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ATP4A autoimmunity in pediatric patients with type 1 diabetes and its relationship to blood count, iron metabolism, and vitamin B12.
Chobot A, Rusak E, Wenzlau J, Davidson H, Adamczyk P, Krzywicka A, Mazur B, Polańska J, Rewers M. Chobot A, et al. Pediatr Diabetes. 2018 Feb;19(1):80-84. doi: 10.1111/pedi.12528. Epub 2017 Apr 12. Pediatr Diabetes. 2018. PMID: 28401620
RESULTS: A total of 16 (17%) children were ATP4A positive. Serum concentrations of ferritin were significantly lower in ATP4A positive than in antibody negative subjects (P = .034). ...In ATP4A positive patients, the ATP4A Index correlated positively w …
RESULTS: A total of 16 (17%) children were ATP4A positive. Serum concentrations of ferritin were significantly lower in ATP4A …
Autoantibodies against ATP4A are a feature of the abundant autoimmunity that develops in first-degree relatives of patients with type 1 diabetes.
Zielmann ML, Jolink M, Winkler C, Eugster A, Müller D, Scholz M, Ziegler AG, Bonifacio E. Zielmann ML, et al. Pediatr Diabetes. 2022 Sep;23(6):714-720. doi: 10.1111/pedi.13361. Epub 2022 May 22. Pediatr Diabetes. 2022. PMID: 35561070
METHODS: Autoantibodies to the parietal cell autoantigen, H(+) /K(+) ATPase subunit A (ATP4A) was measured in 2218 first-degree relatives of patients with type 1 diabetes, who were prospectively followed from birth for a median of 14.5 years. ...RESULTS: The cumulative ris …
METHODS: Autoantibodies to the parietal cell autoantigen, H(+) /K(+) ATPase subunit A (ATP4A) was measured in 2218 first-degree relat …
Reactivation of Atp4a concomitant with intragenic DNA demethylation for cancer inhibition in a gastric cancer model.
Cao D, Zhao D, Jia Z, Su T, Zhang Y, Wu Y, Wu M, Tsukamoto T, Oshima M, Jiang J, Cao X. Cao D, et al. Life Sci. 2020 Feb 1;242:117214. doi: 10.1016/j.lfs.2019.117214. Epub 2019 Dec 26. Life Sci. 2020. PMID: 31884095
In addition, CpG island (CGI) search showed that the CpG rich region is absent in the promoter region but present in exons 9-14 of Atp4a. Methylation specific PCR (MSP) indicated that Atp4a was fully or partly methylated in multiple GC cells. Further MassArray sugge …
In addition, CpG island (CGI) search showed that the CpG rich region is absent in the promoter region but present in exons 9-14 of Atp4a …
ESRRG, ATP4A, and ATP4B as Diagnostic Biomarkers for Gastric Cancer: A Bioinformatic Analysis Based on Machine Learning.
Chen Q, Wang Y, Liu Y, Xi B. Chen Q, et al. Front Physiol. 2022 Jun 23;13:905523. doi: 10.3389/fphys.2022.905523. eCollection 2022. Front Physiol. 2022. PMID: 35812327 Free PMC article.
The NCBI Gene Expression Omnibus (GEO) database was used to obtain gene expression files. Three hub genes (ESRRG, ATP4A, and ATP4B) were detected through a combination of weighted gene co-expression network analysis (WGCNA), gene-gene interaction network analysis, and supe …
The NCBI Gene Expression Omnibus (GEO) database was used to obtain gene expression files. Three hub genes (ESRRG, ATP4A, and ATP4B) w …
ATP4a is required for Wnt-dependent Foxj1 expression and leftward flow in Xenopus left-right development.
Walentek P, Beyer T, Thumberger T, Schweickert A, Blum M. Walentek P, et al. Cell Rep. 2012 May 31;1(5):516-27. doi: 10.1016/j.celrep.2012.03.005. Epub 2012 Apr 20. Cell Rep. 2012. PMID: 22832275 Free article.
In the frog Xenopus asymmetric expression of the ion pump ATP4a was reported at the 4-cell stage. The "ion-flux" model postulates that symmetry is broken flow-independently through an ATP4-generated asymmetric voltage gradient that drives serotonin through gap junctions to …
In the frog Xenopus asymmetric expression of the ion pump ATP4a was reported at the 4-cell stage. The "ion-flux" model postulates tha …
Weipiling ameliorates gastric precancerous lesions in Atp4a(-/-) mice.
Liu W, Zhao ZM, Liu YL, Pan HF, Lin LZ. Liu W, et al. BMC Complement Altern Med. 2019 Nov 19;19(1):318. doi: 10.1186/s12906-019-2718-y. BMC Complement Altern Med. 2019. Retraction in: BMC Complement Med Ther. 2023 Apr 1;23(1):98. doi: 10.1186/s12906-023-03941-w. PMID: 31744486 Free PMC article. Retracted.
METHODS: Firstly, the major components of WPL are chemically characterized by HPLC analytical method. In this study, we chose the Atp4a(-/-) mouse model (Spicer etal., J Biol Chem 275:21555-21565, 2000) for GPL analysis. ...CONCLUSIONS: Conclusively, WPL could ameliorate G …
METHODS: Firstly, the major components of WPL are chemically characterized by HPLC analytical method. In this study, we chose the Atp4a …
Autoantibodies Toward ATP4A and ATP4B Subunits of Gastric Proton Pump H+,K+-ATPase Are Reliable Serological Pre-endoscopic Markers of Corpus Atrophic Gastritis.
Lahner E, Marzinotto I, Lampasona V, Dottori L, Bazzigaluppi E, Brigatti C, Secchi M, Piemonti L, Conti L, Pilozzi E, Davidson HW, Wenzlau JM, Annibale B. Lahner E, et al. Clin Transl Gastroenterol. 2020 Oct;11(10):e00240. doi: 10.14309/ctg.0000000000000240. Clin Transl Gastroenterol. 2020. PMID: 33031196 Free PMC article.
Autoantibodies against the individual alpha (ATP4A) and beta (ATP4B) subunits of ATP4 were measured by luciferase immunoprecipitation, and global PCA and pepsinogen I by enzyme-linked immunosorbent assay. ...ATP4B, ATP4A, and pepsinogen I tests showed sensitivities …
Autoantibodies against the individual alpha (ATP4A) and beta (ATP4B) subunits of ATP4 were measured by luciferase immunoprecipitation …
ATP4A autoimmunity and Helicobacter pylori infection in children with type 1 diabetes.
Chobot A, Wenzlau J, Bak-Drabik K, Kwiecien J, Polanska J, Rewers M. Chobot A, et al. Clin Exp Immunol. 2014 Sep;177(3):598-602. doi: 10.1111/cei.12363. Clin Exp Immunol. 2014. PMID: 24773566 Free PMC article.
Persistent presence of ATP4A autoantibodies (ATP4AA) directed towards parietal cells is typical for atrophic body gastritis (ABG), an autoimmune disease associated with type 1 diabetes. ...ATP4AA were more prevalent in females [42% (26-58%)] than males [16% (3-28%)], P = 0 …
Persistent presence of ATP4A autoantibodies (ATP4AA) directed towards parietal cells is typical for atrophic body gastritis (ABG), an …
Differential expression of KCNQ1 and ATP4A genes according to the sex and age in the stomach.
Haddadi A, Farhadi P, Fatemi R, Mohamadynejad P, Moghanibashi M. Haddadi A, et al. Nucleosides Nucleotides Nucleic Acids. 2023;42(12):1019-1027. doi: 10.1080/15257770.2023.2228371. Epub 2023 Jun 27. Nucleosides Nucleotides Nucleic Acids. 2023. PMID: 37367232
In addition, the expression level of the ATP4A gene in men under 35 years was significantly higher than in men above 50 (p = 0.026). ...
In addition, the expression level of the ATP4A gene in men under 35 years was significantly higher than in men above 50 (p = 0.026). …
100 results