatidylcholine and Is Involved in Plasma Membrane Dynamics.
Naito T, Takatsu H, Miyano R, Takada N, Nakayama K, Shin HW. Naito T, et al. J Biol Chem. 2015 Jun 12;290(24):15004-17. doi: 10.1074/jbc.M115.655191. Epub 2015 May 6. J Biol Chem. 2015. PMID: 25947375 Free PMC article.
Importantly, expression of ATP10A, but not ATP10A(E203Q), dramatically altered the cell shape and decreased cell size. In addition, expression of ATP10A, but not ATP10A(E203Q), delayed cell adhesion and cell spreading onto the extracellular matrix. ...
Importantly, expression of ATP10A, but not ATP10A(E203Q), dramatically altered the cell shape and decreased cell size. In addi …
Atp10a, a gene adjacent to the PWS/AS gene cluster, is not imprinted in mouse and is insensitive to the PWS-IC.
DuBose AJ, Johnstone KA, Smith EY, Hallett RA, Resnick JL. DuBose AJ, et al. Neurogenetics. 2010 May;11(2):145-51. doi: 10.1007/s10048-009-0226-9. Epub 2009 Nov 6. Neurogenetics. 2010. PMID: 19894069
We report that Atp10a is biallelically expressed in both the newborn and adult brain, and Atp10a allelic expression is insensitive to deletion or mutation of the PWS imprinting center. The CpG island associated with Atp10a is hypomethylated, a result consiste …
We report that Atp10a is biallelically expressed in both the newborn and adult brain, and Atp10a allelic expression is insensi …
A novel circRNA-miRNA-mRNA network revealed exosomal circ-ATP10A as a biomarker for multiple myeloma angiogenesis.
Yu M, Yu J, Zhang Y, Sun X, Sun R, Xia M, Li S, Cui X. Yu M, et al. Bioengineered. 2022 Jan;13(1):667-683. doi: 10.1080/21655979.2021.2012553. Bioengineered. 2022. PMID: 34852710 Free PMC article.
We screened 2,052 circRNAs with significant differential expression between MM patients and healthy controls via high-throughput sequencing. qRT-PCR confirmed that the expression of circ-ATP10A was significantly increased in MM patients. The bioinformatics analyses suggest …
We screened 2,052 circRNAs with significant differential expression between MM patients and healthy controls via high-throughput sequencing. …
Atp10a, the mouse ortholog of the human imprinted ATP10A gene, escapes genomic imprinting.
Kayashima T, Yamasaki K, Joh K, Yamada T, Ohta T, Yoshiura K, Matsumoto N, Nakane Y, Mukai T, Niikawa N, Kishino T. Kayashima T, et al. Genomics. 2003 Jun;81(6):644-7. doi: 10.1016/s0888-7543(03)00077-6. Genomics. 2003. PMID: 12782135
The mouse Atp10a gene is located at the border of an imprinted domain distal to the p-locus on mouse chromosome 7. ...These findings suggest that the mouse Atp10a gene escapes genomic imprinting....
The mouse Atp10a gene is located at the border of an imprinted domain distal to the p-locus on mouse chromosome 7. ...These findings …
Gender influences monoallelic expression of ATP10A in human brain.
Hogart A, Patzel KA, LaSalle JM. Hogart A, et al. Hum Genet. 2008 Oct;124(3):235-42. doi: 10.1007/s00439-008-0546-0. Epub 2008 Aug 23. Hum Genet. 2008. PMID: 18726118 Free PMC article.
The mechanisms involved in parental imprinting of this locus are conserved between human and mouse, yet inconsistencies exist in reports of imprinting of the maternally expressed gene Atp10a/ATP10A. Excess maternal 15q11-13 dosage often leads to autism-spectrum diso …
The mechanisms involved in parental imprinting of this locus are conserved between human and mouse, yet inconsistencies exist in reports of …
Novel phosphatidylinositol flippases contribute to phosphoinositide homeostasis in the plasma membrane.
Muranaka Y, Shigetomi R, Iwasaki Y, Hamamoto A, Nakayama K, Takatsu H, Shin HW. Muranaka Y, et al. Biochem J. 2024 Sep 18;481(18):1187-1202. doi: 10.1042/BCJ20240223. Biochem J. 2024. PMID: 39258799
Here, we discovered that the phosphatidylcholine flippases ATP8B1, ATP8B2, and ATP10A can also translocate phosphatidylinositol at the plasma membrane. To explore the function of these phosphatidylinositol flippases, we used cells depleted of CDC50A, a protein necessary fo …
Here, we discovered that the phosphatidylcholine flippases ATP8B1, ATP8B2, and ATP10A can also translocate phosphatidylinositol at th …
68 results