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936 results

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Page 1
ATXN3: a multifunctional protein involved in the polyglutamine disease spinocerebellar ataxia type 3.
Hernández-Carralero E, Quinet G, Freire R. Hernández-Carralero E, et al. Expert Rev Mol Med. 2024 Sep 25;26:e19. doi: 10.1017/erm.2024.10. Expert Rev Mol Med. 2024. PMID: 39320846 Free PMC article. Review.
ATXN3 is a ubiquitin hydrolase (or deubiquitinase, DUB), product of the ATXN3 gene, ubiquitously expressed in various cell types including peripheral and neuronal tissues and involved in several cellular pathways. ...The mentioned molecular functions of ATXN3 …
ATXN3 is a ubiquitin hydrolase (or deubiquitinase, DUB), product of the ATXN3 gene, ubiquitously expressed in various cell typ …
CRISPR screening identifies the deubiquitylase ATXN3 as a PD-L1-positive regulator for tumor immune evasion.
Wang S, Iyer R, Han X, Wei J, Li N, Cheng Y, Zhou Y, Gao Q, Zhang L, Yan M, Sun Z, Fang D. Wang S, et al. J Clin Invest. 2023 Dec 1;133(23):e167728. doi: 10.1172/JCI167728. J Clin Invest. 2023. PMID: 38038129 Free PMC article.
Herein, we describe a CRISPR-based screening platform and identified ATXN3 as a positive regulator for PD-L1 transcription. TCGA database analysis revealed a positive correlation between ATXN3 and CD274 in more than 80% of human cancers. ...Collectively, our study i …
Herein, we describe a CRISPR-based screening platform and identified ATXN3 as a positive regulator for PD-L1 transcription. TCGA data …
ATXN3 functions as a tumor suppressor through potentiating galectin-9-mediated apoptosis in human colon adenocarcinoma.
Cheng Y, Wang S, Gao Q, Fang D. Cheng Y, et al. J Biol Chem. 2024 Jul;300(7):107415. doi: 10.1016/j.jbc.2024.107415. Epub 2024 May 28. J Biol Chem. 2024. PMID: 38815863 Free PMC article.
CRISPR-mediated ATXN3 deletion unexpectedly intensified colon cancer growth both in vitro and in xenograft colon cancers. At the molecular level, we identified ATXN3 as a bona fide deubiquitinase specifically targeting Galectin-9, as ATXN3 interacted with and …
CRISPR-mediated ATXN3 deletion unexpectedly intensified colon cancer growth both in vitro and in xenograft colon cancers. At the mole …
ATXN3 regulates lysosome regeneration after damage by targeting K48-K63-branched ubiquitin chains.
Reinders M, Kravic B, Gahlot P, Koska S, van den Boom J, Schulze N, Levantovsky S, Kleine S, Kaiser M, Kulathu Y, Behrends C, Meyer H. Reinders M, et al. EMBO J. 2025 Sep;44(18):5086-5111. doi: 10.1038/s44318-025-00517-x. Epub 2025 Jul 29. EMBO J. 2025. PMID: 40730717 Free PMC article.
We find that ATXN3 is required for lysophagic flux after lysosomal damage but is not involved in the initial phagophore formation on terminally damaged lysosomes. ...There, ATXN3, along with its partner VCP/p97, targets and turns over K48-K63-branched ubiquitin conj …
We find that ATXN3 is required for lysophagic flux after lysosomal damage but is not involved in the initial phagophore formation on …
ATXN3 controls DNA replication and transcription by regulating chromatin structure.
Hernández-Carralero E, Cabrera E, Rodríguez-Torres G, Hernández-Reyes Y, Singh AN, Santa-María C, Fernández-Justel JM, Janssens RC, Marteijn JA, Evert BO, Mailand N, Gómez M, Ramadan K, Smits VAJ, Freire R. Hernández-Carralero E, et al. Nucleic Acids Res. 2023 Jun 23;51(11):5396-5413. doi: 10.1093/nar/gkad212. Nucleic Acids Res. 2023. PMID: 36971114 Free PMC article.
ATXN3 has multiple functions, such as regulating transcription or controlling genomic stability after DNA damage. ...The absence of ATXN3 decreases the recruitment of endogenous HDAC3 to the chromatin, as well as the HDAC3 nuclear/cytoplasm ratio after HDAC3 overexp …
ATXN3 has multiple functions, such as regulating transcription or controlling genomic stability after DNA damage. ...The absence of …
ATXN3 promotes prostate cancer progression by stabilizing YAP.
Wu L, Ou Z, Liu P, Zhao C, Tong S, Wang R, Li Y, Yuan J, Chen M, Fan B, Zu X, Wang Y, Tang J. Wu L, et al. Cell Commun Signal. 2023 Jun 22;21(1):152. doi: 10.1186/s12964-023-01073-9. Cell Commun Signal. 2023. PMID: 37349820 Free PMC article.
Further mechanistic study revealed that the Josephin domain of ATXN3 interacted with the WW domain of YAP. ATXN3 stabilized YAP protein via inhibiting K48-specific poly-ubiquitination process on YAP protein. In addition, ATXN3 depletion significantly decrease …
Further mechanistic study revealed that the Josephin domain of ATXN3 interacted with the WW domain of YAP. ATXN3 stabilized YA …
ATXN3 deubiquitinates ZEB1 and facilitates epithelial-mesenchymal transition in glioblastoma.
Wei R, Shi X, Qiu W, Yang M, Chen Y, Song S, Yang H, Liu J. Wei R, et al. Sci Rep. 2025 Mar 6;15(1):7868. doi: 10.1038/s41598-025-92317-w. Sci Rep. 2025. PMID: 40050358 Free PMC article.
In this study, we found that GBM tissues and cells exhibit significantly elevated expression levels of ataxin 3 (ATXN3). Functional experiments demonstrated that ATXN3 promotes the invasion, migration, and tumor growth of GBM cells by activating EMT. ...ATXN3 …
In this study, we found that GBM tissues and cells exhibit significantly elevated expression levels of ataxin 3 (ATXN3). Functional e …
ATXN3 promotes breast cancer metastasis by deubiquitinating KLF4.
Zou H, Chen H, Zhou Z, Wan Y, Liu Z. Zou H, et al. Cancer Lett. 2019 Dec 28;467:19-28. doi: 10.1016/j.canlet.2019.09.012. Epub 2019 Sep 26. Cancer Lett. 2019. PMID: 31563563
High ATXN3/KLF4 expression was associated with a poor prognosis in breast cancer patients. Collectively, we identified ATXN3 as a novel deubiquitinating enzyme of KLF4, providing a new explanation for breast cancer metastasis, and proposed ATXN3 as a potentia …
High ATXN3/KLF4 expression was associated with a poor prognosis in breast cancer patients. Collectively, we identified ATXN3 a …
ATXN3 promotes proliferation, stemness and motility of clear cell renal cell carcinoma cells by regulating S100A8 ubiquitination.
Bai J, Han J, Fan J, Song J, Wang S. Bai J, et al. Physiol Int. 2023 Nov 8;110(4):311-325. doi: 10.1556/2060.2023.00247. Print 2023 Dec 18. Physiol Int. 2023. PMID: 37938238
The binding between ATXN3 and S100A8 and the effect of ATXN3 on S100A8 ubiquitination were verified using coimmunoprecipitation. ...ATXN3 enhanced the activity of the NF-kappaB pathway. Silencing ATXN3 facilitated S100A8 ubiquitination. ...
The binding between ATXN3 and S100A8 and the effect of ATXN3 on S100A8 ubiquitination were verified using coimmunoprecipitatio …
936 results